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Biomedical subjects

J C Gillin

Publications and source records attributed to J C Gillin.

At least 307 records · Page 17Linked to original sources
PubMed1977

Physostigmine analgesia and somatosensory evoked responses in man.

14 normal volunteers were given 0.5 mg physostigmine or saline placebo i.v. in a randomized double blind trial. Subjects were pretreated with 0.5 mg methscopolamine i.m. on both days. Pain ratings and average evoked responses were obtained to brief electrical stimuli administered to the forearm. Pain response criterion was significantly higher on physostigmine than on placebo. Average evoked response component P100 was significantly smaller on physostigmine than placebo, especially for higher intensity stimuli. These results are consistent with central cholinergic modulation of pain and arousal systems in man.

Adult↗
PubMed1977

Alterations in motor activity, sleep, and biochemistry in a cycling manic-depressive patient.

Biochemical and electrophysiological factors were studied longitudinally in a rapidly cycling manic-depressive patient. Slow changes in mood, motor activity, sleep, and urinary norepinephrine levels during the course of each depressed and manic episode are reported, as well as rapid alterations in many variables at the time of mood switch. Urinary concentrations of norepinephrine and its metabolite, 3-methoxy-4-hydroxyphenyl glycol (MHPG) were significantly lower in depression than in mania; norepinephrine but not MHPG excretion increased prior to the switch. We postulate that the slow behavioral and biological changes preceding switches in this patient are an important manifestation of the cyclic process in manic-depressive illness.

Adult↗
PubMed1977

A method for sleep depriving rats.

A method is described for sleep depriving up to 12 rats at a time by placing them in two large rotating cylinders. EEG data, previously unavailable for rats treated in this manner, show that total sleep time was significantly reduced from 47.0% to 3.8% of a 24-hr period. There was no selective reduction of REM or non-REM sleep.

Animals↗
PubMed1977

An EEG sleep study of a bipolar (manic-depressive) patient with a nocturnal switch process.

Fifty-eight all-night polygraphic sleep recordings were obtained on an unmedicated female bioplar (manic-depressive) patient who switched into and out of mania eight times. While depressed she was hypersomniac and exhibited elevated Rapid Eye Movement (REM) sleep time and short REM latency. On four nights, she apparently switched into mania while asleep. The last recorded sleep stage in each case was REM sleep.

Adult↗
PubMed1977

Dose response and time course effects of N,N-dimethyltryptamine on disruption of rat shuttlebox avoidance.

N,N-Dimethyltryptamine (DMT) was given (ip) in different doses (0.25, 0.5, 1.0, 2.0, 4.0, 8.0 mg/kg) in a randomized order to a group of ten rats (Fisher 344/Mai) who were trained to a high, stable base line of conditioned avoidance responding in the shuttlebox. DMT produced dose-dependent disruptive effects, as a sigmoid function, with 1.0 mg/kg the minimal dose causing disruption and progressively more disruption with increasing doses, reaching a plateau at the highest dose. The disruptive effects were time-related, with onset and peak 8 min after injection, gradual decline thereafter, and disappearance by about 25-30 min. Both the threshold dose and time course for the disruptive effects correspond closely to what has been previously reported for DMT's psychological effects in humans.

Animals↗
PubMed1977

CPK: relationship of psychological and physical stress.

In the past few years, the finding of elevated serum levels of creatine phosphokinase in some acutely psychotic patients has commanded a great deal of interest. Although structural abnormalities in nerve and muscle of some of these patients have been described, the cause remains obscure. Physical stress will raise CPK, but the role of psychological stress has been unclear. CPK levels of medical students were measured before and after an academic examination, but no relationship between examination stress and changes in CPK was found. A significantly higher number of CPK elevations were reported in association with vigorous exercise. These findings are consistent with a hypothesis that psychological stress plays an insignificant role in the CPK elevations seen in some acutely psychotic patients. The importance of physical activity in elevated CPK values was reconfirmed.

Adult↗