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Biomedical subjects

J C Hache

Publications and source records attributed to J C Hache.

At least 55 records · Page 3Linked to original sources
PubMed1989

X-shaped macular dystrophy with flavimaculatus flecks.

Two families showed a retinal pigment epithelial dystrophy characterized by an X-shaped yellowish macular lesion and numerous flavimaculatus retinal flecks. Nine members were variously affected. The condition was bilateral, had a dominant inheritance and started in middle age with a slow-developing macular lesion. Visual functions were often minimally disturbed for 2 or 3 decades. The flavimaculatus flecks which differed in number appeared only as secondary phenomena yet increased in number and size. At the onset of the disease, the ERG and EOG as well as colour vision were normal and became altered only in the course of a very slow process.

Adult↗
PubMed1989

[Blindness following orbital reconstruction].

A 20 year old patient who suffered from contusion of the optic nerve due to a complex craniofacial fracture, developed, after orbital reconstruction for sequelae of the fracture, loss of light perception which was transiently improved by drug treatment. The clinical and electrophysiological course suggest the presence of ischaemic optic neuropathy.

Adult↗
PubMed1989

[Jaffe's syndrome and anomalies of capillary permeability].

The parallelism between ophthalmoscopy and angiography in the different grade classifications of idiopathic epiretinal membranes is not compulsory: spotty and irregular fluorescein leakage is apparent in many cases, even early. This leakage, who might bring biochemical factors stimulating cellular migration and proliferation could therefore be usually associated with more progression of the membrane.

Adult↗
PubMed1989

[Asymmetry of visual perceptive activity of faces and emotional facial expressions].

Eye movements were studied in 40 right-handed subjects during perception of symmetrical chimerical faces. These movements were recorded using an original system based on a differential optical method for the detection of corneal reflection and of the pupil made shiny. Under basal conditions, the first fixation was usually located in the left visual hemifield. The subjects spent more time gazing at the right hemiface (P less than 0.04). This visuo-spatial asymmetry in favour of the left hemispace was increased when the subject was requested to determine the emotional expressions of a new series of faces (P less than 0.002). Compared with basal conditions, the increase in the percentage of time spent in the left area was significant (P less than 0.035). An analysis performed on the first 3 seconds confirmed and amplified the differences observed. These results can partly be explained by reading habits and exploratory activity for symmetrical shapes. However, activation of the right hemisphere, specialized in the perception of faces and facial expressions, probably influenced visual exploration by drawing attention to the left area and favouring the left visual hemifield.

Adult↗
PubMed1987

Lateral gaze disturbance in a case of Wallenberg's syndrome.

A 63-year-old Caucasian man was admitted for Wallenberg's syndrome following a left vertebral artery thrombosis. In addition to the classical symptoms, an axial lateropulsion to the left and ocular motor disorders (vertical diplopia, tonic deviation of the gaze to the left, skew deviation and horizonto-rotatory nystagmus) were present. These clinical signs are unusual, but in common Wallenberg's syndrome, neurophysiological tests often reveal slight abnormalities of oculomotor function: impairment of jerks, skew deviation, lateral deviation of the gaze in darkness. Interruption of cerebellar pathways is thought to be the cause of these symptoms. Their existence does not seem to change the outcome of these cases.

Eye Movements↗
PubMed1987

[Devic's optic neuromyelitis. 4 cases].

We report 4 cases of neuromyelitis optic (Devic's disease), with 3 to 7 year-follow-up for 3 of them. Most of the data agreed with the previously reported cases: subacute onset, association of optic neuritis and myelitis within several weeks or months, absence of relapse, good prognosis for paraplegia but poor prognosis for visual loss, and effectiveness of corticosteroids on spinal cord involvement in 4 cases. Moreover these 4 cases have revealed the following rare features: unilateral visual disturbance (1 case), total recovery of visual signs (1 case) with only a short period of follow-up, onset during childhood (1 case), onset following an acute lymphocytic meningitis (1 case), and dependency from corticosteroid therapy (2 cases). None of the patients had obvious immunological disturbance. N.M.R. imaging revealed in 2 cases, disseminated demyelinated areas which confirmed neuropathological data from the literature, showing that anatomical lesions could be wider than expected on clinical signs. The poor visual prognosis, the serum inflammatory signs, the epidemiologic data, the high cell and protein levels in C.S.F., and the absence of relapse suggested, in our cases and in most of the previously reported ones, that neuromyelitis optic must be differentiated from multiple sclerosis.

Adrenal Cortex Hormones↗
PubMed1987

[Visual evoked potentials in glaucoma and ocular hypertension].

In 60 patients affected by primary open angle glaucoma, in 30 patients with isolated ocular hypertension and in 30 healthy patients visual evoked potentials were studied. Amplitudes and latencies of P100 of the pattern reversal visually evoked potential were recorded and compared between the three groups. A new method is presented. A significant increase in VEP latency could only be demonstrated in the pathological groups. The reasons of these findings are discussed.

Age Factors↗