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Biomedical subjects

J C Gabilan

Publications and source records attributed to J C Gabilan.

64 records · Page 4Linked to original sources
PubMedDate not supplied

[Comparison between the number and nature of fecal clostridia and other risk factors implicated in the intestinal pathology of newborn infants].

One-hundred and fifteen infants aged 1 to 31 days from two intensive-care units were grouped into 6 classes according to clinical criteria (enterocolitis with or without anatomopathological examination and pneumatosis intestinalis, "haemorrhagic colitis", acute diarrhoea or absence of intestinal disorders). The total number of viable bacteria, the number of Clostridium and, in some cases, the presence of rota- and/or coronavirus were determined in their stools. The incidence of Clostridium in the stools of infants with enterocolitis (with or without pneumatosis intestinalis) or haemorrhagic colitis was not significantly different from that of infants without intestinal disorders, whereas stools of infants with acute diarrhoea less often contained Clostridium than those of other infants. C. butyricum, C. difficile, C. perfringens, C. tertium, and C. sordellii were identified. Correspondence analysis comparing the variable, "clinical profile", with 23 other variables, suggested that the variables of gemellity, a birthweight below 1900 g, a gestational age of less than 35 weeks, respiratory distress, umbilical catheterization and a Clostridium count above 10(7)/g at the onset of clinical signs, i.e. between 8 to 12 days of age, were linked to the clinical profile of necrotizing enterocolitis with pneumatosis intestinalis. Conversely, the absence of gemellity, a high birthweight and gestational age, the absence of respiratory distress or umbilical catheterization, the onset of diarrhoea within 8 days, and the presence of rota- and/or coronavirus in the stools were linked with a clinical profile of acute diarrhoea.

Birth Weight↗
PubMedDate not supplied

[Effect of orally administered bovine lactoferrin and bovine IgG on the establishment of Escherichia coli in the digestive tract of gnotobiotic mice and human newborn infants].

The bacteriostatic effect of the association bovine lactoferrin (LF) and bovine IgG (IgG) was studied in vitro and in vivo against two Escherichia coli strains, S17 and EMO1, isolated from the faecal flora of mouse and man, respectively. These two strains were sensitive in vitro to the bacteriostatic effect of LF + IgG. A kinetic study of the in vivo establishment of E. coli S17 was followed in axenic mice associated with that strain. Seven hours after inoculation, no difference was observed in the faecal level of E. coli between control mice and mice fed the same diet supplemented with LF + IgG. An in vivo study was also carried out in human newborns receiving either maternized milk (Nursie) or the same milk supplemented with LF + IgG during the first 48 h of life. One group of babies was inoculated at birth with E. coli EMO1, while another was not. Between the ages of 1 and 5 days, the kinetics of establishment of the E. coli strains spontaneously found in the digestive tract of non-inoculated babies was not significantly different between the group which received milk supplemented with LF + IgG and that which did not. This result was confirmed in infants inoculated with E. coli EMO1. Likewise, the faecal levels of E. coli EMO1 were similar in the supplemented and non-supplemented babies, and, already from day 1, the population level was high and only slight individual variations between babies of the same group were observed. These findings show that the in vitro bacteriostatic effect of LF + IgG on the growth of E. coli strains is not found in vivo.

Animals↗
PubMedDate not supplied

[Implantation of a strain of "Escherichia coli" in the digestive tract of human new-borns: barrier effect against antibioresistant "E. coli" (author's transl)].

Twenty-two healthy human new-borns were inoculated within two hours of birth with a strain of Escherichia coli. This strain was isolated from the faecal flora of an healthy adult and was plasmid-free, nontoxigenic in vitro or in vivo, and sensitive to all usual antibiotics. This strain became established at a high population level within two days in all new-borns and remained at a very high level during the following days in almost all cases (86%). Strains of E. coli resistant to ampicillin or tetracycline were found in 6 of 22 inoculated infants as well as in 7 of the 24 control infants. These resistant strains remained at a very high level in the control infants but disappeared, or decreased to a subdominant level, in the inoculated infants. These results show that a totally innocuous strain of E. coli can exert in holoxenic conditions a barrier effect on antibiotic resistant E. coli strains. They also suggest the interest of inoculating such a strain at birth in order to prevent proliferation of potentially pathogenic bacteria.

Adult↗
PubMedDate not supplied

[Bilateral pulmonary hypoplasia in neonates: a clinical and pathological review apropos of 17 cases].

17 neonates presenting with bilateral hypoplasia of the lungs are reported. Histologic examination of the 13 neonates who died before the 24th hour of life showed 2 histologic types: a "fetal" type, similar to the pulmonary histology of 16-20 weeks fetuses, and a "miniature" type, with reduced dimensions, of harmonious aspect. The association of pulmonary hypoplasia with other fetal malformations suggests a different pathophysiologic mechanism for each type. Recovery may be possible in children with the "miniature" type.

Abnormalities, Multiple↗