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Biomedical subjects

J C Job

Publications and source records attributed to J C Job.

At least 73 records · Page 4Linked to original sources
PubMed1987

[Effects of bromocriptine on bone maturation in tall adolescents. Comparison of the Greulich-Pyle and Tanner TW 2 RUS methods].

The effect of bromocriptine 7.5 mg/day for 8 to 14 months on bone maturation has been studied in 33 excessively tall adolescents (25 females and 8 males aged 11 to 16 years, at pubertal stages P2 - P3), using comparatively the atlas of Greulich and Pyle and the RUS method of Tanner and Whitehouse. With the Greulich and Pyle evaluation, bone age was very significantly increased during treatment: p less than 0.001 in females, p less than 0.01 in males. The RUS method gave significantly greater evaluation of bone age (p less than 0.001), so that the treatment-induced acceleration of bone maturation was less significant: p less than 0.01 in females, NS in males. These data confirm that bromocriptine in constitutionally tall adolescents acts mainly through an increase of pubertal bone maturation. Moreover they point out once again the difficulties and discrepancies of height prediction.

Adolescent↗
PubMed1986

Effects of human growth hormone administration on growth rate and growth-stimulating activity of serum, measured by lymphocyte bioassay in hypopituitary children.

The acute effect of human growth hormone (hGH) upon the serum bioassayable growth-stimulating activity was compared to the long-term effects of hGH on growth rate in two groups of hypopituitary patients aged 2-18 years. 12 patients had complete GH deficiency with GH peak below 3.5 ng/ml at two stimulation tests. 15 others, having both GH peaks below 8 ng/ml and at least one above 3.5 ng/ml, were considered as having partial GH deficiency. The growth-stimulating activity of serum was measured by its effect at concentrations 0.03 to 1.25% upon thymidine incorporation into lectin-activated normal human lymphocytes, named thymidine activity (TA). In patients with complete GH deficiency, the pre-treatment TA was positively correlated with the peak response of GH to stimulation tests. The increase of TA after 3-4 days of hGH treatment was positively correlated with the pretreatment TA level, and negatively correlated with the peak GH level. The effect of a 6-12 months therapeutic course of hGH upon the growth rate was positively correlated with the acute increase of TA. No such correlations were found in patients with partial GH deficiency. Many works have discussed the relationship of acute somatomedin responses and long-term clinical results of treatment with hGH in GH-deficient children. The present data, using a highly sensitive bioassay of serum stimulating activity, suggest that the degree of GH deficiency is an important factor to be considered. The response of GH-dependent serum growth factors to acute treatment with hGH could have more predictive value in cases with total lack of growth hormone than in cases of partial deficiency.

Adolescent↗
PubMed1986

Hyperfunctioning thyroid nodules in children and adolescents.

Eight children and adolescents, seven female and one male, aged 7.1 to 15.0 years, referred over a 12-year period for a solitary mass in an otherwise normal thyroid gland, exhibited a hyperfunctioning nodule on thyroid scintiscan. Tracer uptake in the surrounding thyroid tissue was reduced or completely suppressed, but could be restored after TSH stimulation. Only one patient had mild clinical hyperthyroidism with normal T4 but increased T3 serum levels and blunted TSH responsiveness to TRH. A similar hormonal pattern suggestive of subclinical hyperthyroidism was found in three other subjects who were clinically euthyroid. One patient initially euthyroid progressed to subclinical hyperthyroidism two years later. In the whole group a significant negative relationship was found between serum T3 level and TRH-stimulated TSH peak (r = -0.829, p less than 0.02). All the patients underwent selective surgery after a 3-month to 2-year period of follow-up. Microscopic examination was consistent with adenoma in seven patients, while in one case a well-encapsulated papillary adenocarcinoma was found. Though hyperfunctioning nodules are seldom malignant, their surgical removal must be recommended when they become thyrotoxic, exceed 3 cm or show progressive enlargement.

Adenocarcinoma↗
PubMed1986

Plasma growth hormone releasing factor levels in children: physiological and pharmacologically induced variations.

Plasma growth hormone releasing factor (GHRH) was measured by RIA in the plasma of 41 children with constitutionally short stature. Basal plasma GHRH was 51 +/- 10 pg/ml. L-Dopa induced a 2-fold increase in circulating GHRH 30-45 min before the elevation of GH. A positive correlation (p less than 0.005) was found between the peak of GH and GHRH during the dopaminergic stimulus. On the opposite, the secretion of GH induced by amino acids or clonidine is not preceded by an elevation of plasma GHRH. When a release of GH appeared after the insertion of the venous catheter alone, probably due to the stress, it was preceded by a rise of plasma GHRH. In four sleeping adolescents during the night no relationship was found between the peaks of plasma GHRH and the peaks of GH secretion. These results suggest that the various stimulations of GH secretion used for investigations of a short stature do not act in the same way at the hypothalamo-pituitary level.

Amino Acids↗
PubMed1986

Serum somatomedin C, bioassayable growth-promoting activity (thymidine activity), and transferrin in human fetuses: in utero study.

Serum somatomedin C, thymidine uptake stimulating activity, and transferrin were measured in fetal blood collected by ultrasound-guided puncture of umbilical vessels in utero during prenatal assessment for mother-to-fetus transmissible infections. Serum somatomedin C and transferrin were measured by immunoassay. Thymidine activity was measured by assay of [3H]thymidine incorporation into lectin-activated human lymphocytes. Studies were conducted in 48 healthy fetuses at gestational ages 21-28 wk. From 21-24 to 25-28 wk, serum somatomedin C significantly increased from 0.05 +/- 0.06 to 0.24 +/- 0.03 U/ml, while thymidine activity significantly decreased from 1.41 +/- 0.15 to 0.95 +/- 0.06 U/ml. Transferrin levels did not change. These data suggest that the humoral control of fetal growth at midpregnancy involves mechanisms other than direct regulation by somatomedin.

Biological Assay↗
PubMed1986

Frequency of hypoglycemia in children with adrenal insufficiency.

The frequency of hypoglycemia in 165 children with primary adrenal insufficiency, 118 of whom had Congenital Adrenal Hyperplasia and 47 Addison's Disease, was 18%. Half of the hypoglycemic episodes occurred in the neonatal period. Hypoglycemia was isolated in 13 children, revealing the disease in 4 newborns with Congenital Adrenal Hypoplasia and in a boy with 11 B Hydroxylase deficiency. Basal plasma cortisol levels were significantly lower in those of subjects who experienced hypoglycemia (47.1 +/- 28.6 ng/ml vs. 106.0 +/- 86.6 ng/ml, p less than 0.001). A significant correlation (p less than 0.001) was found between the plasma concentration of glucose and cortisol at time of hypoglycemia.

Addison Disease↗
PubMed1986

[Growth of anorexic adolescents].

Growth and puberty were studied in 19 children with anorexia nervosa (15 girls and 4 boys), the onset being before puberty or in its early stages. Growth retardation reached 2.04 +/- 1.39 SD, with important individual changes and for some patients a prolonged interruption of growth. Seventeen of 19 patients presented delayed puberty, and in some, hypogonadism persisted after recovery from anorexia nervosa. Endocrine investigations concerning the pituitary somatotropic (GH) and gonadotropic (FSH, LH) secretions, as well as gonadal steroids showed highly variable changes from one patient to another and even variations in the same patient from one test to another. However, no correlation could be found between the hormonal abnormalities and the degree or length of undernutrition. Some patients recovered normal endocrine function when they reached an adequate weight, others kept a lasting deficiency. The endocrine impairment in anorexia, well known in adults, is probably more severe in adolescents.

Adolescent↗
PubMed1986

[Treatment with human growth hormones in 1986].

The availability of large supplies of synthetic human growth hormone (hGH) and somatocrinin (GRF) may lead to new therapeutic possibilities, however still hypothetical. This review briefly summarizes the main data previously acquired with extracted hGH in medical practice: clinical pharmacology, long-term results in completely GH-deficient children, short-term results in partial or atypical GH deficiency and in some other types of severe growth retardation. The data reported up to now (July 1986) from clinical trials using synthetic hGHs and GRF are preliminary. However they allow to discuss guidelines for the new trials, unavoidably long and accurately designed, which are needed for extending and delineating the clinical use of new human growth hormones.

Growth Hormone↗
PubMed1986

[Comparison of the secretion of growth hormone during sleep and after pharmacologic stimulation. Results of treatment with hGH in cases of dissociated secretions].

Maximal response (peak) of growth hormone (GH) after conventional pharmacologic stimuli have been compared to maximal level reached during sleep in 215 children (123 prepubertal, 92 early pubertal) (group A). A weak correlation (r = 0.37, p less than 0.001) was observed. Five sub-groups of patients could be distinguished according to their GH pharmacologic or sleep peaks: 115 with normal secretion in both cases (I), 10 with complete deficiency (II), 27 with partial deficiency (III), 34 with normal GH sleep secretion and low responses to stimuli (IV) and 29 with the inverse situation (V). A second group (B) of 30 very short children (17 prepubertal and 13 early pubertal) had borderline or variable responses after several pharmacologic stimuli. hGH therapy was done to every patients of sub-group A II, 12 of sub-group A III, 9 of subgroup A IV, 5 of sub-group A V and every one of group B. A sharp rise of growth rate has been obtained with hGH in every patients of sub-groups A II and A III, in 10 out of 14 patients of sub-groups A IV and A V and in almost all patients of group B. A sharp rise of growth rate has been obtained with hGH in every patients of sub-groups A II and A III, in 10 out of 14 patients of sub-groups A IV and A V and in almost all patients of group B. hGH effect in the three last kinds of patients, with atypical GH secretion, was better in those who were in early puberty.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1986

[Natural history of intrauterine growth retardation: pubertal growth and adult height].

The evolution of height and bone age up to complete or near complete achievement of growth has been followed in 13 children born at term with a length of 42 to 46 cm, who after age 2 years had still a growth delay of -2.1 to -4.9 SD. Their mean annual growth velocity has been slightly below the average, excepted in the years preceding and following immediately the onset of puberty. The bone age, largely delayed and close to height age up to approximatively 8 years, afterwards has increased more than growth, so that the final height has always been less than the adult height predicted at age 8 years. The main factor in this difference between final and predicted height has been the fact that puberty has not been delayed. Starting at the usual age, in children whose height deficiency was still important, the pubertal growth spurt has not allowed full catch-up. Thus, in spite of delayed bone age during childhood, the mean adult height in the 13 patients of this series has been -3.43 SD versus -3.16 SD at age 2-5 years, these mean values involving different individual growth curves with absolute deterioration in 6 only of the 13 cases. These data will have to be considered when discussing the final results of therapeutic trials in children with severe and persisting intra-uterine growth retardation.

Adolescent↗
PubMed1986

[Middle-term course of craniopharyngiomas in children as a function of initial therapeutic choice].

Despite numerous studies and publications, the treatment of craniopharyngiomas in children remains controversial. The present series of 33 cases, followed for the last 10 years, is analysed according to therapeutic protocols jointly defined, case by case, from each patient's features and in restricting the extent of surgical excisions. In agreement with other recently published series, two options give superior results: complete excision, when the risk is low; in the other cases, partial excision or rather a simple biopsy or decompression, followed by irradiation. Risks of relapse are thus quite reduced and mortality greatly reduced. The unavoidable consequence of hypopituitarism is easily treated. However, the frequency of psychic and/or neurologic sequellae as well as the risk of post-radiation complications should not be disregarded when selecting treatment.

Adolescent↗
PubMed1985

Antigonadotropic cell antibodies in the serum of cryptorchid children and infants and of their mothers.

An indirect immunofluorescence test allowed us to study circulating antigonadotropin-cell antibodies in patients with cryptorchidism. Antigonadotropin-cell activity was found in the serum in 14 of 23 cryptorchid boys aged 1 to 11 years and in 12 of 23 infants aged 1 to 3 months; in most of them the antibodies persisted during short-term follow-up. Results of paired study of the mother and infant were concordant in 14 of 15 cases. No such antibodies were found in 24 control male children. These data support the possible role of pituitary autoimmunity in the child and the mother as a factor in testicular maldescent. We found no correlation between the presence or absence of antibodies and the partial luteinizing hormone-Leydig cell deficiency usually found in cryptorchidism.

Adolescent↗
PubMed1985

Effects of gonadotrophin-induced elevation of serum testosterone upon somatomedin C levels and serum thymidine activity in children.

3H-thymidine uptake into lectin-activated human lymphocytes allows to measure a growth-stimulating activity of serum, the thymidine activity (TA), which is GH dependent in vivo and related to somatomedins (Sm). In this work, it is shown: that addition of human chorionic gonadotrophin (HCG) or testosterone in vitro does not increase the 3H-thymidine uptake into lymphocytes; that the gonadotrophin-induced elevation of testosterone in children is accompanied by a significant increase of TA and, at a lesser degree, of Sm C; that these two increases are significantly correlated, and that the age-related variation of TA and Sm C after HCG stimulation test are not parallel.

Adolescent↗