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Biomedical subjects

J C Meek

Publications and source records attributed to J C Meek.

At least 37 records · Page 2Linked to original sources
PubMed1977

The insulin receptor in myotonic dystrophy.

Insulin binding was studied using circulating monocytes obtained from seven patients with myotonic dystrophy and seven control subjects. During an oral glucose tolerance test the 2 h plasma glucose value was significantly higher in patients with myotonic dystrophy compared to controls, and 5 out of the 7 patients demonstrated hyperinsulinemia. This combination of abnormal glucose tolerance and hyperinsulinemia suggests insulin resistance. There was no difference in insulin binding to monocyte receptors between the two groups. These results suggest that no abnormality exists in the insulin receptor in myotonic dystrophy.

Adolescent↗
PubMed1975

Hypothyroidism.

We found biochemical evidence of hypothyroidism (low T3 and T4 and elevated TSH) in azotemic patients. Hemodialysis did not correct the hypothyroidism but renal transplantation did. The hypothyroidism is probably a consequence of impaired thyroidal elaboration of thyroid hormone, as well as decreased peripheral conversion of T4 to T3. The impaired thyroidal gland function may be secondary to the increased concentration of aryl acids found in chronic renal disease.

Blood Urea Nitrogen↗