Stereospecificity of the in vitro and in vivo blockade of beta-receptors by FM 24, a slowly reversible ligand.
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Biomedical subjects
Publications and source records attributed to J C Hardy.
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Based on retrospective analysis of 430 cases of retroperitoneal fibrosis, a classification into various etiological groups and an evaluation of the best diagnostic approach and treatment was possible. In patients presenting moderate upper urinary dilation corticosteroids alone proved to be of value in 93% of cases. Azathioprin given in combination with corticosteroids seems to be effective. The surgical 'therapy of choice' was ureterolysis with an effective intraperitoneal transposition. Ureteral restenosis after this procedure (in 22%) occurred mainly when it was not combined with long-term corticosteroid therapy. When the lower half of the ureter is involved we favor ureterolysis, its prevesical section, complete intraperitoneal transposition and a primary psoas-hitch bladder flap.
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It appears that the palatal lift prosthesis is an effective prosthesis to improve palatopharyngeal incompetence in selected patients. Despite the inconvenience and problems associated with a prosthesis, this procedure is indicated for selected patients who have anatomically normal palates that are dysfunctional. The ultimate benefit of the palatal lift prostheses to the speech of the patients is not the subject of this report. However, it should be noted that many patients can benefit from speech therapy after a satisfactory prosthetic result has been achieved.
To determine the effects of arranging test tasks by order of difficulty, two test forms were administered to each of 20 patients with aphasia. The two test forms were split halves of the Porch Index of Communicative Ability. One of the test forms, Form EH, was presented to each patient with the subtests arranged for the individual subject in an order from easy to hard. The other test form, Form HE, was administered to each subject in the hard-to-easy order. There was no significant difference between the performance of the subjects on the Form EH and their performance on Form HE.
This study determined whether children could learn to replicate four positions of lingual-palatal contact with and without topical anesthesia that eliminated touch-pressure sensations. First-grade boys, nine with good articulation skills and nine with poor articulation skills, were used as subjects. Results suggest that individuals are able to learn nonspeech tasks of tongue positioning by relying on muscle spindles or deep receptors within the tongue, or both, or by relying on lingual touch-pressure or other surface receptors within the tongue, or, by a combination of deep and surface receptors of the tongue. Further, tongue positioning need not be dependent on touch-pressure or superficial tactile mechanisms. Children with relatively severe articulation problems performed more poorly on the tasks of precise tongue placement than children with good articulation skills. And finally, children with relatively severe articulation problems may be able to improve their initially poor performance on tongue placement tasks with specific training on those tasks, implying that this group did receive the intraoral sensory feedback necessary to learn the task, but that more experience was needed for the learning to occur.
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