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Biomedical subjects

J C Pastor Jimeno

Publications and source records attributed to J C Pastor Jimeno.

At least 19 recordsLinked to original sources

[Corneal epithelial complications after vitrectomy: a retrospective study].

PURPOSE: To establish the incidence, evolution and final visual outcome of corneal epithelial complications after vitrectomy in a consecutive series performed throughout a period of one year. METHODS: 195 consecutive medical records of patients vitrectomized in 2001 have been retrospectively reviewed. Patients were clinically evaluated the day after vitrectomy, during the first week, and then weekly for 3 months (minimum follow-up). Functional results have been established at the end of this period. RESULTS: 12 out of 195 eyes developed corneal epithelial complications after surgery (6.1%). Eight cases were diagnosed of persistent epithelial defect (4.1%), and four cases (2%) of necrotizing herpetic keratitis. Six out of 12 were diabetic. Corneal epithelial complications affected 10.5% of diabetic and 4.3% of non-diabetic patients (p=0.10). The majority of persistent epithelial defects healed without sequelae in less than two months. Herpetic keratitis required between 3 to 4 months to heal and caused corneal scarring in all cases. CONCLUSIONS: Persistent corneal epithelial defects after vitrectomy are a relatively frequent complication, mainly in diabetic patients. Recurrence of herpetic keratitis must also be kept in mind. This finding has not been previously reported and needs further studies.

Corneal Diseases↗

[Experimental study on usefulness of silicone-fluorsilicone copolymer oil (SiFO) in vitreoretinal surgery].

PURPOSE: To evaluate the usefulness of silicone-fluorsilicone copolymer oil (SiFO) as an intraoperative tool and a vitreous substitute in vitreoretinal surgery. METHODS: Handling properties of SiFO were tested and compared with those of perfluorooctane (PFO). The transparency of both substances was measured by spectrophotometry and subjectively assessed. Their tendency to dispersion was observed during injection in balanced saline solution (BSS) and after mechanized and manual shaking. Ease of injection and aspiration through small-gauge instruments was evaluated. Ocular tolerance to SiFO and PFO was studied after intravitreal injection in rabbit eyes: intraocular pressure, anterior segment inflammatory response and dispersion were evaluated, and a histopathological study was performed. RESULTS: Injection and aspiration of SiFO were more difficult than those of PFO because of its higher viscosity. PFO dispersed progressively into small droplets as early as two days after intravitreal injection, whereas SiFO remained as a single bubble for 14 days. Histopathologically both substances induced an inflammatory response over the inferior retina, with microvacuolated macrophages and foreign body giant cells, which were larger in eyes wearing SiFO. CONCLUSIONS: SiFO may be useful as an intraoperative tool, although its main drawback is a more difficult injection and aspiration compared to PFO. It has been well tolerated as a short-term vitreous substitute, but further clinical studies are needed.

Animals↗

[Symptomatic ciliary body melanocytoma: melanocytomalytic glaucoma].

CASE REPORT: A 33 year-old female with an asymptomatic pigmented mass in the iridocorneal angle of her right eye, arising from the ciliary body is presented. Ciliary body melanocytoma was suspected and conservative management recommended. After 36 months of follow-up the patient developed pain, inflammatory reaction and uncontrollable ocular hypertension, which was diagnosed as melanocytomalytic glaucoma. Tumor was removed by external iridecyclectomy and the histopathologic findings revealed necrotic melanocytoma. DISCUSSION: Ciliary body melanocytoma is a rare benign pigmented tumor that may present extension to the anterior chamber. Differential diagnosis mainly includes ciliary body melanoma, which carries a different prognosis and treatment.

Adult↗

[Sympathetic ophthalmia post-vitrectomy following trauma and perfluorocarbon liquid tamponade].

CASE REPORT: We report a case of sympathetic ophthalmia (SO) developed after blunt trauma and vitrectomy (complicated with a massive suprachoroidal hemorrhage) using perfluorocarbon liquid (PFCL) for tamponade. DISCUSSION: The presentation of SO in a vitrectomized patient after severe blunt trauma with extended intra-ocular tamponade with PFCL could support the hypothesis that chronic inflammation caused by PFCL could have contributed to the development of SO. Nevertheless, there are other possible causal factors such as the trauma, the vitrectomy itself or the choroidal detachment with possible uveal incarceration at wound sites.

Aged↗

[Can the use of intraocular silicone oil increase the risk of sympathetic ophthalmia?].

CLINICAL CASES: We report two cases of SO (sympathetic ophthalmia) among 1,456 vitrectomies and 255 silicone oil injections performed since 1990. In both patients intraocular silicone oil was used. Both cases were clinically documented and one pathologically demonstrated. DISCUSSION: No cases were reported among vitrectomies without silicone oil. We found a longer delay between injury and the onset of the disease in comparison to the literature. Pathological findings confirmed a foreign body granulomatous reaction. Chronic inflammation caused by silicone oil might be involved in the development of SO. Larger series are necessary to establish a possible relationship between silicone oil and SO.

Aged↗

[Iatrogenic retinal breaks during vitrectomy: retrospective study].

PURPOSE: To establish the incidence and characteristics of iatrogenic retinal breaks occurring during vitrectomy and to propose a protocol for their management. METHODS: Retrospective study of 195 consecutive vitrectomies performed in 2001. Minimum follow up was 3 months for all cases. RESULTS: 13 patients with iatrogenic retinal breaks (6.6%) have been detected. In 8 cases the breaks affected the peripheral retina, in 4 cases they were located in the posterior pole and there was one retinal dialysis. In 4 cases there were more than one retinal break. 9 patients (70%) were vitrectomized for diabetic retinal complications. In 12 cases, the breaks were detected during surgery and treated with endolaser and/or cryoretinopexy (3 cases located inferiorly). Nevertheless 7 cases (54%) developed a retinal detachment, 2 of which could be reattached. CONCLUSIONS: Among iatrogenic retinal breaks produced during vitrectomy, the peripheral ones are slightly more frequent than the breaks in the posterior pole. Iatrogenic breaks occur more frequently in diabetic patients, having a bad prognosis and often developing a retinal detachment despite endolaser or cryoretinopexy.

Adult↗

[Potential to predict the risk of developing proliferative vitreoretinopathy with the analysis of clinical factors of regmatogenous retinal detachments].

PURPOSE: To investigate the possibility of classifying RD patients in different risk groups according to their probability of developing PVR. METHODS: This retrospective study included 298 RD patients who underwent RD surgery, with either no PVR or with PVR grade B or less. Risk factors were evaluated by single and multiple logistic regression analysis to obtain risk factors of PVR. According to the results of the regression analysis, a score was applied to the different risk factors. The sum of these scores provided a final score for each patient, which was used to divide patients in three groups according to their risk of developing PVR. RESULTS: By multiple logistic regression analysis, the following risk factors for developing PVR were identified: Preoperative PVR grade A or B, RD involving 4 quadrants, previous intraocular surgery, endolaser application, and intraocular gas injection. Three protective factors were also identified: RD in the fellow eye, postoperative ocular hypertension, and total reattachment 24 hours after surgery. Patients were divided in three groups according to their probability to develop PVR: Low risk (192 patients, 11.5% developed PVR), moderate risk (70 patients, 50.0% developed PVR) and high risk (36 patients, 80.6% developed PVR). CONCLUSIONS: It is possible to ascribe patients to a low, moderate or high risk probability of developing PVR and these data could be useful to establish a prophylactic treatment for PVR. A larger and prospective study is needed to corroborate these data and to obtain new indicators.

Female↗

Role of the intraocular irrigating solutions in the pathogenesis of the postvitrectomy retinal edema.

Alterations in the vitreo-retinal barrier can modify the exchange of water taking place between the retina and the vitreous body and cause retinal edema to develop. To verify this fact, albino rabbits were subjected to vitrectomies perfusing various intraocular irrigating solutions for various durations. The following conclusions were drawn from these experiments: Ringer's Lactate and physiological saline solutions are more edematogenous than BSS plus; the induced edema is more severe, the longer the perfusion. We have also confirmed that this edema is inhibited by topically administered indomethacin, which proves that in the rupture of blood-retinal barriers during the vitrectomy, prostaglandins play an important role.

Animals↗