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Biomedical subjects

J C Alexander

Publications and source records attributed to J C Alexander.

78 records · Page 5Linked to original sources
PubMedDate not supplied

Effect of linamarin on thiocyanate production and thyroid activity in rats.

The principal cyanogenic glucoside in cassava is linamarin (2-hydroxyisobutyronitrile-beta-D-glucoside). Addition of pure linamarin to a diet based on 10% vitamin-free casein did not affect the weight gain of rats. However, as expected, the animals that received the casein diet supplemented with methionine gained more weight than those that received the unsupplemented diet. The amount of thiocyanate ion excreted in the urine by the animals that received linamarin was higher than that excreted by the animals that did not receive linamarin at both levels of dietary methionine. The plasma thiocyanate concentration was also higher for linamarin-fed animals than for animals that did not receive linamarin. Higher plasma thiocyanate levels were associated with a lower percentage uptake of radioiodine by the thyroid.

Animals↗
PubMedDate not supplied

Influence of dose level and methionine intake on the effects of linamarin administration to rats.

Rats were fed a semipurified diet providing 10% casein supplemented with methionine for 2 wk, at which time some animals received the same diet without the methionine for 4 d. Animals that received linamarin were given a single oral dose containing 500 or 250 mg per kilogram of body weight. At the higher linamarin dose all animals died within 5 h after dosing. Biochemical and physiological changes observed in these rats included severe metabolic acidosis, decreased cytochrome oxidase activities, atrial fibrillation, and decreased respiratory rates. In general, the cardiac adenosinetriphosphatase enzymes were inhibited by linamarin. None of these changes were moderated by dietary methionine supplementation. At the lower linamarin dose dietary supplementation with methionine appeared to reduce incidences of clinical toxicity signs and fatalities. No methionine effect was observed in the other biochemical and physiological measurements in rats given this amount of linamarin. The results suggest that dietary supplementation with methionine provided some protection against the toxicity of the lower level of linamarin administered.

Adenosine Triphosphatases↗
PubMedDate not supplied

Right lower lobectomy for pulmonary infarction before orthotopic heart transplantation.

A 39-year-old potential heart transplant recipient had a right lower lobe infiltrate and on pulmonary angiography was found to have an embolous to the common basilar artery. This was successfully managed by a right lower lobectomy, after aggressive medical management failed. The patient was treated postoperatively with antibiotics and subsequently underwent orthotopic heart transplantation. At 1 year after transplant the patient has no evidence of cardiac or pulmonary insufficiency.

Adult↗