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Biomedical subjects

J C Bessot

Publications and source records attributed to J C Bessot.

At least 73 records · Page 4Linked to original sources
PubMed1980

Meat wrapper's asthma: identification of the causal agent.

Meat wrapper's asthma is a typical example of occupational asthma due to emissions from chemical products. The authors report three new cases due to the use of the now classic meat packaging techniques in supermarkets. The chemical agents involved were identified. Inhalation tests have been carried out in one patient with the complete wrappings, i.e. the PVC film and the price labels, and separate tests were performed with eight additives of the PVC film, and with phthalic anhydride and di-cyclohexylphthalate emitted from heated price labels. These tests incriminate two products: phthalic anhydride seems to be the principal causal agent and epoxidized soybean oil can be suspected as a secondary agent causing this occupational asthma.

Adult↗
PubMed1980

Is tartrazine-induced asthma related to inhibition of prostaglandin biosynthesis?

Since it has been suggested that aspirin-induced asthma is due to inhibition of prostaglandin (PG) biosynthesis, the present investigation was undertaken to determine whether tartrazine would display a similar profile. Use was made of the exquisite sensitivity of blood platelets, both in humans and in rats, to aggregating substances generated from arachidonic acid during PG biosynthesis and of the ability of aspirin to inhibit aggregation and generation of those substances. Failure to affect aggregation by arachidonic acid as well as the accompanying formation of thromboxane A2, demonstrates that neither tartrazine nor its metabolite sulfanilic acid inhibit platelet PG synthesis. It seems unlikely that tartrazine-induced asthma results from inhibition of PG biosynthesis.

Aspirin↗
PubMed1980

["Active" rosettes and skin tests to recall antigens and phytohemagglutinin in 48 patients with non metastatic squamous cell lung carcinoma and before treatment (author's transl)].

Looking for an early immune defect assay in non metastatic (MO) squamous cell lung carcinoma, 48 untreated patients were tested at the time of diagnosis for peripheral blood "active" rosette-forming T lymphocytes, delayed cutaneous hypersensitivity to recall antigens and skin reactivity to phytohemagglutinin (PHA). 32 patients had a resectable tumour (group 1) and 16 patients had a loco-regional extension which made the tumour inoperable (group 2). No significant difference (p greater than 0.05) was observed between any of the two groups of patients and normal controls nor between group 1 and 2 for "active" rosettes and skin tests to recall antigens. However, skin reaction to PHA was significantly impaired in patients of both groups compared to normal age-matched controls whatever the dose of PHA (4 microgram and 10 microgram). The number of unreactive patients in group 2 was higher than in group 1, but the difference was not significant (p greater than 0.05). It is concluded that skin reactivity to PHA is an useful and easy assay for cell-mediated immunity deficiency in early squamous cell lung carcinoma, whereas "active" rosettes are not altered.

Carcinoma, Squamous Cell↗
PubMed1979

Inhibition experiments with solid phase mite or epithelia in house dust hypersensitivity.

The present study was undertaken to verify that mites are not the only allergens in house dust extracts and that other allergens such as cat epithelia can also be responsible for house dust hypersensitivities detected both by house dust skin tests and house dust RAST studies. In order to determine whether mite or epithelia fixed on a solid phase could remove not only the IgE antibodies reactive with the homologous allergens, but also the IgE antibodies reactive with house dust allergens, the authors have absorbed 10 sera of house dust allergic patients with solid phase mite or epithelia. The absorption procedure removed a large part of the IgE antibodies reactive with specific immunosorbent (Dermatophagoides pteronyssinus or cat epithelia) and in the same way the IgE antibodies reactive with house dust immunosorbent. The percentage of RAST inhibition varied from 65% to 92% for Dermatophagoides pteronyssinus and from 65% to 94% for house dust in patients allergic to house dust and mite; the percentage of RAST inhibition varied from 67% to 92% for cat epithelia and from 73% to 90% for house dust in patients allergic to house dust and cat epithelia. This is in accordance with the hypothesis that house dust is not an allergen per se, but rather a complex mosaic of several allergens including mite, animal epithelia, etc.

Absorption↗
PubMed1979

[Clinical, pathologica and genetic analysis of 53 cases of broncho-pulmonary cancer, still surviving after 5 years (author's transl)].

The authors take up again the clinical, pathological and genetic analysis of 53 bronchial cancers with a survival exceeding 5 years. The operation samples were reexamined; a H.L.A. grouping was done in every cases. On the whole, it concerned patients under 60 in good general condition; the extension of their lesions only required a limited exeresis (lobectomy). The epidermoid form predominates, the lymph node invasion is rare. Seventy four per cent of the patients carry at least one of the following antigens: W 19, A 10, B 5, BW 35. But the study did not prove the existence of a genetic factor conditioning the survival.

Bronchial Neoplasms↗
PubMed1978

[Hereditary antithrombin III deficiency causing recurrent thrombo-embolic problems (author's transl)].

A marked deficiency in antithrombin III (AT III) was demonstrated in a 39-year-old man suffering from recurrent thrombo-embolic problems. The patient's father had died following a thrombo-embolic disorder. A certain number of members of the family also showed evidence of a marked decrease in AT III levels. Although it was not possible to study the patient's parents, it would seem reasonable to conclude that the diagnosis was one of hereditary deficiency in AT III. The various aspects of this disorder discovered by Egeberg are reviewed: early onset, in several members of the same family, or recurrent thrombo-embolic problems, accompanied by a decrease in functional activity of one of the principal inhibitors of thrombin (AT III), with autosomal dominant transmission and treatment based upon anti-vitamin K agents.

Adult↗
PubMed1977

Correlation between skin tests, inhalation tests and specific IgE in a study of 120 subjects allergic to house dust and Dermatophagoïdes pteronyssinus.

The radioallergosorbent test was compared with currently accepted allergy diagnostic techniques in seventy-four controls and 120 patients with a clinical history of allergy to house dust and Dermatophagoïdes pteronyssinus. The results obtained with D. pteronyssinus allergen extract show a close correlation between the size of the cutaneous reactions and the serum level of allegen-specific IgE. On the other hand, highly positive skin tests to house dust were not always correlated with a positive RAST response for house dust. Similar results were found with inhalation tests. When a purified D. pteronyssinus extract was used, a stronger relationship was observed between RAST, cutaneous and inhalation tests. It can be assumed that RAST for house dust is not of value in patients with house dust and mite allergy. Our findings indicate that the correlations between RAST results and other in vivo test results depend on the purity of the allergen extracts and the selection of patients.

Administration, Intranasal↗
PubMed1977

["Immuno-allergic" complications of rifampicin therapy].

From 8 cases of immuno-allergic accidents attributed to Rifampicine, the authors review the literature on the subject. The "flue like" syndrome is the most frequent and characteristic of those accidents, worsened by haematological and renal involvements. These accidents probably belong to a pathology of immuno-complexes in relaiton with the production of anti-Rifampicine antibodies. Among the different means of in vitro diagnosis, the test with the anti-complement antiglobulin is the most reliable, though not always in good correlation with clinical signs. Though rare and most often benign, these accidents should lead to prudence in treating recurrent tuberculosis or reusing Rifampicine after a momentary interruption.

Aged↗
PubMed1976

[Value of specific IgE levels in the etiological diagnosis of asthma].

The authors report a study of skin and inhalation tests and of specific IgE in 76 control subjects and 180 patients with allergic asthma. There is a remarkable correlation between the skin tests and the R.A.S.T. in pollinosis (96% of correlation) and in the respiratory allergy to Dermatrophagoides pteronyssinus (120 patients and 87.5% of correlation). It is good in the allergy to animal dander (82% of correlation) but poorer in the respiratory allergy to house dust (62% of correlation). The comparative study of inhalation tests and R.A.S.T. confirms that the degree of correlation depends on the quality of the allergens and on the patients selection. With the extract of house dust (101 cases) the correlation is only of 61.9%, whereas it reaches 95% with a purified extract of Dermatophagoides pteronyssinus (38 cases). The comparison between the treshold of allergenic sensitivity and the group of R.A.S.T. shows that to one group of high R.A.S.T. usually corresponds a low treshold of bronchial sensitivity (D.L.A.L. less than 100 gamma of extract of D. pt. in 22 patients having a R.A.S.T.D. pt. of group 3 or 4). Besides being valuable in characterizing allergens, the R.A.S.T. when confronted to the case history, to skin and inhalation tests, provides supplementary information leading to a more precise allergological diagnosis. In respiratory allergies caused by well known allergens (pollen, Dermatophagoides pteronyssinus), the R.A.S.T. could be substituted to skin and inhalation tests, when in agreement with clinical data. In doubtful cases, the inhalation tests would still keep their value and the confrontation of different techniques is necessary.

Acari↗