Biomedical subjects

J C Borod

Publications and source records attributed to J C Borod.

At least 37 records · Page 2Linked to original sources

PubMed1998

A preliminary evaluation of emotional experience and expression following unilateral brain damage.

In this preliminary study, hemispheric specialization for the experience and expression of emotion was investigated. Subjects were right-brain-damaged (RBD), left-brain-damaged (LBD), and normal control (NC) right-handed adults, carefully matched on demographic and neurological variables. Facial expressions were videotaped while subjects described recollected emotional and nonemotional experiences. Expressions were later rated by trained judges for emotional intensity and category accuracy. To examine experience, subjects evaluated the intensity and accuracy with which they had produced their monologues. RBDs produced less intense facial expressions and reported less intense emotional experiences than LBDs and NCs. LBDs rated themselves as producing expressions with less accuracy than did RBDs and NCs. These findings are consistent with research that supports the right-hemisphere hypothesis for emotion. In addition, judges' ratings and subjects' self-reports of emotional intensity were positively correlated for normal but not for brain-damaged subjects.

Affect↗

PubMed1997

Neuropsychological aspects of facial asymmetry during emotional expression: a review of the normal adult literature.

This review focuses on facial asymmetries during emotional expression. Facial asymmetry is defined as the expression intensity or muscular involvement on one side of the face ("hemiface") relative to the other side and has been used as a behavioral index of hemispheric specialization for facial emotional expression. This paper presents a history of the neuropsychological study of facial asymmetry, originating with Darwin. Both quantitative and qualitative aspects of asymmetry are addressed. Next, neuroanatomical bases for facial expression are elucidated, separately for posed/voluntary and spontaneous/involuntary elicitation conditions. This is followed by a comprehensive review of 49 experiments of facial asymmetry in the adult literature, oriented around emotional valence (pleasantness/unpleasantness), elicitation condition, facial part, social display rules, and demographic factors. Results of this review indicate that the left hemiface is more involved than the right hemiface in the expression of facial emotion. From a neuropsychological perspective, these findings implicate the right cerebral hemisphere as dominant for the facial expression of emotion. In spite of the compelling evidence for right-hemispheric specialization, some data point to the possibility of differential hemispheric involvement as a function of emotional valence.

Adult↗

PubMed1996

Hemispheric specialization for discourse reports of emotional experiences: relationships to demographic, neurological, and perceptual variables.

This study examined hemispheric specialization for discourse reports of emotional and nonemotional experience in 16 right-brain-damaged (RBD), 16 left-brain-damaged (LBD), and 16 demographically-matched normal control (NC) right-handed adults. Patient groups did not differ on etiology, months post-CVA onset, and intrahemispheric lesion location. Subjects were requested to produce monologues about positive and negative emotional and nonemotional experiences. The lexical content of written transcriptions of these monologues was later rated for "emotionality" by naive judges. Overall, RBDs described experiences with less emotional intensity than did NCs and LBDs, providing support for right hemisphere involvement in lexical emotion. Although the RBDs in the current study demonstrated similar patterns of deficits in a prior study [9] on tasks involving lexical emotional perception, there were no significant relationships between the current measures of emotional expression and the previous measures of emotional perception. Finally, the expression and the perception data were examined with respect to intrahemispheric factors. Among the brain-damaged subjects, subcortical structures were more involved in reports of emotional experience, and cortical structures were more involved in the perception of emotion.

Age Factors↗

PubMed1996

Left and right hemispheric contributions to discourse coherence and cohesion.

Linguistic coherence and cohesion were examined in patients with unilateral left brain damage (LBD), unilateral right brain damage (RBD), and normal control (NC) right-handed adults. Groups were matched for age, gender, occupation, and education. Brain-damaged groups did not differ for months post onset or intrahemispheric lesion site. Contrary to previous literature, results indicated that LBDs, all of whom were aphasic, demonstrated impairments in coherence but not cohesion, relative to NCs and RBDs. Surprisingly, among RBDs, overall coherence and cohesion were spared. When the relationship between measures of coherence and cohesion was examined, there were few significant correlations and no systematic patterns. Results support the notion that coherence and cohesion represent coexisting and independent linguistic systems. Further, the findings suggest that descriptions of discourse integrity need to account for the perspective of both the speaker and listener.

Aged↗

PubMed1995

Modality dependent changes in event-related potentials correlate with specific cognitive functions in nondemented patients with Parkinson's disease.

The relationship between event-related potentials (ERPs) and cognitive functioning was studied in patients with Parkinson's Disease (PD) but without dementia. Auditory and visual stimuli were used; 30 subjects participated in the auditory study and 20 in the visual study. Patient groups did not differ with respect to gender, age, education, illness duration, and level of cognitive functioning. Visual stimuli were 2.3 cpd sinusoidal grating patterns randomly presented in an oddball paradigm (oblique vs. vertical spatial orientation). Auditory stimuli were tones presented at 70 dB SPL at a rate of 1.1/second, also using the oddball paradigm (1.5K vs. 1K tones). All patients were given neuropsychological tests to measure verbal fluency, memory, visual spatial perception, and abstract reasoning. P300 and N200 abnormalities correlated with a number of these measures, such that longer ERP latencies were related to lower scores on tests of cognitive functioning. Patterns of results suggest that auditory and visual ERPs correlate with different subsets of neuropsychological functions in nondemented PD patients and that N200 may provide a new metric for clinical use.

Cognition↗

PubMed1994

Hedonic ratings of odors as a function of odor sequence in older adults.

Pleasant and unpleasant odors were presented to 20 subjects in two same-valence blocks, i.e., all pleasant ones first, all unpleasant ones second, or vice versa, and in alternation. Hedonic ratings increased for the second block of odors which followed the first block of oppositely valenced odors. Alternation did not appear to affect hedonic ratings. These findings suggest that presentation of odors can alter hedonic ratings, producing a contrast effect when odors are given in a blocked fashion.

Aged↗

PubMed1993

Perception of facial emotion in schizophrenic and right brain-damaged patients.

Deficits in the perception of facial emotion have been demonstrated in patients with right-sided brain damage (RBD) and schizophrenia (SZ). Furthermore, recent speculations have implicated right-hemisphere dysfunction in Type II schizophrenics, especially those with a preponderance of "negative symptoms" and flat affect. The performance of SZ, RBD, and normal control subjects was compared on measures assessing facial emotional perception. Both identification and discrimination paradigms were used, with positive/pleasant and negative/unpleasant emotions. To examine the effects of visuospatial and facial processing on facial emotion tasks, the Visual Matrices Test and the Benton Facial Recognition Test were administered. On both facial emotion tests, SZ and RBD patients were significantly impaired relative to normal subjects, but not different from each other. The SZ and RBD patients were also impaired on the matrices and facial recognition tests. When the effects of the matrices and neutral face recognition tests were statistically controlled, significant group differences remained for the identification task but not for the discrimination task. Thus, methodologies are presented for the neuropsychological study of facial emotional perception, and some support is provided for the notion that negative-symptom schizophrenia is associated with right hemisphere dysfunction.

Adult↗

PubMed1993

Suppression and facilitation of pragmatic performance: effects of emotional content on discourse following right and left brain damage.

This study examines the effect of emotional content on the verbal pragmatic aspects of discourse production in right-brain-damaged (RBD), left-brain-damaged (LBD), and normal control (NC) right-handed adults. Subject groups were matched for gender, age, education, and occupation; brain-damaged groups did not differ on months post CVA onset and lesion location. Subjects were screened to ensure that they demonstrated adequate cognitive and visual perceptual skills to participate in the study. Pictorial stimuli were used to elicit discourse that contained emotional and nonemotional (procedural, visuospatial) content. Trained raters evaluated each discourse for appropriateness on seven verbal pragmatic features (e.g., conciseness, quantity, relevancy). Across all three conditions, the brain-damaged groups were impaired relative to NCs. In the nonemotional conditions, LBDs were particularly impaired in pragmatics, whereas in the emotional condition, RBDs demonstrated pragmatic deficits. Emotional content appeared to facilitate pragmatic performance among LBD aphasics and to suppress pragmatic performance among RBDs.

Aphasia↗

PubMed1992

Clustering strategies on tasks of verbal fluency in Parkinson's disease.

The verbal output of patients with Parkinson's disease (PD) was analyzed for semantic and phonemic clusters on tasks of verbal fluency. One task required cued retrieval by semantic category (i.e. animals), and one required non-cued retrieval by initial letter (e.g. words beginning with 'F'). Nondemented PD patients (N = 25) produced significantly fewer words on the cued semantic retrieval task than age-, gender- and education-matched normal control subjects (N = 22), but were not impaired on the non-cued letter retrieval task. However, overall, PD patients were able to form more semantic clusters than phonemic clusters. These results are discussed in light of other studies of verbal fluency deficits in patients with PD.

Aged↗

PubMed1992

Right hemisphere specialization for the identification of emotional words and sentences: evidence from stroke patients.

This study examines the contribution of the lexical/verbal channel to emotional processing in 16 right brain-damaged (RBD), 16 left brain-damaged (LBD) and 16 normal control (NC) right-handed adults. Emotional lexical perception tasks were developed; analogous nonemotional tasks were created to control for cognitive and linguistic factors. The three subject groups were matched for gender, age and education. The brain-damaged groups were similar with respect to cerebrovascular etiology, months post-onset, sensory-motor status and lesion location. Parallel emotional and nonemotional tasks included word identification, sentence identification and word discrimination. For both word tasks, RBDs were significantly more impaired than LBDs and NCs in the emotional condition. For all three tasks, RBDs showed a significantly greater performance discrepancy between emotional and nonemotional conditions than did LBDs or NCs. Results were not affected by the valence (i.e. positive/negative) of the stimuli. These findings suggest a dominant role for the right hemisphere in the perception of lexically-based emotional stimuli.

Aged↗

PubMed1992

Impact of emotional content on discourse production in patients with unilateral brain damage.

A picture story task was developed to examine expression of emotion via the verbal/lexical channel. The task elicited discourse with either emotional, visual-spatial, or neutral content and was administered to right brain-damaged (RBD), left brain-damaged (LBD), and normal control (NC) right-handed adults. Subjects were matched for gender, age, education, and occupational status. The brain-damaged groups were matched for months post-CVA onset and were similar with respect to intrahemispheric site of lesion. While the number of words produced was equivalent for each of the subject groups, the RBDs and LBDs expressed quantitatively less content than did the NCs. When content differences were examined within each subject group, there were no differences for LBDs and NCs, but the RBDs showed a selective deficit when producing emotional content. This finding suggests a special role for the right hemisphere in the production of emotional content in verbal discourse.

Adult↗

PubMed1992

Interhemispheric and intrahemispheric control of emotion: a focus on unilateral brain damage.

Neocortical contributions to emotional processing are discussed. First, parameters critical to the neuropsychological study of emotion are examined: interhemispheric (right, left) and intrahemispheric (anterior, posterior) factors, processing mode (expression, perception), and communication channel (facial, prosodic, lexical). Second, neuropsychological theories of emotion are described: right-hemisphere and valence hypotheses. Third, experimental studies of right-brain-damaged, left-brain-damaged, and normal adults are reviewed, on the basis of mode and channel, with a focus on stroke. Findings support right cerebral hemispheric dominance for emotion, regardless of valence and channel, and are more consistent for perception than expression. When lesion site is a factor, posterior sites are important for perception and anterior ones for expression. Finally, clinical implications are suggested for aphasia rehabilitation and for assessment of affect in neurological disorders.

Adult↗

PubMed1992

Set-shifting and spatial orientation in patients with Parkinson's disease.

Individuals with Parkinson's disease were compared to normal control subjects on a series of widely used neuropsychological measures. The two groups were matched for gender, handedness, age, education, and occupation. The neuropsychological tests were chosen to measure two specific functions: (a) spatial orientation (i.e., measures of personal orientation, extrapersonal orientation, right/left orientation, and mental rotation), and (b) the ability to shift mental set (e.g., generating responses from alternating categories). The tests chosen to measure spatial orientation had no set-shifting component, and the tests chosen to measure set-shifting had no spatial orientation component. Multivariate statistical analyses revealed a significant difference between the subjects with Parkinson's disease and the control subjects on the measures of set-shifting ability. In contrast, no significant difference between the groups was observed on the measures of spatial orientation. These results are discussed in terms of the current speculation in the literature regarding the relationship between set-shifting deficits and a disruption of dopaminergic fibers to the prefrontal cortex in Parkinson's disease.

Aged↗

PubMed1990

Neuropsychological aspects of Parkinson's disease.

The neuropsychological effects of Parkinson's disease have gained wide recognition in recent literature. Effects have been documented in almost all areas of cognitive functioning, including general intellectual functioning, visual-spatial functioning, executive functions, attention and memory functions, language functions, and affective processes. Visual-spatial functions, memory functions, and executive functions have received particular interest. This review of the literature is an attempt to tie together the large number of studies in these cognitive areas and to present a suggestion for a comprehensive neuropsychological battery tailored to the patient with Parkinson's disease. Throughout the review, factors relevant to Parkinson's disease, e.g., dementia, motor symptoms, and hemiparkinsonism, are considered.

Alzheimer Disease↗

PubMed1990

The auditory P 300 correlates with specific cognitive deficits in Parkinson's disease.

An abnormally prolonged latency of the P 300 event-related potential has been reported in several types of dementing illnesses, including Parkinson's disease (PD). While some PD patients have dementia, a significant number of PD patients have less severe cognitive impairments. We examined the relationship between the auditory P 300 and a neuropsychological battery of 11 tasks in 43 PD patients. The quantitative relationship between the individual neuropsychological measures and the P 300 was examined using partial correlation and analysis of covariance techniques which controlled for age, education, and illness duration. The strongest correlations were between P 300 and both short-term memory and visual perception. Global cognitive deficits do not appear to relate to the abnormal P 300 responses in PD: instead, specific aspects of cognitive decline accounted for the electrophysiological abnormalities. An abnormally long or absent P 300 correlated with deficits on select cognitive tasks: those involving memory, visual perception, and abstract reasoning. The interactions between anatomical and neurochemical abnormalities in PD are discussed in light of the pattern of deficits seen in this study.

Adult↗

PubMed1990

Lateralization for the expression and perception of facial emotion as a function of age.

In order to test the hypothesis of right hemisphere changes with age, this study examined lateralization for facial emotion in young, middle-aged, and older women (N = 90). For expression, subjects were photographed while posing positive and negative emotions. Composite photographs were created and rated for intensity. For perception, subjects were required to make intensity judgements about emotional chimeric faces. Overall, subjects demonstrated significant left-sided facial asymmetry for expression and significant left hemispace biases for perception. The findings for facial expression were not influenced by emotional valence or resting face asymmetries. There were no changes in lateralization as a function of age for either expression or perception. Taken together, these findings lend support to the notion that the right hemisphere mediates emotional processing across the adult life span.

Adult↗

PubMed1990

Perceiver and poser asymmetries in processing facial emotion.

This study examined both perceiver and poser asymmetries in processing facial emotion. Posers were left brain-damaged (LBD), right brain-damaged (RBD), and normal control (NC) right-handed males videotaped while expressing happiness and anger. Perceivers rated the facial expressions for asymmetry in original and reversed orientations. Overall, expressions viewed in the reversed orientation were rated as more left-sided than in the original orientation. In the reversed orientation, the more extensive left hemiface of the NCs and LBDs fell in the perceiver's left hemispace. This finding is consistent with previous research demonstrating a left hemispace bias for free-field viewing of emotional faces. Expressions were produced significantly more intensely on the left than the right hemiface by NCs and LBDs; expressions of RBDs were not significantly lateralized.

Adult↗

PubMed1990

A preliminary characterization of lexical emotional expression in right and left brain-damaged patients.

Disorders in nonverbal communication of emotion have been documented in patients with right hemisphere pathology; lexical expression of emotion is virtually unstudied. In this preliminary investigation, emotionally laden slides were used to elicit discourse from right brain-damaged (RBD), left brain-damaged (LBD), and normal control (NC) subjects. New techniques were developed to examine the ability of these subjects to express emotion in words; formalistic and pragmatic analyses of the discourse were conducted. RBDs, relative to NCs and LBDs, were less successful in using words to convey emotion and produced words of lower emotional intensity. LBD aphasics, despite their linguistic deficits, were comparable to NCs in conveying emotional valence. The data tend to support the speculation that the right hemisphere is dominant for lexical expression of emotion. This study has implications for the neuropsychological investigation of language, emotion, and the brain.

Brain Damage, Chronic↗