[Post-traumatic epilepsy].
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Anticonvulsants↗
Biomedical subjects
J C Justafré
Publications and source records attributed to J C Justafré.
Relationships between brain concentrations of desipramine and paradoxical sleep inhibition in the rat.
Desipramine (DMI), like many antidepressant drugs, inhibit the production of paradoxical sleep (PS). In the present experiment, we have investigated the relationships between brain level of DMI and PS inhibition. Groups of rats had their sleep monitored after 1, 2 or 4 mg/kg of DMI. In other animals, the brain concentration of DMI was assayed at various times after the same treatments. The results indicate that a critical threshold concentration of 300 ng/g DMI in the brain is necessary for complete PS inhibition. This stage reappears only when the DMI level falls below this value, and its production resumes at a normal rate, provided the DMI level reached initially was not largely in excess of the threshold concentration. The results are discussed with regard to the present knowledge of specific binding of tricyclics in brain and their "ex vivo" action on norepinephrine uptake resulting in enhancement of collateral inhibiton of noradrenergic cells.
Animals↗
[Effect of glycerol on cerebral infarct].
Intravenous administration of glycerol under double-blind conditions (25 g twice daily for 6 days) to 26 patients with cerebral infarction localized in the territory of the middle cerebral artery temporarily improved the clinical evolution, as assessed by a scoring system, in comparison with 25 patients receiving placebo infusions.
Aged↗
Intravenous glycerol in cerebral infarction: a controlled 4-month trial.
A double-blind, randomized trial was performed with 51 patients suffering from focal ischemic lesions in the territory of the middle cerebral artery. Intravenous infusions of 10% glycerol in 0.9% NaCl--5% glucose solutions were administered twice daily for 6 days to 26 patients, and the same amount of NaCl--glucose solutions to 25 controls. Glycerol did not reduce mortality (9 deaths in each group). The functional recovery was assessed by repeated neurological examinations during the 4 month trial. Glycerol significantly improved global performances and motor and sensory functions in patients with moderate disability, but its effect on global performances was transient. The patients with severe disability were not improved at all.
Aged↗