Biomedical subjects
J C Huff
Publications and source records attributed to J C Huff.
Zinc correction of defective chemotaxis in acrodermatitis enteropathica.
Three patients with acrodermatitis enteropathica (AE), a disorder of zinc metabolism, demonstrated a zinc-responsive defect in chemotaxis of neutrophils and monocytes. Monocyte chemotaxis was depressed during a controlled period of zinc deficiency and increased to normal values after administration of oral zinc sulfate supplements that was sufficient to restore normal plasma zinc levels. In the only patient in whom neutrophils were also studied, a similar defect in chemotaxis of neutrophils was corrected by administration of zinc sulfate supplements. Preincubation of defective cells in vitro with zinc sulfate increased chemotaxis in an almost linear dose-response relationship. These findings suggest an important role for zinc in neutrophil and monocyte chemotaxis and demonstrate a correctable immune defect in AE.
Atopic dermatitis: etiology and pathogenesis.
Atopic dermatitis is a recognizable phenotype that most likely results from several mechanisms. An increasing number of children with atopic dermatitis are recognized as having immune defects, although the exact incidence of such immunodeficiency states among patients with atopic dermatitis is unknown. Children with atopic dermatitis who suffer recurrent or persistent infections should undergo immunologic evaluation. Ideally, this should include evaluation of cell-mediated immunity as well as neutrophil and monocyte chemotaxis. Further investigation into the beta-blockade theory may enhance our understanding of atopic dermatitis. Careful attention to factors exacerbating atopic dermatitis is essential in understanding this problem. Abnormal sweating, dry skin, sensitivity to contactants, and emotional stress should always be considered in evaluation of children with atopic dermatitis.
Hepatitis A and facilities for preschool children.
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Epidemic viral hepatitis, type B, in hospital personnel.
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An "outbreak" of juvenile diabetes mellitus: consideration of a viral etiology.
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Parenterally transmitted hepatitis A associated with platelet transfusions. Epidemiologic study of an outbreak in a marrow transplantation center.
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Letter: Hepatitis from clams.
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Misdiagnosis, treatments, and outcomes in the immunobullous diseases in children.
As a group, the immunobullous diseases are very uncommon in childhood. We analyzed all cases of immunobullous diseases in individuals under age 18 years which we had evaluated at the University of Colorado and examined their age of onset, diagnostic difficulties, treatments, and outcomes. This was considered to be a representative North American population within a single referral area which contained a diverse ethnic population mixture. Further, we believe this study to be uniquely uniform in that all the patients were examined by us using the same diagnostic strategy and the immunofluorescent (IF) diagnostic tests were performed by the same individual (J.C. Huff) using uniform diagnostic criteria and consistent IF techniques.