Search PubMed⌕ Search

Biomedical subjects

J C Bonneau

Publications and source records attributed to J C Bonneau.

At least 37 records · Page 2Linked to original sources
PubMed1991

[General considerations on desensitization by the sublingual route].

A favourable action by a new method of therapy and in particular desensitization by the sub-lingual route is sometimes difficult to confirm. To make a sensible study requires a maximum of prior knowledge and this is not easy to acquire. How to select the patients? What method of administration is possible? What should be the dose adopted? What might be the secondary effects? Desensitization by the sub-lingual route seems to us to be a technique for the future. Impressions and thoughts on the new method route for desensitization must lead to controlled studies, very objective, which will confirm or invalidate it.

Administration, Sublingual↗
PubMed1991

[Immunological causes of male infertility].

Sperm (spermatozoa and the various secretions of the accessory glands) with its very complex antigenic system is only produced from puberty and thus at a time when the body has already had a for a long time the facility to respond to an antigenic stimulation with an immune reaction. Because of this, the spermatozoa, in contrast to other cells of the organism, are considered as strangers and may behave as auto-antigens. However, the existence of a haemato-testicular barrier, that prevents all contact between the sperm and the immune system must be recognized in man, its rupture has the consequence of formation of anti-spermatozoa antibodies. It is estimated that 5% of cases of sterility are of immunological origin and linked to the presence in man and/or woman of anti-sperm antibodies. The production is greater in man than in women because of the roles, in the first of macrophages and in the second of polynuclear neutrophils in the destruction of the spermatozoa. Anti spermatozoal antibodies play a part in sterility by: Spontaneous agglutination in ejaculation, thus preventing their progression in the female genital tract. Free spermatozoa, charged with antibody are retained at the level of the cervical secretion = SHAKING phenomenon. The anti-spermatozoal antibodies mask some antigens, so preventing penetration of the spermatozoa into the ovule. Contact of spermatozoa with antibody fixed to the uterine tissue is followed by secretion of histamine and this encourages the expulsion of an implanted egg. This is before the existence of: Spontaneous agglutination in ejaculation, Oligospermatosis, Indeterminate cause sterility, Immobilisation of the spermatozoa in the cervical secretion, Failure of repetition.

Antibody Formation↗
PubMed1991

[Allergy survey in genital contact dermatitis].

Contact eczema is one of the most frequent dermatological affections, regardless of age and sex. In typical cases, the diagnosis is usually easy, but it may be less so where there are atypical factors, in particular locations and with complications or unusual etiological data. In fact, the first condition in making a diagnosis is to suspect that there is the possibility of contact allergy. As an example, it should be remembered that allergy to benzalkonium can be diagnosed after a mean time of 87 months of evolution. The present availability of standardised allergens for testing for contact allergens has greatly changed the diagnostic possibilities. The allergens that are most often the cause in the genital region are perfumes, chlorhexidine, hexamidine, benzylalkonium chloride and latex. Only recognition of the allergen and its removal are used and sufficient to obtain recovery.

Allergens↗
PubMed1991

[Refractory vaginal candidiasis].

Genital candidiasis is a poorly-studied pathology, certainly because there is often a favourable result after treatment, at least in times past. If the diagnosis of acute vulvo-vaginitis is easy, it is not the same in relapse or second attack. The correct treatment of refractory vaginal candidiasis and/or second attacks needs a knowledge of their etiology, the mechanisms that encourage their appearance (and maintenance), the field where they occur. Recent data on the action of Candida on immunity may introduce new physiopathological perspectives and treatments.

Candidiasis, Vulvovaginal↗
PubMed1990

[Mercury--is it a respiratory tract allergen?].

Mercury is a well-known allergen in dermato-allergology, often manifesting as delayed type hypersensitivity contact eczema. Immediate hypersensitivity reactions (urticaria, anaphylactic shock) have also been described for this allergen, most frequently seen in patients with the delayed type contact eczema. To our knowledge this allergen has not been implicated in production of respiratory symptoms. We describe a patient who had aggravation of asthma by mercury contained in dental amalgam. When the dental amalgam was removed there was a great improvement in his asthma. This observation suggests that mercury in the form of dental amalgam may also be an allergen of the respiratory tract, which should not be surprising, bearing in mind the work that shows the existence of mercury vapours from dental amalgam.

Adult↗
PubMed1990

[Clinical diagnosis of asthma].

Paroxysmal wheezing dyspnea, asthma may evolve from a simple crisis to an asthmatic attack that repeats several crises daily with duration up to several weeks, in some months when the asthmatic illness becomes life-threatening. Chronology of asthma is related to bronchial inflammation without knowing how to avoid the development of complications. Childhood types and those of subjects of more than 65 years are well characterised by mechanisms of bronchial hyper-reactivity that are always found and are identical to the type found in young adults. There are "limited" types that need respiratory function tests for confirmation of asthma.

Adolescent↗
PubMed1990

[Rhinomanometry: indications, limitations and results].

The aim of this study was to present briefly the different techniques for measurement of nasal resistance and to show the importance that we attribute to this measurement. Within the framework of the allergological investigation rhinamometry is a parameter that allows evaluation of the results of allergenic nasal provocation. Nasal provocation is in the framework as a complementary examination that is often indespensable to confirm with most possible certainty the involvement of an allergen in the ORL pathology. Positive etiological diagnosis is a fundamental basis for therapeutic advice.

Airway Resistance↗
PubMed1990

[Fernand Widal syndrome and sulfite intolerance. Therapeutic problems in general and ORL problems in particular].

Asthma from intolerance of sulphites has been the subject of clinical work by our team since 1984. In 1986, we advised that asthma from sulphite intolerance was more frequent in patients who presented with illness from aspirin or the Fernand Widal syndrome. So it has emerged that there are clear therapeutic problems since sulphites as preservatives are present in other forms in some anti-allergy drugs, anti-histamines used for ORL.

Aspirin↗
PubMed1990

[The environment and perennial rhinitis in the child].

In assessing the importance of the "allergen eviction" factor in the treatment of infantile allergies, the authors begin an inventory of those elements in the environment that concern perennial rhinitis. From 200 observations of allergic children (all mixed diagnoses) they found 21 observations of rhinitis alone, predominantly boys. The environments of two groups (all allergics--rhinitis alone) were compared. No difference for: Home, country, town heating allergens found. Found significant differences for the type of house new-old those elements of domestic comfort (carpets, feather beds, aeration, soft toys) agreement between the results of tests and the environment domestic animals or permanent proximity. Found fundamental differences for psychological environmental factors (absent in rhinitis). It seems that perennial rhinitis probably arises from abundance of domestic antigens more than for the other allergic manifestations, as the nose is the first filter to receive foreign particles.

Adolescent↗
PubMed1989

[Anaphylaxis induced by exercise].

Exercise-induced anaphylaxis EIA is a syndrome most often initiated by food allergy. Objective or diagnostic proof of the condition is shown by a provocation test from ingestion of a food before or after exercise, according to clinical history, with assay of plasma histamine and spirometry or rhinamometry. The original part of this work is evidence of EIA linked to food allergy to wheat, with cross reactivity to grass pollens.

Adolescent↗
PubMed1988

[Antihistaminic or anti-degranulating activity of pregnancy serum].

From observation of women who had anaphylactic accidents to hymenoptera venoms, with positive histamine release, we have noticed that these same patients lose their histamine release during pregnancy. Measurement of histamine release to pollens confirms the existence of a histaminase, which develops from the third month of the pregnancy and which is the origin of the loss of histamine release. This study makes eliminates a possible anti-degranulation ability of pregnancy sera.

Amine Oxidase (Copper-Containing)↗
PubMed1988

[Bibliographic review of antihistaminics H2 in the treatment of chronic (or recurrent) idiopathic urticaria].

Cimetidine alone has not been shown conclusively to be effective in the treatment of urticaria. Cimetidine in combination with an H1 antihistamine has been shown to be effective in studies of patients who could not be controlled by H1 antihistamine alone. In that section of the patient population with "untreatable" chronic urticaria, the use of an H2 antagonist in conjunction with an H1 antagonist should be considered as a possible treatment.

Histamine H1 Antagonists↗
PubMed1988

[Local and general experimental anti-anaphylactic effect of 554 L, a synthetic antihistaminic].

554 L, a synthetic histamine depressant, was first made in September 1956. In spite of the age of this compound, it seemed to us that it may be of interest to examine it for possible experimental general and localised bronchial antianaphylactic activity. In the first experiments, the results showed an anti-anaphylactic effect in guinea pigs that had been sensitised to cow milk. The second study proved that there was an anti-anaphylactic effect locally on the bronchii by an aerosol of 554 L or Hypostamine on guinea pigs that were sensitive to OVA. These results may produce development of this old compound in delayed release and aerosol presentations.

Animals↗
PubMed1988

[Type I hypersensitivity to latex].

Allergy to latex causes serious accidents that are often unrecognised. These accidents are perfectly predictable by a simple interrogation, together with skin and biological tests. Populations at risk can be identified: persons undergoing treatment, particularly the disabled and also housewives. There is a risk of further increases in the number of cases of hypersensitivity to latex due to the expanding use of preservatives. The study undertaken at the CHU at Angers has shown that allergy to fruits is frequent in patients who are sensitive to latex. The exact nature of allergy to Hevea is not yet well understood: it is not possible at present to decide whether there is "crossed allergy" or whether it is one part of a larger syndrome.

Adult↗
PubMed1988

[Cell-mediated immunity using anti-influenza vaccine (AIV) and an immunostimulant (R)].

21 infected asthmatics were involved in this study, divided into three groups: Group 1 (G1): 7 subjects who received Ribomunyl. Group 2 (G2): 7 subjects who received anti-influenza vaccine, replaced on the 8th day by Ribomunyl. Group 3 (G3): 7 subjects who received the anti-influenza vaccine. Every patient had a IMC assessment on days 0, 8 and 30 that was composed of: 1. An RE test to show the Ly T11 receptors. 2. A study of the lymphocyte sub-populations CD3, CD4 and CD8, that respectively exhibit the LyT, T-helper and T-suppressor receptors. 3. Lymphocyte function was studied by stimulation of the lymphocytes by lectins, PHA (Ly T), Con A (Ly Ts) PKWM (Ly 8): by TB co-operation). 4. Measurement of total IgE. Only the lymphocyte stimulation tests by lectins showed a significantly raised response in the subjects of G1, who received Ribomunyl. IAV and Ribomunyl (G2) or IAV alone (G3) showed lymphocytes responses that were statistically less than G1. It seemed as though the IAV retarded the Ribomunyl response in IMC. The RE test and the study of the sub-populations did not show any significant differences between the groups. No differences between the total IgE levels could be seen in the groups. This study indicates the possibilities in the treatment of super-infected asthmatics with Ribomunyl alone, since the anti-influenza vaccine had a tendency to retard cell-mediated immunity.

Adjuvants, Immunologic↗
PubMed1988

[Open trial on the tolerance to Rhinaaxia in allergic rhinitis].

Forty-four patients, most of them with strong symptoms, were included in this study of the tolerance and efficacy of Rhinaaxia in the treatment of allergic rhinitis. Thirty two patients had good or very good tolerance. Others reported nasal irritation and sneezes after the sprays and one left the study for this reason. The efficacy on nasal symptoms is also very clear. On the third day of treatment the decrease of the nasal trouble was already significant.

Aerosols↗
PubMed1987

[Hyper-accelerated immunotherapy with Hymenoptera venoms].

Hyper-accelerated immunotherapy with hymenoptera venoms. Immunotherapy with hymenoptera venoms can be done in 3.5 to 6 hours, in a hospital environment with the precaution of having made a threshold of cutaneous sensitivity. The 3.5 h technique should only be used for subjects who are weakly sensitive to wasp venom. The 6 h technique should be used for: Subjects with weak sensitisation to been and hornet venom. Those who are strongly sensitive to wasp venom. The 3 day technique should be used for those who are strongly sensitive to been and hornet venom. This division of the indications is essentially based on skin tests. By its use, systemic reactions or indeed anaphylaxis that may occur during desensitisation may be avoided.

Anaphylaxis↗