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Biomedical subjects

J C Gough

Publications and source records attributed to J C Gough.

8 recordsLinked to original sources

Angiomyolipoma with lymph node involvement.

A renal mass accompanied by adenopathy was found incidentally in an asymptomatic 25-year-old woman. The computed tomography and ultrasonography findings suggested a malignant neoplasm. At pathological examination, however, renal angiomyolipoma was diagnosed; the lesion contained almost no fat and involved the lymph nodes, an unusual presentation for this tumour.

Adult

Inflammatory pseudotumor of the spleen. Morphological, radiological, immunophenotypic, and ultrastructural features.

A case of inflammatory pseudotumor of the spleen is described. Its rapid enlargement, demonstrable by ultrasound studies and computed tomographic scan, its gross appearance, and some of its histologic features suggested malignant lymphoma. However, a characteristic circumferential zonal pattern and polytypic immunophenotype helped to establish the correct diagnosis. In retrospect, the zonal pattern was also identified radiologically.

Adult

Melanocyte colonization of nodal metastasis from oral carcinoma.

Melanocyte colonization of metastases in cervical lymph nodes is described. The tumor was a squamous carcinoma of the floor of the mouth, metastasizing to cervical lymph nodes. The melanocytes were easily visible on sections of the nodes stained with hematoxylin and eosin and were confirmed by Masson-Fontana staining. Multiple sections through the oral primary tumor failed to show melanocyte colonization of the tumor. This is the second report of this phenomenon and represents only the third known case of this entity.

Carcinoma, Squamous Cell

Primary sarcoma of the heart: a light and electron microscopic study of two cases.

Two cases of primary malignant cardiac neoplasms are presented. The first, an angiosarcoma of the right atrium, developed in a 44-year-old housewife, who survived 23 days from the time of presentation; diagnosis was made at necropsy. The second, an embryonal rhabdomyosarcoma of the right ventricle, developed in a 17-year-old student; diagnosis was made by angiocardiography. He underwent surgery and cytotoxic and irradiation therapy and died 14 months later.

Adolescent

Fine needle aspiration biopsy diagnosis of a gastrointestinal stromal tumor utilizing transmission electron microscopy.

BACKGROUND: Gastrointestinal stromal tumors are spindle cell tumors with no specific cell lineage occurring in the gastrointestinal tract and cytologically resemble other benign and malignant spindle cell tumors. Distinctive ultrastructural features in some of these tumors have not been previously emphasized. CASE: A 76-year-old, white female presented with multiple tumor masses distributed in the large bowel. Fine needle aspiration biopsy demonstrated a cellular aspirate composed of spindle cells, some of which were loosely arrayed and some of which were in cohesive clusters. Many of the cells contained long cytoplasmic processes. Ultrastructurally the cells demonstrated long cytoplasmic processes upon which multiple shorter, fingerlike projections arose. Subsequent surgical resection confirmed the cytologic and ultrastructural findings. CONCLUSION: Electron microscopy has a role to play in the diagnosis of gastrointestinal stromal tumors.

Aged