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Biomedical subjects

J C Javitt

Publications and source records attributed to J C Javitt.

90 records · Page 5Linked to original sources
PubMed1991

National outcomes of cataract extraction. I. Retinal detachment after inpatient surgery.

Rehospitalization for retinal detachment (RD) was studied in 338,141 Medicare beneficiaries older than 65 years of age who were undergoing inpatient cataract extraction in 1984. Extracapsular cataract extraction (ECCE) was performed in 60% of patients, intracapsular cataract extraction (ICCE) in 31%, and phacoemulsification in 9%. The risk of rehospitalization for RD within 4 years of ICCE was 1.55% over 1.5 times the risk associated with ECCE (0.9%). The risk of RD after phacoemulsification was 1.17%. Cataract surgery accompanied by anterior vitrectomy was associated with a 5.0%, likelihood of RD at 4 years, which is 4.5 times greater than that for cataract surgery alone (1.12%). White patients were 1.7 times more likely to be rehospitalized for RD than were black patients (1.15% versus 0.67%; P less than 0.001). In both races, younger patients were more likely to be rehospitalized for RD than were older patients (P less than 0.001). While the increased rate of RD after ICCE versus ECCE confirms previously held clinical beliefs, the increase in the risk following phacoemulsification (P less than 0.0001) has not been reported previously.

Aged↗
PubMed1991

Transscleral cyclophotocoagulation of human autopsy and monkey eyes.

We studied the effect of uveal pigmentation on contact Nd:YAG transscleral cyclophotocoagulation in 36 human autopsy and eight cynomolgus monkey eyes. Ten autopsy eyes from black individuals required less energy to create a lesion than 23 eyes from whites. The mean lesion diameter at the posterior pars plicata was similar in all these eyes; however, the mean energy required was 4.4 J in the black and 6.4 J in the white eyes. Transscleral cyclophotocoagulation lowered intraocular pressure (IOP) in four monkey eyes with elevated IOP, but did not in four other eyes without elevated IOP. Treatment over conjunctival pigmentation burned the conjunctiva, even at the lowest energy tested (3.5 J). Contrary to other investigators' findings, transmission electron microscopy showed at least short-term loss of scleral architecture in both the human autopsy and monkey eyes.

Animals↗
PubMed1991

Detecting and treating retinopathy in patients with type I diabetes mellitus. Savings associated with improved implementation of current guidelines. American Academy of Ophthalmology.

Diabetic retinopathy is the leading cause of acquired blindness among Americans of working age. The resulting economic and societal burdens are of profound magnitude. Epidemiologic and clinical trials data were used to analyze the impact of improved recruitment of patients with Type I diabetes mellitus into screening and treatment programs. The analysis predicted annual savings of $101.0 million and 47,374 person-years-sight at the currently estimated 60% screening and treatment implementation level. If all patients received appropriate eye care, the predicted savings exceed 167.0 million and 79,236 person-years-sight. Approximately two thirds of all savings result from treatment of proliferative diabetic retinopathy, while nearly one third arises from treatment of clinically significant macular edema. Additional savings of $9571 are realized with each recruitment of a newly diagnosed patient with diabetes. Initiating screening immediately upon diagnosis of diabetes, rather than the currently recommended 5-year deferral, would be cost effective if 1 additional individual in 56 were recruited. This model suggests that improved delivery of ophthalmic care to patients with diabetes would yield substantial financial and visual savings, thus making major recruitment programs such as the National Eye Institute's National Eye Health Education Program and the American Academy of Ophthalmology's Diabetes 2000, both economically and clinically effective.

Adult↗
PubMed1991

Improved detection and referral of patients with diabetic retinopathy by primary care physicians. Effectiveness of education.

We studied the effect of a 4-hour course in recognition and management of diabetic retinopathy on the ability of nonophthalmologist physicians to detect and to appropriately refer patients with sight-threatening diabetic retinopathy. Participants completed a written examination covering case management and performed a total of 340 dilated ophthalmoscopic examinations on selected patients before and 2 weeks following the teaching session. Accuracy of ophthalmoscopy was assessed by comparison with standardized grading of fundus photographs. Scores on the written examination increased from a mean of 49% to 78% correct. The likelihood of failing to detect and appropriately refer patients with proliferative or preproliferative retinopathy decreased from 60% to 15%. Similarly, for patients with maculopathy, the likelihood of failure to detect and to appropriately refer decreased from 83% to 15.6%. These data suggest that education may significantly improve the ability of nonophthalmologists to detect and to appropriately refer patients who are at risk for vision loss.

Attitude of Health Personnel↗
PubMed1990

Ab interno laser sclerostomy in aphakic patients with glaucoma and chronic inflammation.

Five patients with aphakia, glaucoma, and chronic inflammation were treated with ab interno sclerostomy by using the continuous wave Nd:YAG laser focused through a sapphire probe. After a follow-up period of 24 to 28 months, three of five patients had good intraocular pressure control. The sclerostomy failed in one patient when it was occluded by vitreous. The second failure was attributed to closure of the sclerostomy because of chronic intraocular inflammation.

Aged↗
PubMed1990

Acquired pits of the optic nerve. Increased prevalence in patients with low-tension glaucoma.

The authors studied 232 glaucoma patients in an attempt to shed light on the implications of the pit-like localized cupping of the optic nerve often referred to as an "acquired pit of the optic nerve" (APON) both in low-tension glaucoma and in glaucoma associated with elevated intraocular pressure (IOP). Twenty (74%) of the 27 patients with low-tension glaucoma had APONs, whereas 31 (15%) of the 232 patients with elevated pressure did (P less than 0.001). Overall, there was no difference between the degree of field loss in patients with APONs and in those without. We suggest that APONs may signal an abnormal susceptibility of the optic nerve to the damaging effects of IOP.

Glaucoma↗
PubMed1990

Detecting and treating retinopathy in patients with type I diabetes mellitus. A health policy model.

Diabetic retinopathy is the major cause of new cases of blindness among working-age Americans. The authors analyzed the medical and economic implications of alternative screening strategies for detecting retinopathy in a diabetic population. The approaches compared included dilated fundus examination at 6-, 12-, and 24-month intervals with and without fundus photography. Potential savings from screening and treatment are based on amounts paid by the federal government for blindness-related disability. Screening for and treating retinopathy in patients with type I diabetes mellitus was cost-effective using all screening strategies. Between 71,474 and 85,315 person years of sight and 76,886 and 94,705 person years of reading vision can be saved for each annual cohort of patients with type I diabetes mellitus when proper laser photocoagulation is administered. This results in a cost savings of $62.1 to $108.6 million. Annual examination of all diabetic patients and semi-annual examination of those with retinopathy was more effective than annual examination with fundus photography. This screening strategy is consistent with the Preferred Practice Pattern for Diabetic Retinopathy of the American Academy of Ophthalmology.

Adolescent↗
PubMed1989

A modified slit lamp for examination of wheelchair-bound patients.

A standard slit lamp can be modified with readily available components to examine wheelchair-bound patients. This modification minimizes discomfort in transferring patients to an examination chair and may provide better patient positioning in some cases. In addition to saving staff time, this technique minimizes the disconnecting of intravenous tubing, drainage catheters, and similar appliances. The addition of a swivel extension to the base of the slit lamp allows the entire unit to slide between the arms of the wheelchair at a height that is comfortable for the patient.

Humans↗
PubMed1989

When does the failure to find a difference mean that there is none?

When a published clinical report concludes that there is no difference between two or more groups of patients, the reader must discern between two alternative possibilities. Either there is truly no difference in outcome between the groups or the study failed to detect an actual difference. The application of sample size and power calculations to outcome variables in a clinical study can provide essential insight into resolving this ambiguity. While one can never prove that there is no difference between groups of patients, these techniques can estimate the likelihood that a particular study will detect or fail to detect a difference of specified size.

Adrenergic beta-Antagonists↗
PubMed1989

Cost effectiveness of current approaches to the control of retinopathy in type I diabetics.

Diabetic retinopathy is a leading cause of blindness among working age Americans. The epidemiology of diabetic eye disease has been well described in population-based studies and the effects of laser treatment have been tested in randomized controlled trials. The authors have designed a computer simulation model using the published reports of these studies to predict the medical and economic effects of applying currently accepted methods for the control of diabetic retinopathy to the population of type I diabetics. Recommendations for screening are taken from the Public Health Committee of the American Academy of Ophthalmology. Treatment recommendations and treatment efficacy are drawn from the reports of the Diabetic Retinopathy Study (DRS) and the Early Treatment Diabetic Retinopathy Study (ETDRS). Costs of screening and treatment are drawn from published Medicare reimbursement data. Over a 60-year period, the model predicts that proliferative diabetic retinopathy (PDR) requiring panretinal photocoagulation (PRP) will eventually develop in 72% of type I diabetics and macular edema will develop in 42%. If these treatments are delivered as recommended in the clinical trials, the model predicts a cost of $966 per person-year of vision saved from proliferative retinopathy and $1118 per person-year of central acuity saved from macular edema. This is only one seventh of the $6900 average cost of 1 year of Social Security Disability for those disabled by vision loss. Therefore, this model supports the use of federally funded eye care to prevent blindness in medically uninsured diabetics.

Adolescent↗
PubMed1989

Laser sclerostomy ab interno using a continuous wave Nd:YAG laser.

We report the use of a continuous wave Nd:YAG (CW-YAG) laser focused through a sapphire crystal to create a filtering bleb by ab-interno sclerostomy. A 2-mm clear corneal incision was made in each eye of five anesthetized Dutch Belted rabbits, and the 30-mm-long sapphire crystal with a 0.2-mm focal tip was passed across the anterior chamber until it came in contact with the opposite angle. Between two and three pulses of 0.8 J were required to produce a filtering bleb in each of the 10 eyes. The overlying conjunctiva was not damaged; the procedure time was under five minutes. Histological examination revealed a surrounding area of scleral melting that extended an average of 0.06 mm from the sclerostomy. These data suggest that the CW-YAG laser may be useful in performing glaucoma filtering surgery with minimal damage to surrounding ocular tissues.

Animals↗
PubMed1987

Brain stem anesthesia after retrobulbar block.

Presented is a series of eight patients in whom neurologic sequelae developed after retrobulbar anesthesia. All patients demonstrated blockade of one or more cranial nerves and six progressed to apnea, requiring intubation and mechanical ventilation. Neurologic findings included amaurosis in the contralateral eye (5 patients), nonreactive pupil in the contralateral eye (6 patients), ductional defects (2 patients), and dysphagia (4 patients). In all cases, these findings resolved in 2 to 12 hours. In patients who progressed to apnea, spontaneous respiration resumed within 30 to 60 minutes. These findings are particularly significant in light of recent decisions to reduce anesthesia coverage for cataract surgery in some regions.

Adult↗
PubMedDate not supplied

Cataract and latitude.

For many years, it has been suggested that exposure to sunlight, particularly its ultraviolet component, may be associated with an increased risk of senile cataract. This paper addresses 1) the physical and geographic variables that affect the entry of ultraviolet light in the eye; 2) the epidemiologic evidence that associates cataract with ultraviolet light exposure; and 3) the effectiveness of personal barrier protection (i.e. sunglasses and hats) in reducing ocular exposure to ultraviolet light. The epidemiologic evidence is drawn from studies in Australia, China, Tibet, and the United States. The U.S. evidence consists of data from the Maryland Watermen study and analyses of cataract surgery under the Medicare program which provides health insurance for nearly all Americans age 65 and over (30 million) and pays for 85% of the 1.3 million cataract extractions performed annually in the U.S. Analysis of the Medicard data shown that, after controlling for age, sex, and race, and income of the population and also controlling for supply of ophthalmologists, optometrists, price of surgery and local practice costs, the strongest predictor of cataract surgery likelihood in a Medicare beneficiary is the person's latitude of residence. Latitude correlates directly with the UV-B content of sunlight, because the incident angle of the sun determines the atmospheric penetration of ultraviolet radiation. Data suggest that the probability of cataract surgery in the U.S. increases by 3% for each 1 degree decrease (i.e. more Southerly) in latitude.

Aged↗
PubMedDate not supplied

Preventing blindness in Americans: the need for eye health education.

Black Americans are twice as likely to be blind as their white counterparts. Although blindness is preventable or curable in half of the patients studied, we have found that black Americans are only half as likely to be treated for glaucoma or cataract, which are the two leading causes of blindness in this population. Our data show that this treatment gap is not related to the supply of ophthalmologists or the patients' personal income, even among insured populations. In addition to the devastating financial costs incurred by blind individuals and their families, a single year of blindness for a working age American costs the federal government approximately $12,000. Research has shown that preventing blindness is often less expensive, in simple economic terms, than paying for the costs a blind individual incurs. These findings raise important questions about access to care and how it may improve within the context of health care reform. Government surveys show that black Americans, even those with health insurance, are significantly less likely to seek or obtain examination by an ophthalmologist. In studying utilization of care, we found that, in aggregate, black Americans who see an ophthalmologist are as likely as their white counterparts to be treated for glaucoma, cataract, and other blinding diseases. We propose that, beyond universal access to health insurance, eye health education that influences people to see an ophthalmologist may be the single most important step we can take to prevent needless blindness. Not only can education and preventive eye care save needless suffering, it may save scarce federal dollars as well.

Blindness↗
PubMedDate not supplied

Preference values for visual states in patients planning to undergo cataract surgery.

To assess how preference values that cataract surgery patients assign to their preoperative visual states relate to visual acuity and problems in specific aspects of daily life, the authors interviewed 47 patients scheduled to have cataract surgery. Using a rating-scale technique with a scale from 0 (death) to 1 (excellent health), the patients had a mean preference value of 0.68 for their preoperative vision. Patients' preference values for their preoperative vision were more closely related to problems in specific aspects of daily life (especially feelings of depression and problems interacting with people) than to visual acuity in the operative eye, better eye, or worse eye, or a weighted average of visual acuities in both eyes. These results provide a rationale for relying more on patients' views about the effects of visual impairment than on measures of visual acuity when assessing the need for cataract surgery.

Activities of Daily Living↗
PubMedDate not supplied

Office visits to ophthalmologists and other physicians for eye care among the U.S. population, 1990.

Despite growth in the use of ophthalmologic care in the last decade, little is known about the use of eye care services and patterns of physician contact across population subgroups. As the U.S. population grows older, such information is crucial in planning strategies for treatment and prevention of eye disorders as well as in identifying potential problems in access and use of eye care. Using the 1990 National Ambulatory Medical Care Survey data, a descriptive statistical analysis was employed to profile the possible variations in eye care-related office visits to ophthalmologists and other physicians across demographic groups. In 1990, a total of 49.3 million visits that were related primarily to an ocular disorder were made to physicians' offices; 43.8 million (89 percent) of these were visits to ophthalmologists and 5.4 million (11 percent) to other physicians. Use of ambulatory eye care varied across demographic subgroups. Those ages 65 or older had a substantially higher rate of eye care related outpatient visits per 1,000 persons per year compared with the rest of the population (743.6 per 1,000 versus 118.5 per 1,000, P < 0.001). Women had a higher rate than men (216.0 per 1,000 versus 177.0 per 1,000, 0.01; P < 0.05). Blacks had a substantially lower rate than whites (143.2 per 1,000 versus 194.6 per 1,000, 0.001; P < 0.01). Those who visited ophthalmologists' offices also differed from those who visited other physicians' offices in terms of their age, sex, race, health insurance status, and disease characteristics. It is important to devote increased attention to the prevention of vision loss among the population groups that have a higher risk of developing eye diseases and that also may have underused or have less access to care. Results from this analysis, in combination with data on the prevalence of ocular disorders for different population groups, provide useful information to identify these high-risk groups.

Adolescent↗