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Biomedical subjects

J C Lane

Publications and source records attributed to J C Lane.

At least 37 records · Page 2Linked to original sources
PubMed1982

Antidiuretic hormone responses to eucapnic and hypocapnic hypoxia in humans.

Urinary excretion rate of antidiuretic hormone (UADHV) was studied in male volunteers in response to hypobaric hypoxia. The first series consisted of three groups. The chamber was decompressed to 465, 495, and 438 Torr during high-altitude (HA) exposure for groups I (n = 5), II (n = 5), and III (n = 4), respectively. In group I, the chamber air contained 3.77% CO2 to prevent alkalosis. The level of hypoxemia was similar in groups I and II. Mean 24-h UADHV was unchanged in group I, but increased 96% (P less than 0.05) and 180% (P less than 0.05) in groups II and III, respectively, on day 1 at HA and was normal during subsequent days at HA regardless of symptoms of acute mountain sickness. Shorter sampling intervals employed in a second series of experiments conducted at 495 Torr revealed a twofold increase in UADHV (P less than 0.05) 8-12 h after ascent in eight asymptomatic subjects; UADHV returned to base line within 9 h and remained low. The symptomatic subjects both had increased UADHV (3- and 8-fold from base line) between 2 and 4 h after ascent. Increased UADHV in asymptomatic subjects may be a result of the concomitant decrease in plasma volume, both of which appeared to be eliminated by CO2 supplementation.

Adult↗
PubMed1977

Post-mortem blood alcohol in general aviation pilots.

Blood alcohol concentrations are reviewed from a series of 250 consecutive fatal accidents, involving 259 pilots, for the years 1962 through 1975. BACs were obtained in 150 of 213 fatally injured pilots whose bodies were recovered. Positive BACs were 18% of total estimations. Impairment by alcohol was probably a factor in about 9% of accidents in which valid BACs were obtained. These percentages are not significantly different from lumped U.S. data. Comparison with fatal accidents in other modes of personal transportation shows alcohol plays a part in the following descending order: cars in single-vehicle accidents, all cars, motorcycles, general aviation aircraft.

Accidents, Aviation↗
PubMed1975

Probability of casualties in an airport disaster.

World airline accident statistics for the period 1960 to 1970 indicate the number of seriously, but nonfatally injured is unlikely to exceed 25% of the occupant capacity of the largest aircraft using an airport. In only 1 accident out of 20 will this number be an underestimate. This estimate may be of value in medical planning for an airport disaster and in the assessment of loads on hospitals.

Accidents, Aviation↗