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Biomedical subjects

J C Orlando

Publications and source records attributed to J C Orlando.

17 recordsLinked to original sources

Operative management and outcome of complex wounds following total knee arthroplasty.

This study describes the treatment protocol for and the outcome of the management of complex wounds around total knee replacements. An analysis of 28 patients (29 knees) with complex defects who had surgery between January 1, 1986, and July 30, 1996, was performed. A specific management protocol was applied to each knee on the basis of the size and depth of the wound, the presence of infection, and the quality of soft tissue. Primary treatment included local wound care, debridement, and skin grafting or coverage with a fasciocutaneous flap, pedicled muscle flap, or free muscle transfer. Postoperatively, knees were evaluated using the Knee Society objective score. Successful salvage of the lower extremity was obtained in 28 knees (97 percent) and of the knee prosthesis in 24 of 29 knees (83 percent). Secondary plastic surgery procedures were necessary in five knees (17 percent), and secondary orthopedic procedures were necessary in four knees (14 percent). Successful salvage of total knee arthroplasty in the presence of a complex wound requires early identification of infection, aggressive irrigation and debridement, and early appropriate soft-tissue coverage. The use of our proposed algorithm will facilitate management of these complex wounds.

Adult↗

Salvage procedures for complex soft tissue defects of the knee.

The management options for complex soft tissue defects about the knee are varied. Limb threatening conditions such as exposure of joint prosthesis or bone requires stable coverage to avoid amputation. A study was conducted to review the authors' management protocol and experience with complex defects about the knee. A retrospective analysis from 1986 to 1996 of 35 patients with complex defects about the knee was performed. Treatment options were based on the nature, size, location, and depth of the wound. A specific management protocol was applied for each patient. Treatments included local wound care, debridement and skin graft, fasciocutaneous flap, pedicled muscle flap, and free muscle transfer. Postoperatively, patients were evaluated using Knee Society objective and functional scores and other instruments to measure outcome. Successful salvage of the lower extremity was obtained in 34 (97%) patients. Salvage of the total knee prosthesis was obtained in 24 of 29 (83%) patients. Secondary plastic surgery procedures were necessary in eight (23%) patients. Secondary orthopaedic procedures were necessary in five (15%) patients. No patient required an amputation.

Adult↗

Self-reports in chronic schizophrenic patients with primary negative symptoms: preliminary results.

The Frankfurt well-being scale (FBS), an instrument for evaluating the global inner state in schizophrenic patients, was used in a pilot study with 26 chronic schizophrenic inpatients simultaneously with the Munich version of the Andreasen scale (SANS). 11 of 26 patients were able to complete the FBS questions. These patients had weaker negative symptomatology (SANS total score) and the difference was highly significant (p less than 0.01) for the score "alogia". The major goal of the investigation was to contribute to the identification of those subgroups of schizophrenic patients who are not capable of filling in a self-report questionnaire. The results suggest that self-reports of actual mood in chronic schizophrenic patients are possible only in a subgroup of patients with no more than moderate primary negative symptoms, particularly those with a low alogia score. Further efforts to evaluate the subjective well-being of chronic patients differing in severity of negative symptoms complexes, could improve methods for evaluating the effect of psychotropic drugs.

Chronic Disease↗

The immunobiology of basal cell carcinoma: an in situ monoclonal antibody study.

A semi-quantitative, immunoperoxidase monoclonal antibody technique was used to study the mononuclear cells surrounding 32 basal cell carcinoma specimens from 30 patients. Tumours were analysed in subgroups based on recurrence, size and ulceration. T cell counts were high (greater than 3 out of 4) for all groups while T helper/inducer and T suppressor/cytotoxic cell counts were equal (approx. 2). Macrophage counts were low for all groups, about I X 2, while B cell and Ia positive cell counts were high (greater than 3). T/B cell and T helper/suppressor cell ratios approached one for the tumours as a whole as well as the sub-groups. The relative importance and contribution of cell mediated vs. humoral immunity in keeping basal cell carcinomas in check is discussed.

Adult↗

Impairment of thymus-derived lymphoid cell function in patients with basal cell carcinoma.

The host-tumor relationships in 34 patients with basal cell carcinoma was investigated by characterizing thymus-derived (T) and bone marrow-derived (B) lymphoid subpopulations in the blood by cell surface markers and lymphoid function in vitro by proliferative responses to mitogenic and antigenic stimulation. Results were correlated with tumor stage. In patients with tumor present, the data demonstrate significantly (P less than .02) decreased responsiveness of T cells to the lectin mitogens phytohemagglutinin and concanavalin A, and further demonstrate significantly decreased responsiveness of T cells to antigens (P less than .001 for Candida antigen, P less than .05 for Staphylococcal filtrate and Streptococcal varidase). In patients who were grossly disease free after resection of tumors, there was no significant difference in these responses from normal. These results document, for the first time, impaired T-cell function in patients with basal cell carcinoma and suggest that the functional impairment is tumor induced.

B-Lymphocytes↗

Silicone elastomer sheeting in the development of pedicle flaps.

A "delay" of a pedicle flap stimulates improvement in the flap circulation, probably through partial ischemia. The degree of stimulation prsent at any given time is inversely proportional to the length of time that has passed after the delay because progressive revascularization across the delay lines reduces the ischemis stimulus. This revascularization can ve prevented by placing silicone elastomers (Silastic) sheeting between the flap and its bed.

Animals↗

The superomedial dermal pedicle for nipple transposition.

A new method for nipple transposition employing a superomedial dermal pedicle is described for use in reduction mammaplasty and dermal mastopexy. The advantages include superior mobility, viability, sensation and normal appearing nipples and areolae.

Breast↗