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Biomedical subjects

J C Cain

Publications and source records attributed to J C Cain.

4 recordsLinked to original sources

Continuing medical education.

1. Continuing medical education is unquestionably a worthwhile goal. Knowledge or exposure to information, however, does not ensure competence in medical care; nevertheless, without knowledge there is no possibility of true competence. 2. Continuing medical education should not be judged by recall knowledge but should ensure exposure to current and acceptable medical knowledge. 3. Because all licensed physicians have unrestricted licenses regardless of their specialty, they all should benefit from a comprehensive type of CME. 4. An open-book examination with reference sources appended to the questions would expose the physician to current and acceptable medical knowledge. 5. Recall types of examinations have no place in practical CME.

Education, Medical, Continuing

N-o-Methoxyphenylpiperazine: a simple blocker of dopaminergic receptors in the brain.

N-o-Methoxyphenylpiperazine (MPP) is a moderately effective in vivo blocker of dopaminergic receptors. Its ability to increase the concentration of rat brain homovanillic acid (HVA) and the resulting time course for HVA were similar to the actions of clozapine. The increased concentration of HVA did not result from decreased outflow from brain because HVA also rapidly decreased after a subsequent injection of pargyline. MPP blocked the circling behaviour caused by apomorphine in mice with a unilateral striatal lesion, and MPP and apomorphine reciprocally blocked the occurrence of stereotypy and increased HVA in rats. Diazepam partially prevented the MPP-induced elevation of HVA. Thus, both biochemical and pharmacological evidence indicate the dopaminergic blocking action of MPP.

Animals