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Biomedical subjects

J C Crawley

Publications and source records attributed to J C Crawley.

50 records · Page 3Linked to original sources
PubMed1975

Yttrium 90 in persistent synovitis of the knee - a single centre comparison. The retention and extra-articular spread of four 90-U radiocolloids.

The characteristics of three colloidal preparations of 90-Y currently used for the irradiation of chronic synovitis of the knee have been studied. One, 99-Y silicate, showed less leakage away from the joint than the other two preparations, 90-Y ferric hydroxide and 90-Y citrate. Comparable amounts of 90-Y were taken up regional lymph nodes when the silicate and ferric hydroxide forms were used; the greatest irradiation of regional lymph-nodes occured using the citrate form. In this respect all three preparations are inferior to the previously used preparation 90-Y resin colloid which is no longer manufactured.

Chronic Disease↗
PubMed1975

Myocardial blood flow following saphenous vein bypass surgery.

Myocardial blood flow was measured by the 133Xe clearance technique in 21 patients 6 to 31 months after saphenous vein grafting for coronary arterial disease. Preoperative measurements were made in 16. All patients had improved symptomatically, and 20 had returned to work. Thirty of 39 grafts were entered and selective injections of 133Xe performed. Flow in the left coronary artery (LCA) was unchanged postoperatively in 9, increased in 5, and decreased in 1 (preoperative mean = 54 ml/100 g/min, SD +/- 16; postoperative mean = 65 ml/100 g/min, SD +/- 20). Flow in the right coronary artery (RCA) was unchanged postoperatively in 3, decreased in 9, and increased in 2 (preoperative mean = 46 ml/100 g/min, SD +/- 18; postoperative mean = 33 ml/100 g/min, SD +/- 12). Nine of 14 grafts to the left anterior descending coronary artery showed flow rates significantly greater than those in the corresponding LCA. Two of the 3 circumflex grafts showed flow rates significantly lower than those in the LCA. Four of 8 right grafts showed significantly higher flow rates than those in the corresponding RCA. These findings correlated well with the angiographic appearances. We conclude that saphenous vein grafting increases total myocardial blood flow. The data suggest that the coronary arteries and the grafts are supplying different regions of the myocardium, and that the graft regions were previously underperfused. There would appear to be little mixing of blood between artery and graft regions.

Coronary Artery Bypass↗
PubMedDate not supplied

The effect of plasma free fatty acids and long-chain triglycerides on glucose metabolism in uncomplicated falciparum malaria.

To investigate the therapeutic potential of increased plasma free fatty acid (FFA) and triglyceride concentrations in hypoglycaemic patients receiving quinine, 32 untreated Thai adults with uncomplicated falciparum malaria were allocated at random to one of 4 regimens: 2 mg/kg/min dextrose infused over 60 min either alone (group A) or with a prior injection of 5000 units of heparin and simultaneous Intralipid infusion (group C), or 4 min/kg/min dextrose alone (group B) or with heparin and Intralipid (group D). Quinine (10 mg/kg) was also infused over 60 min in all cases. In patients of groups A and C, mean changes in plasma glucose concentrations from the beginning to the end of the infusion were 0.1 (SD 0.8) and 1.0 (SD 0.7) mmol/L respectively (P = 0.015). In groups B and D, plasma glucose increased by 1.8 (SD 1.2) and 2.2 (SD 0.4) mmol/L respectively (P < 0.5). Plasma FFA levels fell by approximately 50% during the infusion in groups A and B but increased by a similar percentage in groups C and D. Despite significant mean increases in plasma insulin during the infusion (from 12.2 milliunits (mu)/L in group A to 38.8 mu/L in group D), no rebound hypoglycaemia was observed in any patient during the ensuing 7 h. These data suggest that the glycaemic response to dextrose given at high rates, which match average glucose utilization in a severely ill patient with malaria, is not augmented by increased plasma FFA and long-chain triglycerides. However, this strategy increases the glycaemic efficacy of lower dextrose infusion rates and the combination could, therefore, reduce the volumes of hypertonic dextrose required to prevent hypoglycaemia in severely ill patients in whom optimal fluid balance is crucial.

Adult↗
PubMedDate not supplied

Improved diagnostic accuracy of planar imaging with technetium 99m-labeled tetrofosmin compared with thallium-201 for the detection of coronary artery disease.

BACKGROUND: Receiver operating characteristic (ROC) curve analysis provides detailed information about the performance of a diagnostic test. METHODS AND RESULTS: As part of a multicenter phase III trial, 160 patients with known or suspected coronary artery disease underwent planar stress-rest 99mTc-labeled tetrofosmin and stress-redistribution 201Tl imaging within 14 days of each other, to compare the diagnostic accuracy of these imaging modalities by ROC curve analysis. Coronary arteriography was used as the reference standard and greater than 70% stenosis was considered significant. ROC curve analysis showed improved detection of coronary artery disease with 99mTc-labeled tetrofosmin compared with 201Tl, with ROC curve areas of 0.765 versus 0.644, respectively (p = 0.02). 99mTc-labeled tetrofosmin also better identified single-vessel disease in those without previous myocardial infarction (ROC curve areas of 0.684 vs 0.510 for 99mTc-labeled tetrofosmin and 201Tl, respectively; p = 0.04) and enhanced the detection of multivessel disease in those with previous myocardial infarction (ROC curve areas of 0.764 vs 0.638, respectively; p = 0.02). CONCLUSIONS: Detailed assessment of diagnostic performance by ROC curve analysis shows that, for planar imaging, 99mTc-labeled tetrofosmin enhances the detection of coronary artery disease compared with 201Tl.

Adult↗