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Biomedical subjects

J C Emperaire

Publications and source records attributed to J C Emperaire.

At least 37 records · Page 2Linked to original sources
PubMed1989

[Male infertility and intrauterine insemination with abnormal sperm].

Intra-uterine insemination of capacitated sperm has disappointing results when this sperm is abnormal, since the overall pregnancy rate does not exceed 11 p. cent of the couples who have not given up before the 6th cycle of treatment. However, considering the ineffectiveness of the treatments of idiopathic or secondary oligo-astheno-teratospermia, and the still limited effectiveness of fertilization in vitro with his type of sperm, intra-uterine CAI may currently be offered for a limited time to sterile couples with very abnormal sperm, contingent on a precise methodology in the preparation of the sperm as well as the time of ovulation.

Female↗
PubMed1988

[Intra-uterine insemination with activated sperm. Results of conception compared in the various types of infertility in spouses].

A total of 180 infertile couples were treated with intra-uterine insemination of homologous capacitated sperm. The fertility disorder was: a cervical factor in 80 couples (44.4%), a male factor in 68 others (37.8%) and unexplained infertility in 32 couples (17.8%). All the patients received ovarian stimulation with HMG, and with ultrasonographic monitoring. Insemination was performed when the diameter of the dominant follicle reached 18 mm, and HCG 5,000 UI was given on the same day; another insemination was performed 40 hours later if the dominant follicle was still present. The 0.5 ml insemination sample was prepared through a migration-capacitation procedure into Earles medium which yielded 15% of the total motile spermatozoa in the ejaculate. A total of 22 pregnancies were recorded (12% of the couples) in 659 therapeutic cycles; the results however differed according to the infertility disorder: 18.8% of pregnancies in the cervical factor group, 15.6% in the unexplained infertility group and 2.9% only in the male factor group. The lowest number of inseminated motile spermatozoa for pregnancy to occur was 0.4 million. A mild hyperstimulation syndrome was noted in 28 cycles (3.1%); no complications of infectious or immunologic origin occurred. It appears that a procedure which results in a satisfactory pregnancy rate when the sperm is normal (cervical or unexplained infertility) yields poor conceptional results when the semen is abnormal. In cases where the male factor is predominant, intra-uterine insemination should not be performed in the periovulatory period but at ovulation time, and therefore requires either an accurate detection of the LH peak or complete hormonal and sonographic assessment in a stimulated cycle.

Chorionic Gonadotropin↗
PubMed1987

[Contribution of human menopausal gonadotropins purified as to their FSH content in anovulatory sterility presenting a difficult treatment problem].

A preparation of HMG purified to contain only FSH (FSH 75 IU/LH less than 1 IU) was used in 26 patients who had anovulatory sterility because of sclero-polycystic ovaries. It was a selected population in that all the patients had proved to be resistant to Clomiphene Citrate and at risk with HMG therapy. Purified urinary FSH was used and monitored as classical HMG treatment. 44 treatment cycles resulted in 33 ovulatory cycles (75%) and 6 pregnancies (13.6% per cycle). The number of cases of hyperstimulation (13.6%) was low when it is compared to situations at risk when HCG was administered in 2/3 of the treatment cycles. The results obtained in a population with a bad prognosis can be considered to be very encouraging and gives purified urinary FSH a specific place in our therapeutic armamentarium.

Adult↗
PubMed1982

Female fertility and donor insemination.

Artificial insemination with donor semen (AID) frozen in 0.25-ml straws yielded an overall pregnancy rate of 64% in a series of 131 patients. The pregnancy rate was significantly higher in patients whose husbands were azoospermic (70%) than in women whose husbands were severely subfertile (48.8%) (P less than 0.02). Equivalent ages of patients as well as donor distribution between both groups were confirmed. This study brings evidence that patients turning to AID because of severe male subfertility represent a selected hypofertile population, from which the highly fertile females have disappeared through previous spontaneous conception.

Female↗
PubMed1981

[Artificial insemination donor and female fertility (author's transl)].

The authors have reviewed 140 cases of AID using frozen sperm in fine straws. With a follow-up of one year from the date the last couple was brought into the survey, the crude percentage for conception is 65 and can reach up to 73.3% with a mean rate of conception per cycle of 10% in couples who carry on for a minimum of six cycles. The ability of the sperm to fertilise seems comparable whether they come from one or other of two centres for the study and storage of human sperm. The level for conception is less affected by features such as whether the sperm is fresh or frozen, or the number of spermatozoa that have been inseminated, than by the patient's age and also her fertility, in which also psycho-emotional factors have to be taken into account, but these are difficult to qualify. When the causes of lowered female fertility are able to be pinpointed and are curable, the hope for a successful pregnancy from AID should approach that found in so-called normal patients.

Abortion, Spontaneous↗
PubMed1979

Clomiphene test and clomiphene therapy in idiopathic male infertility.

Clomiphene citrate, 50 mg/day, was administered to 105 patients with idiopathic azoospermia or oligoasthenospermia. Plasma FSH, LH, testosterone, and in a few cases estradiol were evaluated on day 0 and day 15 of therapy. Twelve other patients with no treatment were assayed in the same way. Statistical analysis demonstrated that, as a group, the infertile male population responds normally to clomiphene administration. On the other hand, three types of individual responses were recorded: complete positive response, dissociated positive response, and negative response. Sixty-nine patients were randomly selected for clomiphene therapy, 50 mg/day for 100 days; however, of 54 who completed the treatment schedule, only 11 showed elevated sperm counts. A study of correlations between hormonal and semen responses to clomiphene indicates that a complete or dissociated endocrine response is not an accurate predictor of possible semen amelioration on long-term therapy; on the other hand, sperm characteristics did not improve in those patients who did not demonstrate a positive hormonal response, mainly testosterone, on the 15th day of therapy.

Adult↗
PubMed1979

Endometriosis and infertility. A review of sixty-two patients with danazol.

The authors present a clinical study of 62 infertile patients with endometriotic lesions diagnosed in all cases by laparoscopy. The large variety of lesions and the high incidence in this series of tumorous or tubal lesions, led in 39 cases to a combination of medical treatment with danazol with surgical intervention, i.e. excision or conservative surgery. The overall pregnancy rate was 46.7%, which proves the high efficacy of danazol in this situation.

Adult↗