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Biomedical subjects

J Brune

Publications and source records attributed to J Brune.

At least 109 records · Page 6Linked to original sources
PubMed1982

[Perfusion and ventilation pulmonary scintigraphy in the diagnosis of the operability of primary bronchial cancers].

Ventilation scintigraphy using Munsch's technique with Xenon 133 combined with perfusion scintigraphy using 99m Tc albumin particles in microspheres are of considerable interest in the preoperative evaluation of bronchogenic carcinoma. Basing themselves on 95 cases, the authors discuss the manner in which the tumor affects ventilation and perfusion. In the 70 cases of matching ventilatory and perfusion scans, scintigraphy alone is not sufficient to demonstrate the exact perfusion obstruction mechanism. On the other hand, if there is a V/Q mismatch (21 cases) and if the perfusion defect is more extensive than the ventilation defect or the radiological opaque area, this normally implies a mediastinal extension of the tumor, and tends to make any carcinologically valid ablation highly risky. Comparison of the perfusion and ventilation scans with the radiological data and spirometric values showed that 9 patients presented with abnormal pulmonary radiographs outside the tumor areas. Six of these cases involved tuberculous sequelae. Forty-four of the ninety five patients (46.3%) showed normal ventilation and perfusion scans outside the tumor areas. Of the 91 patients undergoing spirometry, 39 suffered from ventilatory obstruction and pathological ventilation and perfusion scans and 18 presented with scintigraphic anomalies outside the tumor are a but did not suffer from ventilatory obstruction.

Adult↗
PubMed1981

[Respiratory complications in the course of treatment with D-penicillamine : alveolitis and bronchiolitis. A report of 4 cases (author's transl)].

D-penicillamine has proved to be an effective treatment of rheumatoid arthritis, but adverse effects of this drug are frequent. The authors report 4 cases of respiratory disease in the course of treatments with D-penicillamine for which the drug may probably be held responsible. Two patients presented with diffuse alveolitis which improved on stopping D-penicillamine. Two patients presented with rapidly progressive dyspnea; chest X-ray showed distended lungs; lung function tests showed severe airflow obstruction with air trapping : treatment with bronchodilators and corticosteroids was ineffective. Several cases of patients with such features have been reported during the last few years; pathologic studies which were performed disclosed bronchiolitis. Clinicians should be aware of the severity of this type of bronchiolitis and stop D-penicillamine immediately in patients presenting with early respiratory symptoms.

Aged↗
PubMed1980

[Intrathoracic splenosis. Apropos of a case].

The authors report an exceptional case of intrathoracic splenosis in a 34 year old woman suffering from a circulation injury with rupture of the spleen and left diaphragm and hemothorax. She had been splenectomized. Eleven years later, a systematic thoracic X-ray examination revealed a rounded opacity of the left extremity. Exeresis of a lump the size of a nut located in the pleural space without individualized vascular pedicle was performed. The lesion showed macroscopic and microscopic characteristics of splenic tissue. If peritoneal splenosis is more frequent, intrathoracic splenosis is exceptional (only 7 observations known). Every time, a traumatic splenic antecedent has been noted. The etiopathogeny consists of an autograft of splenic tissue most often in the pleural cavity, when a diaphragmatic lesion has been associated to the injury. The lesion is asymptomatic and does not provoke complication in that area. Histologically, the splenic parenchyma can be normal or limited to the red pulp with a more or less important degree of white pulp. The histological differences with the normal or accessory spleen are the non contractile collagenous texture of the capsular and the septa and the absence of hila. One should consider this etiology when antecedents of splenic and diaphragmatic traumatism are noted. Hepato-splenic scintigraphy can be useful in the diagnosis and help to avoid thoracotomy.

Adult↗
PubMed1979

Elevated serum beta 2-microglobulin levels and C1q-binding immune complexes in sarcoidosis.

Serum beta 2 microglobulin levels were found significantly higher (3.05 +/- 0.98 mg/l) in 32 sarcoidosis patients without renal dysfunction than in normal controls (1.54 +/- 0.22 mg/l). Low levels of C1q-binding immune complexes were detected in 70% of patient's sera, despite the absence of extra-thoracic manifestations. C-reactive protein was detected in 55% of sarcoidosis sera. Neither C1q-binding immune complexes nor C-reactive protein were correlated with beta 2 microglobulin levels. Beta 2 microglobulin raised during relapses and fell under efficient corticosteroid treatment. Beta 2 microglobulin would represent a possible biological marker of disease activity.

Adolescent↗
PubMed1978

["Small cell" carcinoma of the lung. Results obtained using combination chemotherapy (adriamycin, vincristine, cyclophosphamide) in 38 patients (author's transl)].

A cyclic and sequential combination of adriamycin, vincristine (or VM 26) and cyclophosphamide was used, with a follow up of 4 to 33 months in 38 patients with a "micro-cellular" carcinoma of the lung. Radiotherapy was used in association in a variable manner. Chemotherapy alone resulted in marked regression of the lesions (regression is greater than 50%) in approximately 65 per cent of cases and a level of complete regression which varied from 31 to 45 per cent according to the degree of diffusion of the lesions at the time of admission. In this study, survival in apparently localised forms was 70 per cent after one year and 55 per cent at eighteen months, whilst it was 34 per cent at one year and nil at eighteen months in patients with evidence of metastatic disease at the time of entry. These encouraging results indicate a hope for improvement, in certain patients reacting favourably to this protocol, in the still grave prognosis of "small cell" carcinoma of the lung.

Adult↗
PubMed1978

[The humoral immune response in recent pulmonary tuberculosis (author's transl)].

The average serum concentration of immunoglobulins, alpha-1-antitrypsin, haptoglobin and alpha-2-macroglobulin, calculated in 45 adults with pulmonary tuberculosis increased in a variable way for each of the six parameters studied. Tuberculosis does not induce new correlations between the parameters but modifies the intensity of existing links.

Adult↗
PubMed1977

[Treatment of agammaglobulinemia in the adult; report of 9 cases].

The study of 9 cases of agammaglobulinemia in the adult shows the classical symptomatology of these diseases. The evolutive study deals with too small a series to demonstrate statistically the superiority of the substitutive treatment over a simple chemo-therapeutic prevention of the infection, but nevertheless it shows : 1) that prognosis is bad only in cases of gross anatomical and physiological alterations and when they are the sole responsible for a fatal evolution; 2) that the substitutive treatment is only really efficient when given at high doses; the minimum dose of 250 mg per day seems advisable.

Adolescent↗
PubMed1977

[Study of various serum proteins in lung cancer. Immunoglobulins A, G, M, haptoglobin, alpha-1-antitrypsin, alpha-2-macroglobulin].

A statistical study of the plasma concentration of immunoglobulin, alpha-1-antitrypsin, haptoglobin, and alpha-2-macroglobulin in 153 patients with primary carcinoma of the lung showed a strong increase in alpha-1-antitrypsin, haptoglobin and A and C immunoglobulins, whilst alpha-2-macroglobulin increases very moderately, and IgM does not vary. The relationships between variables are also modified, thus there appears a correlation between IgA and IgG to the detriment of the IgG/IgM relationship. Furthermore the coefficient of the correlation IgG/alpha-2-macroblobulin is lower in cancer patients.

Female↗