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Biomedical subjects

J C Hadley

Publications and source records attributed to J C Hadley.

17 recordsLinked to original sources
PubMed1999

I can't!

As perianesthesia nurses, we are familiar with patient anxiety levels. Patients make their nurses especially aware of presurgical anxiety and patient assessments are made considering the very real effects of such apprehension. However, in our own lives, we may be less enlightened about fear and anxiety. This article, melding the approaches suggested in both popular and scientific literature, addresses the issue of recognizing personal fears and developing an action plan to turn fears into successes.

Anxiety↗
PubMed1998

Glycation changes the charge distribution of type I collagen fibrils.

In aging and diabetes, glycation of collagen molecules leads to the formation of cross-links that could alter the surface charge on collagen fibrils, and hence affect the properties and correct functioning of a number of tissues. The electron-optical stain phosphotungstic acid (PTA) binds to positively charged amino acid side-chains and leads to the characteristic banding pattern of collagen seen in the electron microscope; any change in the charge on these side-chains brought about by glycation will affect the uptake of PTA. We found that, upon glycation, a decrease in stain uptake was observed at up to five regions along the collagen D-period; the greatest decrease in stain uptake was apparent at the c1 band. This reduction in PTA uptake indicates that the binding of fructose leads to an alteration in the surface charge at several sites along the D-period. Not all lysine and arginine residues are involved; there appear to be specific residues that suffer a loss of positive charge.

Age Factors↗
PubMed1992

In a small way.

Explore the source record for details and available documents.

Delivery of Health Care↗
PubMed1990

Something for pain: new trends in epidural analgesia.

Epidural infusion and combined drug therapy have an important place in the control of severe pain. With the development of new methods of using these drugs, PACU practitioner's responsibilities extent in yet another direction. PACU nurses must be knowledgeable about the drugs used, the methods by which they are administered, and their side effects. General care of the patient with intermittent and continuous epidural infusion and the use of combined drug therapy is reviewed.

Analgesia, Epidural↗
PubMed1978

Steroidal control of the release of the preovulatory surge of luteinizing hormone in the rat.

Experiments were carried out on 4 day cyclic rats or immature rats induced to ovulate by administration of pregnant mare serum gonadotrophin. Removal of the ovaries and adrenal glands at 17.00 h of pro-oestrus, i.e. after the critical period, prevented the appearance of the surge of LH. Sham-operation or removal of only one of the sets of glands had no effect. This indicates that the preovulatory increase in the concentration of oestradiol is not solely responsible for the surge of LH; the presence of a steroid, secreted by the ovaries and adrenal glands in the late afternoon of pro-oestrus, is also required. Attempts were made to reinstate the surge of LH in ovariectomized, adrenalectomized rats by administration of one of the steroids normally secreted in late pro-oestrus. Corticosterone, 20alpha- and 20beta-hydroxy-4-pregnen-3-one and 17alpha-hydroxyprogesterone all had no effect. Progesterone injected at the time of the operation stimulated the release of LH but only after the plasma concentration had reached its maximum 3--5 hr after injection. Testosterone also stimulated the release of LH some hours after administration.

Adrenalectomy↗
PubMed1975

Unconjugated oestrogen and progesterone concentrations in the blood of bitches with false pregnancy and pyometra.

The changes in total unconjugated oestrogen and progesterone concentrations in the peripheral blood of one bitch throughout a false pregnancy were measured. The levels of these hormones detected in 11 bitches when examined during a false pregnancy, and in 13 other bitches with pyometa are also reported. Oestrogen and progesterone concentrations were within normal limits in both of these conditions where single samples were obtained, but the bitch with false pregnancy studied in detail showed a raised oestrogen level during metoestrus. The significance of these results is discussed in relation to previous studies on the aetiology of false pregnancy and pyometra.

Animals↗
PubMed1975

Total unconjugated oestrogen and progesterone concentrations in peripheral blood during the oestrous cycle of the dog.

From the beginning of pro-oestrus to the end of metoestrus, daily peripheral blood samples were withdrawn from six bitches. Further samples were obtained during anoestrus. Oestrogen values rose from the onset of pro-oestrus to attain a peak value of 25-3 +/- 4-8 pg/ml on Day 1 of oestrus. Progesterone concentrations began to rise 2 days before the oestrogen peak, and reached their highest levels of 18-9 +/- 1-0 ng/ml 16 days after the end of oestrus. After oestrus, an oestrogen rise was detected which reached a peak at Day 18 of metoestrus. The duration of oestrus was unrelated to the length of time that oestrogen levels were raised, or the maximum values were attained. No significant oestrogen levels were detected during anoestrus.

Animals↗
PubMed1975

Total unconjugated oestrogen and progesterone concentrations in peripheral blood during pregnancy in the dog.

Daily blood samples were withdrawn from three bitches throughout gestation and at intervals during parturition. The highest mean oestrogen value of 26-1 +/- 6-0 pg/ml was detected on the last day of pro-oestrus, and a lower post-oestrous peak occurred shortly after the maximum progesterone value of 17-0 +/- 1-0 ng/ml which was recorded 18 days after first service. No oestrogen rise was detected before parturition, and progesterone could not be detected after the end of parturition.

Animals↗