Biomedical subjects

J C Fouron

Publications and source records attributed to J C Fouron.

At least 127 records · Page 7Linked to original sources

PubMed1976

The adaptation of the fetal red cells of newborn lambs to extrauterine life: the role of 2,3-diphosphoglycerate and and adult hemoglobin.

The purpose of this study was to determine the interrelationship of the rise and fall of 2,3-diphosphoglycerate (DPG) with the increase in adult hemoglobin and the decrease in red cell oxygen hemoglobin affinity after birth in normal lambs. It was found that the mean maximum DPG level was 26.71 +/- 4.98 mol/g Hb at 7.5 +/- 1.1 days. At the same time the mean P50 and adult hemoglobin level was 27.0 +/- 1.4 mm Hg and 31.1 +/- 11.i%, respectively. In the individual lambs, the level of their maximum DPG correlated inversely with the amount of adult hemoglobin (r-0.77, P less than 0.05). Once the DPG began to decrease, there was an inverse correlation between the DPG and the adult hemoglobin present in the red cell (r = 0.68, P less than 0.001). It appeared that the rise in DPG postanatally is only a compensatory mechanism until an adequate amount of adult hemoglobin is present. This fact was borne out by the second part of the study in which exchange transfusions with adult red cells were performed on five newborn lambs during the first 24 hr after birth and aborted the rise in DPG.

Adaptation, Physiological↗

PubMed1975

Cardiovascular changes associated with fetal breathing.

Studies were carried out on seven fetal lambs, 3 to 1 weeks prior to the expected date of delivery to determine if, during fetal breathing, cardiovascular events were similar to those described as occurring with respiration after birth. The following changes were observed; (1) a slight decrease in pressures with the initiation of the rapid inspiratory movements followed by: (2) a marked elevation of the systolic and diastolic pressures; (3) a cyclic variation characterized by a fall in arterial pressure with inspiration; (4) a variable acceleration of the heart rate; and finally, (5) a typical respiratory arrhythmia. These findings demonstrated that, during fetal respiratory movements, there are some cardiovascular changes which are specific to this period of life. There are other changes which are identical to what has been observed after birth. These latter cardiovascular changes imply that the endotracheal pressure variations are the reflection of authentic inspiratory movements under the influence of the central nervous system.

Animals↗

PubMed1975

[Heart tumors in children. Report of 3 cases with favorable spontaneous courses].

During a 14-year period, 8 cases of primary heart tumours were observed at Sainte-Justine Hospital. Three of these patients had a favourable course without any surgical treatment. The age of these patients was respectively 3 days, 7 weeks and 6 1/2 years. In what concerns the first two patients, the clinical and paraclinical pictures were suggestive of heart disease from the onset. Catheterization and angiocardiography confirmed the presence of a tumour deforming both ventricular cavities. In these two cases, an attempt at surgical resection proved to be impossible in view of the extent of the lesion. Biopsy demonstrated a rhabdomyoma in one of the patients and a diffuse fibroma in the other. Six and four years later, the patients were still alive, and an improvement of both the electrocardiogram and of the cardio-pulmonary X-ray pictures were noted. A second cardiac catheterization showed an almost complete disappearance of the pathological pictures. In what concerns the third patient, he was a 6-year old child with a classical Bourneville's tuberous sclerosis with a localized tumour at the junction of the superior vena cava and the right atrium. Three years later a control catheterization showed the tumour to have remained unchanged. Two conclusions might be drawn from these cases: 1 a surgical operation, although always indicated, should never entail a desperate attempt at tumour removal; 2 the prognosis should never be considered as lethal from the start.

Child, Preschool↗

PubMed1975

[Abnormalities of the aortic arch. Apropos of 30 surgical cases in children].

Few large surgical series have till now been devoted to aortic arch anomalies. Thirty cases operated upon in 10 years at the Hôpital Sainte-Justine are studied in the present work; they include: 8 cases of double-arch, 21 of aberrant subclavian arteries and 1 of aberrant brachio-cephalic trunk. In this apparently very complex embryological domain, a simplified classification, easy to remember even by the non-specialist, might be applied. There are no clinically significant differences between the various anatomical anomalies considered, the latter showing generally, soon after birth, by respiratory manifestations. The frequently severe spontaneous course requires an early diagnosis which relies on a simple procedure: the oesophagogram. A quick surgical treatment is then indicated, and the majority of our patients were operated upon in the early months of life. No post-operative death was observed and the long-term course might be considered as excellent in all the cases in which the malformation was alone and corrected early.

Aorta↗

PubMed1974