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J C Patel

Publications and source records attributed to J C Patel.

At least 55 records · Page 3Linked to original sources
PubMed1997

Peptide substrates suitable for assaying glycogen synthase kinase-3 in crude cell extracts.

In this study we describe the characterization and use of new peptide substrates for assaying glycogen synthase kinase-3 (GSK-3) which are based on the sequence around the single GSK-3 phosphorylation site in the translation factor eIF2B. The new peptides offer important advantages over previous substrates, which were based on the sequence around the multiple GSK-3 phosphorylation sites in glycogen synthase (GS), for the assay of GSK-3 in cell extracts. In particular, decreases in GSK-3 activity following, e.g., insulin treatment, are partially or completely masked when the GS-based peptides are used but are readily measured using the new, eIF2B-based, peptides. The new peptides, unlike those based on GS, are therefore suitable for the assay of changes in GSK-3 activity in cell extracts without the need for prior immunoprecipitation or ion-exchange chromatography.

3T3 Cells↗
PubMed1997

[Gallstone ileus: plea for simultaneous treatment of obstruction and gallstone disease].

All patients with gallstone ileus admitted to our institution between 1985 and 1995, were retrospectively analysed, to determine, whether a one stage procedure (removal of impacted gallstone, fistula repair and cholecystectomy) is a more valid option than enterotomy. There were 10 patients (8 women, 2 men) in the study group (age range: 63-86 ans), representing 3.7% of small bowel obstruction and 1.4% of patients who underwent biliary surgery during the same period. Bowel occlusion was present in 8 patients and a correct preoperative diagnosis was made in only 2 cases (20%). Eight patients had a one-stage procedure, with no mortality but complications occurred in 2 cases. Enterotomy was the only surgical treatment in 2 cases, with no morbidity. During follow-up period, one patient died 3 years after enterotomy from a biliary complication. We believe that a one-step procedure, is a valid option and should be undertaken to prevent future recurrence, later biliary complications and reoperations in these elderly patients, who have serious concomitant diseases.

Aged↗
PubMed1996

[Rupture to the skin of atheromatous aneurysm on a femoropopliteal venous bypass using an in situ vein].

Atheromatous aneurysmal degeneration of a venous bypass graft is a rare and late event after venous bypass grafting. We report the case of a 49-year-old man in whom a large aneurysm of a saphenous graft implanted 10 years earlier ruptured to the skin. Amputation was required. Graft degeneration can lead to complications which may be life or limb-threatening due to graft rupture, graft thrombosis or distal embolization. Close follow-up after arterial reconstruction using a vein graft is therefore highly warranted for early detection and correction of any abnormalities before onset of complications.

Anastomosis, Surgical↗
PubMed1996

[Acute appendicitis in patients over 70 years of age].

OBJECTIVES: We assessed preoperative diagnosis of appendicitis and perforations in elderly patients in our unit to determine whether the overall higher rate of appendectomy in France (3 to 4 times higher than in anglo-saxon countries) has an effect. METHODS: We analyzed retrospectively the cases of all patients over 70 years of age who undervent appendectomy for histologically confirmed appendicitis between February 1, 1990 and 31 January 1995. RESULTS: There were 20 patients (15 women 5 men) in the study group (age range 70-89 years). The site of abdominal pain was atypical in 10 cases (50%) and acute bowel occlusion occurred in 9 (45%). The diagnosis of appendicitis was made before surgery in 10 patients; surgery was performed within 24 hours of admission in only 8. The high rate of perforations (70%) was not correlated with age. Complications occurred in 70% of the cases and were related to perforation (p < 0.02) and an American Society of Anesthesia (ASA) score > 2 (p < 0.05). CONCLUSION: Acute appendicitis in the elderly patient is a serious condition. The atypical nature of the clinical presentation in half of the patients often requires computed tomography or laparoscopy for diagnosis.

Acute Disease↗
PubMed1996

[Yersinia enterocolitica: a cause of acute intestinal intussusception].

OBJECTIVES: Yersinia enterocolitica infection is a rare cause of intestinal intussusception, especially in adults. We report here a case in a 29-year-old man and review the literature on diagnosis and therapy. CASE REPORT: A 29-year-old man presented with a 2-week history of diarrhea and weight loss. Ultrasonography revealed acute intestinal intussusception localized at the site of enlarged mesenteric nodes. At laparostomy, intestinal resection was not required. Histology examination of the mesenteric nodes showed follicular hyperplasia. Serology was positive for Yersinia enterocolitica. Outcome was favorable after treatment with tetracycline for 15 days. DISCUSSION: Yersinia enterocolitica are Gram negative bacilli that grow at low temperature. Food contamination is the most frequent source of infection in man, usually in children. Clinical manifestations include gastroenteritis or pseudoappendicular syndrome. Intestinal intussusception is rare. Operative reduction by taxis is generally sufficient. Histology examination of the lymph nodes excludes lymphoma. The diagnosis is confirmed by serology. A 10 to 15-day antibiotic regimen is needed.

Acute Disease↗
PubMed1995

[Celioscopy in the treatment of acute small bowel occlusions: preliminary results].

OBJECTIVE: The aim of this study was to determine the applicability and short-term results as well as the indications for laparoscopic surgery in acute occlusion of the small bowel. METHODS: From May to September 1995, 9 consecutive patients (8 females, 1 male, mean age 54.4 years, range 27-82), hospitalized for acute occlusion of the small bowel were included in an evaluation of laparoscopic cure. Patients were divided into two groups according to the presence (n = 5) or absence (n = 4) of a past history of medial laparotomy. RESULTS: Laparoscopic surgery was used in all patients with no complications. In the group with a past history of laparotomy, the procedures were more difficult and the duration of the procedure was longer (220 +/- 74 min versus 104 +/- 11) (p < 0.01). The advantages of laparoscopic surgery were decreased post-operative pain and shorter duration of ileus and hospitalization. CONCLUSION: Laparoscopic treatment of acute occlusion of the bowel is possible. The procedure should probably be reserved for patient without a past history of medial laparotomy. A long-term study is required to assess the risk of recurrence.

Acute Disease↗
PubMed1995

[Introducing an implantable central venous catheter via the right pudendal vein].

Implantable central venous catheters are routinely introduced in the subclavian or jugular veins. In some cases such as thrombosis or infection, this localization must be avoided. In these circumstances, the inferior vena cava is used. The catheter can be inserted into the inferior vena cava via the right genital vein. Surgery is performed under general or loco-regional anesthesia. The right genital vein is approached using a MacBurney incision. The retroperitoneum is entered and the right genital vein is cannulated. The catheter tip is placed at the limit between the inferior vena cava and the right atrium. The port is placed in a subcutaneous pocket in the lower part of the thorax. In cases where the right genital vein is too narrow to allow catheterization, it is easy to proceed through the same incision and puncture the inferior vena cava.

Catheterization, Central Venous↗
PubMed1995

[Hydatid cyst of the psoas].

Recurrent hydatic cyst of the psoas is an exceptional disease in France but should not be missed in patients coming from endemic areas. A case report and a review of the literature on the aetiopathology, diagnosis and therapy are presented. Abdominal pelvic CT scan should give the diagnosis. Surgical treatment is indicated, with complete exeresis to avoid early relapse.

Adult↗
PubMed1995

[Mucocele of the appendix: value of excision by celioscopy].

A mucocele of the appendix was complicated by appendicular volvulus. The CT-scan findings suggested the diagnosis which was confirmed at laparoscopy. This case illustrates the contribution of laparoscopy in diagnosis and treatment of mucoceles of the appendix.

Adult↗