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Biomedical subjects

J C Anderson

Publications and source records attributed to J C Anderson.

252 records · Page 14Linked to original sources
PubMedDate not supplied

CT and MRI findings in sclerodermatous chronic graft vs. host disease.

Sclerodermatous chronic graft vs. host disease is a well-documented complication of bone marrow transplantation, however has not previously been described in the radiology literature. We present the imaging findings of this disease including the ability to identify active disease and aid in clinical management.

Abdominal Muscles↗
PubMedDate not supplied

Repair of an osteochondral tumor of the talus utilizing a fresh-frozen cadaveric graft.

A case involving a benign osteochondral tumor of the talar dome is presented. Graft considerations are reviewed and some of their specific characteristics are highlighted. Selection of a fresh-frozen cadaveric graft in this case was based on the goal of maintaining articular congruity in the ankle joint. The authors' experience demonstrated that normal joint function can be preserved with this type of graft.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

Form, function, and intracortical projections of neurons in the striate cortex of the monkey Macacus nemestrinus.

Single neurons were recorded in the striate visual cortex (area 17) of the old-world monkey Macacus nemestrinus. Eight pyramidal neurons, seven spiny stellate neurons, two basket cells, a clutch cell, and a chandelier cell were filled intracellularly with HRP. Their receptive fields were consistent with previous single-unit studies. Their axonal arbors were less elaborate than in equivalent neurons in the cat, but the laminar specificity of the boutons was very much more precise in the monkey than in the cat. Nevertheless, the basic cortical circuits in cat and monkey appear to be very similar.

Animals↗
PubMedDate not supplied

Estimates of the net excitatory currents evoked by visual stimulation of identified neurons in cat visual cortex.

The action potential discharge response of single neurons to both visual stimulation and injections of current were obtained during intracellular recordings in cat visual cortex in order to estimate the net excitatory current arriving at the soma during visual stimulation. Of 45 neurons recorded intracellularly, 19 pyramidal neurons and one basket cell were labelled with horseradish peroxidase. The discharge of all neurons adapted to constant current. For 40 neurons, a single exponential provided a good fit to the adapting discharge (r2 = 0.73 +/- 0.03) for all current intensities. Superficial layer neurons were significantly faster adapting [P < 0.001, mean (+/- SEM) time constant of adaptation = 11.5 +/- 1.3 ms; n = 20] than deep layer neurons (mean time constant of adaptation = 51.4 +/- 6.4 ms; n = 10). The percentage adaptation of the spike frequency, %(peak - adapted rate)/peak, was determined from the fitted exponential. Superficial layer neurons adapted significantly more strongly (P < 0.01, mean = 67 +/- 3%) than deep layer neurons (mean = 51 +/- 5%). The mean firing frequency in response to a current step of 320 ms duration had a linear relationship to the amplitude of the injected current (slope 66 spikes/s/nA; origin zero, mean r2 = 0.94; n = 33). This relationship provided a means of estimating the net peak excitatory current generated by visual stimuli. The estimated mean peak somatic current during the passage of a bar across the receptive field was 1.1 nA and the average current for the duration of the visually evoked discharge was 0.64 nA (n = 17). The transfer response of real and model neurons was obtained by differentiating the discharge response to a step input current and was then used to predict the output of the neuron following an arbitrary input. When these transfer responses were convolved with known input signals in model neurons, the predicted output was close to the simulated response of the model neuron to the same input waveforms. The transfer response was calculated for eight real neurons. Estimates of the net excitatory current arriving at the soma during visual stimulation was obtained by deconvolution. The mean peak somatic current for these neurons was 0.62 nA.

Action Potentials↗
PubMedDate not supplied

MR imaging of a hepatoma associated with Alagille syndrome.

Alagille syndrome is a rare cause of chronic liver failure which may be treated by liver transplantation. When underlying hepatic tumor is present, transplantation has had poor results. Magnetic resonance imaging may be a sensitive, noninvasive method to evaluate the presence of tumor before transplantation.

Abnormalities, Multiple↗
PubMedDate not supplied

Business marketing: understand what customers value.

How do you define the value of your market offering? Can you measure it? Few suppliers in business markets are able to answer those questions, and yet the ability to pinpoint the value of a product or service for one's customers has never been more important. By creating and using what the authors call customer value models, suppliers are able to figure out exactly what their offerings are worth to customers. Field value assessments--the most commonly used method for building customer value models--call for suppliers to gather data about their customers firsthand whenever possible. Through these assessments, a supplier can build a value model for an individual customer or for a market segment, drawing on data gathered form several customers in that segment. Suppliers can use customer value models to create competitive advantage in several ways. First, they can capitalize on the inevitable variation in customers' requirements by providing flexible market offerings. Second, they can use value models to demonstrate how a new product or service they are offering will provide greater value. Third, they can use their knowledge of how their market offerings specifically deliver value to craft persuasive value propositions. And fourth, they can use value models to provide evidence to customers of their accomplishments. Doing business based on value delivered gives companies the means to get an equitable return for their efforts. Once suppliers truly understand value, they will be able to realize the benefits of measuring and monitoring it for their customers.

Commerce↗
PubMedDate not supplied

Sedation of children for CT and MRI scanning.

This paper reports on 350 pediatric patients who were studied over a 17-month period to determine the efficacy and safety of oral and intramuscular sedation techniques. The protocol using oral chloral hydrate, 50 mgm/kg, for infants under 1 year of age or intramuscular pentobarbital, 5 mgm/kg, for children over 1 year was found to be an effective, safe and fairly simple approach to pediatric sedation. Of the 350 sedated patients, 343 (98 percent) had satisfactory scans on the same day the examination was scheduled after a single dose or an initial dose and supplementary sedation.

Administration, Oral↗