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Biomedical subjects

J C Addonizio

Publications and source records attributed to J C Addonizio.

51 records · Page 3Linked to original sources

Use of ultrasonic surgical aspirator in renal surgery.

The Cavitron ultrasonic surgical aspirator (CUSA) was used to fragment and aspirate normal and pathologic renal tissue. The operative blood loss utilizing the CUSA was markedly reduced compared to electrocautery or the cold scalpel. This is due to the ability of the instrument selectively to fragment and aspirate tissue with high-water content, such as renal parenchyma, while sparing tissue with higher elastin and collagen content, such as collecting system or blood vessel. The surgeon can therefore skeletonize and secure the blood vessels before they are divided.

Animals↗

Stab wounds of the kidney: conservative management in flank penetration.

Between April 1976 and December 1980, 373 patients with stab wounds of the abdomen were seen in our emergency room. Of 47 cases (12.6 per cent) in which renal penetration was confirmed nonoperative management was selected in 34 (70.2 per cent), with no further sequelae in 28 (82 per cent). The site of abdominal penetration was posterior to the anterior axillary line in 30 successful conservatively managed patients (88 per cent). The site of abdominal wound penetration in conjunction with clinical stability may avoid unnecessary renal explorations.

Humans↗

Depressed myocardial function after transurethral resection of prostate.

Cardiovascular physiologic monitoring was undertaken in 12 patients undergoing transurethral resection of the prostate with the aid of flow-directed Swan-Ganz catheter and the Automated Physiologic Profile. Cardiac and pulmonary pressures and physiologic parameters were derived pre- and postoperatively. Resecting time, body temperature, intravenous fluid administered, serum hemoglobin, and sodium also were recorded. Of the 12 patients studied, 66 per cent experienced a drop in their cardiac index as well as their left ventricular function after surgery. Myocardial function curves revealed that 7 patients (58 per cent) had decreased cardiac function, 2 had no change, and 3 had increased function. Four patients with preoperative pulmonary wedge pressures (PAW) over 9 mm. Hg experienced depressed cardiac function. Three patients were resected for over sixty minutes, and all experienced depressed cardiac function. Vital signs, serum hemoglobin, or serum sodium did not reflect this change. We believe that relative hypervolemia, undetected elevation of pulmonary wedge pressure. We believe that relative hypervolemia, undetected elevation of pulmonary wedge pressure, and prolonged resection are factors that depress cardiac function and increase the risk of cardiovascular complication in transurethral surgery.

Aged↗

Renal venography in diagnosis of infiltrating transitional cell carcinoma of renal pelvis.

Urologic evaluation of a ninety-two-year-old man with hematuria suggested lower segmental renal infarction on selective renal angiogram. Nonvisualization of the lower segmental venous tributaries and capillaries on renal venogram was consistent with the operative findings of microscopic infiltrating transitional cell carcinoma. The use of renal venography in these tumors is suggested.

Aged↗

Carcinosarcoma of prostate.

A case of carcinosarcoma of the prostate is described. Review of the literature revealed few cases, only 2 being well documented. The tumor presented as a urethral polypoid obstruction of the bladder neck and proved to involve bilaterally, the prostate and the seminal vesicles with metastases to the regional lymph nodes. Light microscopic findings are described as a multimorphic tumor with simultaneous presence of sarcoma, characteristically being malignant cartilage, rhabdomyosarcomatous component, and poorly differentiated carcinomatous areas. Controversy of this morphologic entity is discussed briefly. These tumors are highly anaplastic and rapidly fatal.

Adult↗

The MURCS association: Müllerian duct aplasia, renal aplasia, and cervicothoracic somite dysplasia.

Two patients and 28 others in the literature were ascertained because of congenital vaginal agenesis associated with clinical and/or radiographic evidence of malformations derived from the cervicothoracic somites. In these patients, there was a high incidence of Müllerian duct aplasia/hypoplasia (96%), renal agenesis and/or ectopy (80%), and abnormalities related to cervicothoracic somite dysplasia, particularly 2 to 4 anomalous vertebrae located between C5-T1 (80%). These consistent findings suggest a distinctive non-random association of malformations: Müllerian duct (MU) aplasia, renal (R) aplasia, and cervicothoracic somite (CS) dysplasia (MURCS). Identification of one component of the MURCS association suggests the presence of the other associated anomalies. A hypothesis for the embryogenic pathogenesis of the MURCS association is proposed which attributes the malformations to an alteration of the blastemas of the lower cervical-upper thoracic somites, arm buds, and pronephric ducts, all of which have an intimate spatial relationship at the end of the fourth week of fetal life. A presently unidentified teratogen may be one of the possible causes of the MURCS association on the basis of a lack of familial transmission, normal chromosomal studies, and the similar effects of a known teratogen (thalidomide) on the developing genitourinary tract.

Abnormalities, Multiple↗

Perineal seeding of prostatic carcinoma after needle biopsy.

The rarity of implantation of carcinoma of the prostate is generally accepted. In the last twenty years, there have been only 6 cases reported in the literature. We add a seventh case which is unique in that the seeding occurred after biopsy and intense radiotherapy was the only mode of treatment. We recommend that a sterilizing dose of radiotherapy be given to the perineum after perineal needle biopsy.

Adenocarcinoma↗