Detailed interview data from 250 male narcotic addicts attending methadone maintenance treatment centers in Baltimore and New York City were used to confirm and extend previous findings regarding the frequency of nonnarcotic drug abuse among relevant addict subgroups. Consistent with earlier results, abuse of nonnarcotic drugs in general, and particularly cocaine, was higher during periods of addiction than during periods of nonaddiction. Overall, marijuana and cocaine were the two main drugs of abuse, but variations were present according to addiction status period, city, and ethnic group membership. Relationships between cocaine use and specific types of criminal activity were also examined. It was found that there were high associations between cocaine use and several different kinds of crime.

Adult↗

PubMedDate not supplied

Mutagenicity studies of p-substituted benzyl derivatives in the Ames Salmonella plate-incorporation assay.

The mutagenicity of 24 benzyl derivatives, containing a variety of substituents and leaving groups, were assayed in strain TA100 using the Ames plate-incorporation assay. p-Nitrobenzyl chloride (12 000 revertants/mumole), p-nitrobenzyl tosylate (6100 revertants/mumole), and p-acetoxybenzyl chloride (100 revertants/mumole) were mutagenic; none of the remaining 21 compounds were mutagenic. p-Nitrobenzyl chloride was also found to be mutagenic in strain TA98 (700 revertants/mumole), but not in strain TA98NR (a strain deficient in nitro reductase activity). p-Acetoxybenzyl chloride was nonenzymatically hydrolyzed to p-hydroxybenzyl alcohol and p-acetoxybenzyl alcohol. These findings suggest that nitrobenzyl derivatives were mutagenic due to nitro reductive metabolism and that p-acetoxybenzyl chloride was mutagenic due to the intermediate formation of p-hydroxybenzyl chloride during the hydrolysis of p-acetoxybenzyl chloride.

Benzyl Compounds↗

PubMedDate not supplied

A preliminary study of an iron porphyrin-iodosylbenzene system for activation of mutagens in the Ames assay.

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Benzo(a)pyrene↗

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MNDO calculations of highly mutagenic (chloromethyl)benzo[a]pyrenes.

(Chloromethyl)benzo[a]pyrenes (ClMeB[a]P) are among the most potent direct-acting mutagens (i.e., not requiring metabolic activation) detected by the Ames assay using strain TA98 and TA100. We wanted to determine if molecular quantum mechanics would yield insights into the reactivity and mutagenicity of these compounds. Calculations using the MNDO semiempirical method (MOPAC program) were carried out on a series of ClMeB[a]P. The experimental rates of solvolysis of ClMeB[a]P in 50% aqueous acetone correlated well (r = -0.95) with the differences between the calculated heats of formation of ClMeB[a]P and those of their respective carbocations, supporting the hypothesis that ClMeB[a]P react via carbocations. None of the calculated parameters correlated with mutagenicity. Thus, the prediction of mutagenicity of ClMeB[a]P in the Ames assay is more complex than the simple formation of carbocation intermediates.

Animals↗

PubMedDate not supplied

What can we know about addiction from the addicts we treat?

The present paper examines the limitations that are placed on our understanding of addiction when research is restricted to studying opiate users who are seeking treatment. Though users who do seek treatment do not seem to differ in terms of their history or magnitude of drug use from those not seeking treatment, those in treatment are likely to have more serious addiction-related problems. Addicts who seek different types of treatment (e.g., methadone maintenance vs therapeutic community) appear to differ in terms of social and psychological characteristics. However, specific characteristics do not appear to be matched with specific treatments. Thus the addicts seen in treatment in general or in any specific treatment represent a discrete subpopulation of the entire population of opiate users. As such, any generalizations that we make about addiction based on these addicts must be limited.

Heroin Dependence↗