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Biomedical subjects

J Brundin

Publications and source records attributed to J Brundin.

At least 37 records · Page 2Linked to original sources
PubMed1986

Thyroxine-binding globulin in spontaneous abortion.

Thyroxine-binding globulin (TBG), thyroxine-binding prealbumin (TBPA), thyroxine (T4), free T4, triiodothyronine (T3) and thyroid-stimulating hormone (TSH) were studied in 144 apparently healthy, euthyroid pregnant women displaying miscarriages. In an additional group of 18 aborting women a frozen blood sample drawn in early pregnancy was similarly analyzed for the thyroid components as well as for human chorionic gonadotropin (HCG). The values were compared to those of normal pregnancies (n = 228) at corresponding intervals. Significantly lower values of TBG were found in the spontaneously aborting group. A significantly lower value of TBG was found to be more predictive concerning spontaneous abortion than that of HCG.

Abortion, Spontaneous↗
PubMed1985

Long-term toxicity of a hydrogelic occlusive device in the isthmus of the human oviduct. A light microscopic study.

Ten women applying for sterilization volunteered for a tubal blocking procedure. An occlusive device of gamma polymerized hydrogel, a P-block, was applied in the isthmic part of the oviduct by trans-cervical hysteroscopy. Bilateral expulsion occurred in three and unilateral in six subjects. Six patients became pregnant. The P-block was in position from one week to 32 months. Histologically, the reaction to the P-block was first erosion and acute unspecific inflammation. Later there was a histiocytic and foreign-body reaction due to dissolution of the hydrogel. When the P-block was expelled no changes were present in the material.

Animals↗
PubMed1985

Doxycycline in human oviduct mucosa and plasma 24-30 hours after an oral dose of 100 mg.

Oviductal and peripheral plasma concentrations 24 hours after the last dose of Doxycycline (DC) were studied in 17 patients. The concentration of DC in healthy oviduct mucosa was 1.3 micrograms/g (range 0.6-1.7) and 1.1 micrograms/ml (range 0.6-1.7) in plasma. One patient with severe chronic salpingitis in acute exacerbation showed 3.6 micrograms/g in tissue and 2.4 micrograms/ml in plasma in proliferative phase.

Adult↗
PubMed1983

The A-rod--a new possibility for cervical dilation and/or induction of uterine contractions for abortion or delivery by combined pharmacological and mechanical action.

A hydrogel compound (Sauflex, Special Polymers Ltd., London) which has the capacity to swell by absorbing surrounding fluid, was found to be capable of absorbing prostaglandins (PGE1, PGF2 alpha) in alcohol or saline during this process. After evaporation of the hydratized hydrogelic compound which restored its initial proportions and stiffness, rehydratization of the hydrogelic compound caused it to release the respective prostaglandin to the surrounding medium or tissues. The endocervical canal of first-trimester abortions was dilated by plain mechanical action of a rod-shaped hydrogel body (A-rod) inserted in the cervical canal. By loading the A-rod with PGF2 alpha (2-110 mg) the cervical canal was additionally widened and abortive contractions were elicited in the uterus. Further implications of the medical use of the A-rod are discussed.

Abortion, Induced↗
PubMed1983

Levels of ampicillin and doxycycline in human oviduct mucosa and serum.

A common treatment for salpingitis today includes ampicillin (AMPI) and doxycycline (DC), the former against Neisseria gonorrhoeae and the latter against Chlamydia trachomatis. The concentrations of doxycycline in oviduct mucosa were found about equal to that of serum and well above the minimum inhibitory concentrations (MIC's) for the bacteriae in question. The concentration of AMPI in the oviduct mucosa was only about 1/40 of that in serum, i.e. 1/10 of the MIC, which jeopardizes the effectivity of AMPI in the treatment of salpingitis.

Adult↗
PubMed1982

Sex-dependent induction of human suppressor T cells by chorionic gonadotropin.

Human chorionic gonadotropin (hCG) in physiological retroplacental concentration has been shown to induce human female lymphocytes which suppress the proliferation and differentiation of B cells stimulated by purified protein derivative of tuberculin. To test whether the hCG-induced suppression was sex dependent parallel experiments using female and male peripheral lymphocytes were performed. hCG did not induce cells capable of suppressing purified protein derivative induced B cell proliferation in lymphocytes from males, which was in contrast to lymphocytes from females where a statistically significant suppression was found. A similar hCG-induced suppressive effect was found before menarche, after the menopause and in two patients with Turner's syndrome, suggesting that a gene(s) on the Y chromosome exerts a regulatory function and thus prevents the hormone from inducing suppressor T cells.

Aging↗
PubMed1982

Thyroid associated components in serum during normal pregnancy.

Thyroxine-binding globulin (TBG(, thyroxine-binding pre-albumin (TBPA), thyroxine (T4), free-T4, triiodothyronine (T3), and thyroid-stimulating hormone (TSH) were studied throughout apparently normal pregnancy in 290 cases grouped in 2 week intervals. TBG increased to a plateau level reached in the 24th week and was hereafter unchanged until term. T4 showed an increase until the 16th week of pregnancy and levelled off to a constant level for the rest of the pregnancy. Free-T4 declined to almost subnormal values for the non-pregnancy state which was reached around the 20th week of pregnancy. T3 showed a slight and definite increase in the beginning of pregnancy and levelled off to a constant value after the 14th week. TSH increased towards the end of pregnancy also showing its maximum during the last 4 weeks. TBPA showed constant values throughout pregnancy. The results are discussed in view of the use of modern techniques and previously missing data in literature (TBPA).

Female↗
PubMed1982

Levels of trimethoprim and sulfamethoxazole in human oviduct mucosa and plasma.

The oviductal and plasma levels of trimethoprim (TMP) and sulfamethoxazole (SMZ) were studied in 9 women after oral and i.v. administration of a drug combination (Eusaprim R, Wellcome Foundation Ltd). The concentration of TMP in a healthy endosalpinx was found to be twice as high (4.7 microgram/g, range 2.8-8.3) as in plasma (2.6 microgram/ml, range 2.1-3.6). Conversely, the endosalpingeal level of SMZ (38 microgram/g, range 12-65) was about half that in plasma (77 microgram/ml, range 58-95). The agar well diffusion method was used for the concentration determinations. The specimens were collected during surgery for non-infectious genital diseases. The implication of treatment by the given drugs is discussed.

Drug Combinations↗
PubMed1981

In vitro induction of human suppressor T cells by a chorionic gonadotropin preparation.

Human chorionic gonadotropin (hCG) in physiological retroplacental concentration has been shown to possess the capacity of inducing human lymphocytes which are subsequently competent to depress an antibody response induced by purified protein derivative of tuberculin, phytohemagglutinin, lipopolysaccharide and pokeweed mitogen. These suppressor cells inhibited the T cell-dependent mitogen-induced activation of lymphocytes synthesizing IgM, IgG and IgA. No suppression by hCG-induced cells was observed in Epstein-Barr virus activated cell cultures, indicating a T cell origin of the target cell. It is suggested that this may represent a mechanism for the cellular basis of an hCG-induced immunosuppressive effect in pregnancy.

Adult↗
PubMed1980

In vitro induction of murine suppressor T-cells by human chorionic gonadotropin.

Human chorionic gonadotropin (HCG) has previously been considered to be immunosuppressive and, thus, by prohibiting maternal rejection of the fetal transplant, to be one of the factors responsible for the successful outcome of pregnancy. The mechanism by which HCG exerts its pregnancy retaining effect is, however, as yet unknown. The present study shows that HCG has the capacity in mice of inducing lymphocytes which are subsequently competent to depress a polyclonal antibody response induced by different B cell mitogens. It is therefore suggested that HCG may exert its feto-protective action by inducing suppressor T cells. These lymphocytes would thus prevent the activation of cells which are responsible for transplant rejection.

Animals↗
PubMed1977

Frequency-dependence of 3H-noradrenaline secretion from human vasoconstrictor nerves: modification by factors interfering with alpha-or beta-adrenoceptor or prostaglandin E2 mediated control.

Isolated superfused field stimulated human omental arteries and veins, preincubated with 3H (-)-noradrenaline (NA) were used to study the frequency dependence of NA secretion and of the mechanisms for its local feedback control. 3H-NA secretion per shock was found to be basically a simple hyperbolic function of the stimulation frequency from 1 to 30 Hz, as long as secretion was restricted by prostaglandin E2 (PGE2). In the absence of restriction, or during facilitation, 3H-NA secretion per shock reached its maximum at 10 Hz and then declined at 30 Hz, indicating 'overload' in some link in the secretory mechanism. 3H-NA secretion was depressed by exogenous NA and by PGE2, and enchanced by isoprenaline, phentolamine and by blockade of PGE2 formation. Most of these effects were inversely related to the stimulation frequency. Attempts were made to study interactions between the different control mechanisms and to evaluate possible in vivo consequences of disturbance of adrenergic neuroeffector transmission by interference with the local control of the secretory mechanisms.

Adolescent↗
PubMed1977

Changes of bone mineral content during pregnancy and lactation.

In order to study changes in the calcium depots of the body during pregnancy and lactation, bone mineral deteminations were performed on fourteen pregnant women and eighteen mothers post partum by X-ray spectrophotomeyry. Pregnant women exhibited a loss in trabecular bone but not in cortical bone when measured once during late first or early second trimester and again one week post partum. Lactating women who nursed less than three months lost mineral during the first three months and than regained it while those who nursed for longer than three months had no losses during six months of study.

Adult↗
PubMed1976

Ultrastructure of the nerves in veins from human omentum.

To study the ultrastructural characteristics of the sympathetic nerve terminals of human omental veins, and of their relationship to the innervated smooth muscle cells, biopsy specimens were taken during abdominal surgery, rapidly fixed in glutaraldehyde/osmium and stained with uranylacetate. The results indicate that the veins have an extensive noradrenergic innervation, penetrating into the tunica media. The distance between nerve terminals partly or wholly free from enveloping Schwann cells, to the surface of smooth muscle cells ranged from 30 to 500 nm. Large dense core vesicles were prominent in both preterminals and terminal regions, while small dense core vesicles occurred mainly in terminals. Large dense core vesicles in close contact with the axolemma were occasionally observed, indicating involvement in secretion by exocytosis.

Chromaffin Cells↗