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Biomedical subjects

J C Raeder

Publications and source records attributed to J C Raeder.

56 records · Page 4Linked to original sources

Tracheal tube cuff pressures. The effects of different gas mixtures.

Changes in cuff pressure and volume of tracheal tubes were studied in 60 patients undergoing lower abdominal surgery under general anaesthesia with nitrous oxide and oxygen as the anaesthetic gas mixture. The cuffs were inflated with either anaesthetic gas mixture or air. Three different brands of tubes were used. The pressure in the air filled cuffs increased steadily throughout the procedure and reached level high enough to impede microcirculation in the tracheal mucosa within one hour. We conclude that filling the cuff with anaesthetic gas mixture is a simple and reliable way to achieve stable cuff pressure during anaesthesia.

Air↗

Anaphylactoid reaction caused by intravenous doxycycline during general anesthesia and beta-blockade treatment.

A 71-year-old woman with icterus was treated with doxycycline orally for one week. She then was admitted for an exploratory laparotomy under general anesthesia with barbiturate, pancuronium, fentanyl, and nitrous oxide. She developed rapid atrial fibrillation and received digitoxin and beta-blockade. Thirty minutes after her last medication she received doxycycline 100 mg in 200 ml sodium chloride 0.9% infused over five to ten minutes. Soon after the completed infusion, she developed a severe anaphylactoid reaction with bronchospasm, hypotension, and generalized urticaria, which was treated successfully with ephedrine, aminophylline, hydrocortisone, furosemide, metaraminol, ketamine, and epinephrine. The possibility of beta-blockade treatment worsening the reaction is discussed and five other reports of anaphylactoid reactions to intravenous doxycycline are mentioned.

Adrenergic beta-Antagonists↗