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Biomedical subjects

J C Legrand

Publications and source records attributed to J C Legrand.

At least 127 records · Page 7Linked to original sources
PubMedDate not supplied

Antimicrobial therapy for intra-abdominal infections: guidelines from the Infectious Disease Advisory Board (IDAB).

Intra-abdominal infection is a common cause of severe sepsis in a hospital setting and remains associated with a significant morbidity, mortality and resource use. Early adequate surgery or drainage remain the cornerstones of intra-abdominal infection management and impact on patients outcome. Concomitant early and adequate empiric antimicrobial therapy further influences patients morbidity and mortality. Multiple empirical regimens have been proposed in this setting, but rarely supported by well designed, randomized-controlled studies. The current manuscript summarizes the recommendations of the Infection Disease Advisory Board on the management of intra-abdominal infections. Empiric antimicrobial therapy for the most common causes of abdominal infections is proposed. In addition, particular attention has been paid on antibiotic treatment duration.

Abdominal Abscess↗
PubMedDate not supplied

[The quest of quality in the field of infectious disease at the hospital].

The implementation of a quality program in the field of the infectious diseases requires the prior definition of criteria (efficacy, low toxicity, low cost, less emergence of resistant strains) but also the target (the patient it-self, his or her community, the health system as a whole). A lot of tools are questioned: antimicrobial policy (escalation/streamlining, restricted formularies, antibiotics rotation), guidelines, relational tools (booklets and CME, prescription's formularies, computer's help and the Web) but also the role of an infectious diseases specialist and an antimicrobial management team. Finally, we outline some processes of evaluation.

Anti-Bacterial Agents↗
PubMedDate not supplied

Salmonella endarteritis, about two cases and their management.

Mycotic aneurysms due to Salmonella are a classical but uncommon complication of Salmonella infections. We report two cases of such aneurysms, the first one having developed two successive aneurysms of the iliac arteries due to Salmonella typhimurium. The literature on Salmonella endarteritis is briefly reviewed. The importance of an aggressive surgical approach of the mycotic aneurysm, with removal of all infected material and extra-anatomic bypass through contaminated tissue is emphasized. The role of antibiotic treatment is also discussed.

Aged↗
PubMedDate not supplied

[Malignant tumour of adrenal with feminizing syndrome and primary hyperaldosteronism (author's transl)].

Feminizing tumour of adrenals are rare. Gynecomasty, abdominal tumour are the more frequently observed symptoms. The described case in a 38 years aged man is of special interest because of association with primary hyperaldosteronism. Studies in vivo and in vitro are reported. In vitro studies shown a high 18 hydroxylation biosynthetic activity of tumoral fragment and a great synthesis of polar phenolsteroids with testosterone as precurseurs.

Adrenal Cortex Neoplasms↗