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Biomedical subjects

J C Mitchell

Publications and source records attributed to J C Mitchell.

At least 109 records · Page 6Linked to original sources
PubMed1977

The role of sesquiterpene lactones in contact hypersensitivity to some North and South American species of feverfew (Parthenium-Compositae).

Sixteen taxa of the genus Parthenium from North and South America and 20 sesquiterpene lactones derived from plants of the Compositae family were used for patch testing six volunteers who were known to be contact sensitive to plants and lactones of this family. The patterns of cross-sensitivity and structure-activity relationships of the allergenic lactones are evaluated and the clinical and ecological relevance is discussed.

Cross Reactions↗
PubMed1977

Multiple concomitant positive patch test reactions.

Thirty-five patients who showed 90 one plus (+) patch test reactions to 28 patch test chemicals at Day 2 (D2) were retested to the chemicals at D7. On retesting, 60% (54/90) reactions were positive but 42% (38/90) were negative at D9, suggesting that false positive patch test reactions were common when more than one positive reaction was obtained by concomitant patch testing. On retesting, the total % positivity was reduced from 344 to 241 suggesting that the true index of sensitivity was falsely exaggerated by concomitant testing.

Aged↗
PubMed1977

End-stage renal failure in juvenile diabetes mellitus: a 5-year follow-up of treatment.

A group of 43 juvenile diabetic patients accepted for renal transplantation and followed up for as long as 5 years was studied. The cumulative survivial of the group was 66% at 1 year and 58% at 5 years. The 1-year survival of those receiving cadaveric renal allografts (65%) or of those on dialysis alone (55%) was less than the survival of those after living related donor transplantation (88%). The major morbid sequelae included retinopathy, neuropathy, and peripheral vascular disease. While patients were on dialysis, blindness increased, with 44% of the bilateral blindness and 27% of the unilateral blindness representing new cases. After transplantation, permanent unilateral or bilateral blindness developed in an additional 12% of the patients. Severe neuropathy progressed rapidly in patients on dialysis and improved after transplantation in all. Fifty percent of the patients who survived transplantation 1 year or more required amputation of one or more extremities. Only 25% of the patients who survived 1 year after transplantation were without blindness, severe peripheral vascular problems, or both.

Adolescent↗
PubMed1977

Eruptive nevocytic nevi after severe bullous disease.

In two patients, hundreds of nevocytic nevi (melanocytic nevi) appeared in sites of severe bullous dermatoses that were considered to be toxic epidermal necrolysis and erythema multiforme exudativum, respectively. This phenomenon may result from benign melanocytic hyperplasia accompanying keratinocytic hyperplasia during the healing process of some of the denuded areas of the skin.

Child↗
PubMed1976

Phytophotodermatitis from Heracleum mantegazzianum.

Five individuals developed striate bullous dermatitis two days after exposure on a clear day to Heracleum mantegazzianum, Umbelliferae (Parsnip) family. Photopatch testing confirmed phototoxicity from the plant. This and 28 other Heracleum species yield linear furanocoumarins.

Adult↗
PubMed1976

Contact hypersensitivity to sesquiterpene lactones in Chyrsanthemum dermatitis.

In six persons with contact allergy to chrysanthemum of florists, patch tests were performed with 25 sequiterpene lactones. Positive responses were observed to 15 lactones. The most frequently encountered positive responses were to alantolactone (positive in all cases) and to arbusculin A, 8-deoxycumambrin, ambrosin, damsin and psilostachynin. The findings corroborate the assumption that an alpha-methylene group attached to the gamma-lactone ring is an essential prerequisite for allergenic activity of sesquiterpene lactones. Pyrethrum produced a positive reaction in one of the patients, pyrethrins gave negative reactions in all. Some of the chrysanthemum patients were also hypersensitive to turpentine and colophony and to garlic, primin and tars.

Adult↗
PubMed1976

Disabled counselors: perception of their effectiveness in a therapeutic relationship.

It has not been delineated how a disabled person is viewed when interacting with another person. The present study investigated subject perception of a counselor in a wheelchair who was seen in a video-taped counseling interview. Subject degree of body satisfaction was measured to assess the importance of this variable in the perception. Evaluation of the counselor was by the Barett-Lennard Relationship Inventory that measures four dimensions of a relationship: emphatic understanding, positive regard, unconditional regard and congruence. Results suggest that a counselor in a wheelchair is perceived more favorably than an able-bodied counselor along three of these dimensions and female subjects perceive him more favorably than male subjects do. Degree of body satisfaction does not seem to be a factor in this perception.

Attitude to Health↗
PubMed1976

Serum lipids in chronic renal failure.

The serum lipids and lipoprotein patterns in 100 adult patients with nonnephrotic chronic renal failure were analyzed retrospectively. Hypertriglyceridemia was found in 43% of these patients. Forty-nine of the 100 had a normal lipoprotein pattern, whereas 42 had type IV hyperlipoproteinemia. This abnormal lipoprotein pattern could not be correlated with the degree of renal impairment, the type of renal disease, or with the patient's age, sex, weight, or diet.

Adult↗