In 17 hypopituitary prepubescent children (14 males and 3 females), aged 14.5 +/- 2.1 years, treated for more than 2 years with human growth hormone (hGH), with bone ages of 10.4 +/- 1.4 years and plasma dehydroepiandrosterone (DHA and/or DHA-S) levels lower than the normal values for bone age, low dose androgen therapy (norethandrolone 0.25 mg/kg/day 2 of 3 months) was added to the previous treatment. The speed of growth doubled during the first six months of associated treatment. For 15 patients so treated for one year,the height gain was 7.5 +/- 1.56 cm versus 4.47 +/- 1.2 cm the preceding year. During this first year of treatment, bone age, on an average, progressed less quickly than height. The combination of hGH and low grade androgenic steroid therapy allows for the acceleration of the growth in height without increasing the doses of hGH. A prolonged controlled trial of this therapy in hypopituitary prepubescent children with bone age of at least 8 years and known deficiency of androgenic secretion by the adrenal glands is suggested.

Adolescent↗

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[Congenital virilizing adrenal hyperplasia due to 11 beta-hydroxylase deficiency. Study of eleven cases (author's transl)].

Eleven cases of congenital virilizing adrenal hyperplasia are studied. This study leads to point out some peculiar characteristics: virilization of external genitalia in girls is most usually important; arterial hypertension is delayed, usually after some years; plasma androgens and desoxycortisol are highly elevated; plasma 17-hydroxyprogesterone is slightly elevated and this may be misleading; good results of treatment which must preferably use hydrocortisone since plasma cortisol is sometimes low; long-term risks in treated children include chronic hypertension in both sexes, advanced puberty in girls and pubertal gynecomastia in boys.

Adolescent↗

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[The progeny of women with treated congenital hypothyroidism (author's transl)].

The progeny of 11 women with treated congenital hypothyroidism was studied. They had 17 pregnancies that led to 2 spontaneous abortions, 2 children dead in the first month after birth, and 13 living children. These 13 children have a normal psychomotor development. One of them has a lingual ectopic thyroid as her mother, one has a congenital cardiac defect, one has a minor anomaly of toes. The authors add a previously reported familial case of hypothyroidism in a mother and her four children.

Congenital Hypothyroidism↗

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[Puberty and adult height in congenital virilizing adrenal hyperplasia (author's transl)].

A study of 52 pubertal patients having been treated for virilizing adrenal hyperplasia (38 females and 14 males) leads to emphasize the importance of the precocity and accuracy of treatment. In patients with delayed treatment, mainly when they are girls, an advanced or true precocious puberty will increase the advance of bone age and reduce adult height. But, whatever be the time of onset of treatment and of pubertal achievement, no important or sustained sexual improvement was found in patients receiving a well-controlled treatment.

Adolescent↗

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[Growth hormone deficiency in children. Diagnostic methods].

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Child↗

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[Isolated breast prematurity in young girls].

The clinical and follow-up data of the isolated premature thelarche are reviewed in a series of 61 girls aged 6 months to 6 years. Transitory increase of plasma estrogens was observed in some cases. The results of LHRH test were similar to those from normal girls of the same age. Premature thelarche could be a normal variant in girls, related with the physiologic unsteadiness of the prepubertal female pituitary-gonadal axis.

Age Determination by Skeleton↗

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[Benign unilateral testicular hypertrophy beginning at puberty].

Two normal boys, with no previous history, were referred at the onset of puberty for unilateral testicular hypertrophy. Radiological and biological investigations, and in one case testicular biopsy, ruled out cellular proliferation or tumor. Except for FSH level slightly above normal in one case, no endocrine abnormality was found. This is a rare, and probably non pathologic event.

Adolescent↗

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[Results of treatment with human growth hormone in childhood].

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Child↗

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[Primary amenorrhea in adolescent girls. Incidence of isolated delayed menarche].

In its strict meaning, primary amenorrhea is defined as the absence of any menstruation in a young girl without genital malformations who has reached her complete morphological development. Twenty-four cases corresponding to this definition, with bone ages of at least 15 years, breasts for at least 2 years, and adult type pubic hair were examined. In only 10 could a cause be found: anorexia nervosa, slight hyperandrogenism, acquired intracranial lesion. The other 14 girls, mean age of 16.2 +/- 1.4 years, were considered as presenting with simple delayed menarche. They were not given treatment, although 4 of them had been given steroids in artificial cyclical form previously. The 8 who were followed finally spontaneously developed normal cycles at a mean age of 17.6 +/- 2.8 years, one not until 24 years. Such data should lead to avoiding unnecessary treatments.

Adolescent↗

PubMedDate not supplied

[Early treatment of congenital hypoplasia of the penis with intramuscular delayed-action testosterone].

Three intramuscular injections of 25 to 50 mg of testosterone hexahydrobenzoate were prescribed in 37 boys who presented with hypoplastic penis: 16 with micropenis and normally placed urethra, 21 with hypospadias. Ages ranged from 4 months to 9 years. In almost all children treated between the ages of 6 and 18 months, penis growth became normal for age. Growth and bone maturation were temporarily accelerated but in a parallel fashion, so that this very early androgen-therapy need not reduce the adult height of children thus treated.

Age Factors↗

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[Final results of treatment with human growth hormone].

The authors report the results of treatment with human growth hormone (hGH) (for 3 1/2 years to 11 3/4 years, mean: 5 years 4 months) in 34 children presenting with complete growth hormone deficiency and an average growth failure reaching 3.9 standard deviations (SD). Treatment was discontinued, after spontaneous or induced puberty, when bone age reached or was beyond 15 years in boys, and 13 years in girls. A partial correction was obtained in almost all cases. However, average height remained at -2.4 SD with respect to age and -1.75 with respect to bone age, reaching normal limits in only half of the patients. School and professional performances were not appreciably different from those which are observed in normal adolescents. Although the acceptance of the diagnosis and therapy was not always good, the medical support associated with the supervision of the treatment seems to have had a favourable psychological effect.

Adolescent↗

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[Relationships between growth, and plasma growth hormone and growth factors under normal physiological conditions and during pathological states (author's transl)].

Growth hormone (GH) and somatomedin (Sm) are the main factors of human growth. Sm is GH-dependent, but Sm increase after hGH injection in hypopituitary dwarfs is slow, and preceded by a decrease. The liver and kidneys are the main places of Sm production in vivo, the liver having probably also a regulatory effect. In vitro, GH-dependent production of Sm may be obtained from fibroblasts as well as from liver cells. Sm activates thymidine uptake by cultured human fibroblasts and by activated human lymphocytes, this effect needing cofactors from serum. Discrepant correlations between growth, GH and Sm are found in some pathological situations, such as obesity, craniopharyngioma, celiac disease, infantile malnutrition. Moreover, transferrin, a plasma protein, correlates also with growth.

Dwarfism↗

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[Follow-up of adolescents with Turner syndrome].

BACKGROUND: Adult women suffering from Turner's syndrome were born too early to have been treated with growth hormone. Most of them are not familiar with the results of the new methods of reproductive medicine. It is thus useful to know their long-term development after their adolescence. PATIENTS AND METHODS: A questionnaire was sent to 107 young Turner women aged 18 to 35 years. It included data on their level of education and qualification, their social, familial and professional accomplishments, their sentimental and sexual status, their housing and their leisure activities, their opinion of themselves and of the treatment they had received. RESULTS: The mean subject height was 144.5 +/- 6.9 cm (range: 130-160 cm); 50% had received an advanced education and only 1 patient suffered from mental retardation. 40% had a steady employment and 34% were still at school. 13 of the 44 patients who responded had normal sexual lives. 92% were interested in reading, movies, theater or music. CONCLUSIONS: These adults have overcome the difficulties resulting from their handicaps and are successful in their adaptation to the adult society. This is due to their intelligence and personalities.

Adolescent↗