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Biomedical subjects

J C Morini

Publications and source records attributed to J C Morini.

At least 37 records · Page 2Linked to original sources
PubMed1979

Immunologic shin titration in leprosy patients and contacts.

A method of studying delayed-type hypersensitivity was developed with specific antigen in leprosy patients and contacts, measuring the dose-response curve at different lepromin concentrations. This "immunologictitration" is highly efficient for discriminating the degree of hypersensitivity reactions among the groups tested. With respect to the Fernandez reaction, the results obtained showed that there was a similar behavior in all groups studied, except in the tuberculoid group which had a more intense response, four times higher than that yielded by contacts of lepromatous patients. In the Mitsuda reaction, a similar behavior was also found among the different groups, except with respect to the reactivity intensity of contacts of lepromatous patients. Here it was demonstrated that this group had a significant depression in response to M. leprae antigen when compared with that from the other groups, independent of the degree of consanguinity or closeness to bacilliferous cases. In order to explain this immunosuppression in contacts of lepromatous patients, a hypothesis is proposed. It is suggested that changes could occur in M. leprae derived from lepromatous patients, diminishing their capacity to produce an adequate immune response.

Adolescent↗
PubMedDate not supplied

Electrocardiographic alteration among first degree relatives with serologic evidence of Trypanosoma cruzi infection. A sibship study.

To analyze whether electrocardiographic alterations (ECGA) in patients with antibodies to Trypanosoma cruzi showed a pattern of familial aggregation, a sample of 379 young adults (166 men and 213 women) distributed in sibships, were assessed for the presence of anti-T. cruzi antibodies, and subjected to a complete clinical examination and a standard resting electrocardiogram (ECG). Positive T. cruzi serology was detected in 165 individuals, 48 of them showing an abnormal ECG (overall prevalence 29%). One hundred and eleven seropositive individuals were distributed in 45 sibships, each of them constituted by more than one seropositive sib, with ECGA being present in 34 out of these patients. Seropositive subjects with ECGA were detected in 27 sibships. Since the index case within each sibship is counted exactly once, affected individuals selected at random as propositi were extracted to calculate the prevalence of ECGA among first degree relatives of probands. Abnormal ECGs were recorded in 7 out of 45 sibs yielding a prevalence that did not differ from estimations registered in the general population or seropositive sibs. Data from the present sample show no familial aggregation for the occurrence of ECGA in patients with T. cruzi. infection.

Adult↗