Biomedical subjects

J Brozek

Publications and source records attributed to J Brozek.

At least 19 recordsLinked to original sources

PubMed2001

Treatment with simvastatin and low-dose aspirin depresses thrombin generation in patients with coronary heart disease and borderline-high cholesterol levels.

Aspirin and statins are beneficial in coronary heart disease across a broad range of cholesterol levels. We assessed the effects of low-dose aspirin (75 mg daily) on thrombin generation in patients with coronary heart disease and average blood cholesterol levels. We also investigated whether in patients with borderline-high cholesterol level who have been already taking aspirin, additional treatment with simvastatin would affect thrombin generation. Seven-day treatment with low-dose aspirin decreased thrombin generation ex vivo only in patients with total cholesterol < or = 5.2 mmol/L. In patients with higher cholesterol levels aspirin had no effect. In these patients, already taking low-dose aspirin, additional three-month simvastatin treatment resulted in a reduction of thrombin generation. This demonstrates that low-dose aspirin depresses thrombin generation only in subjects with desirable blood cholesterol levels, while in others, with borderline-high cholesterol, thrombin formation is being reduced following the addition of simvastatin.

Adult↗

PubMed1998

[Acute leukemia in children with Down syndrome: analysis of cases].

An analysis of clinical and laboratory parameters and the results of treatment of 14 children with Down Syndrome and acute leukaemia was performed. The children were treated between 1986-1997. Their age ranged from 1 day to 13 years (average 5.5). There were 9 girls and 5 boys. Four of them had congenital heart disease. ALL was observed in 10, AML in 3 and TAM (Transient Abnormal Myelopoesis) in 1. Half of the children with ALL was classified as L1 according to FAB with the majority of common phenotypes and M6 in ANLL group. Remission was achieved in all ALL patients, six of them are still free of symptoms, the remaining four died of brain haemorrhage as a consequence of myelosuppression. Only 1 of 3 children with ANLL achieved remission. The child died of cardiac arrest after induction phase of BFM 95 programme (ADE). The 2 remaining children with ANLL also died of circulation failure before initiation of chemotherapy. The children had complicated cyanotic heart disease. The neonate with TAM is in clinical and hematological remission. In conclusion all children with ALL achieved hematological remission but tolerance of treatment was a problem. The majority of patients had diminished bone marrow reserve. Mortality was frequently related to circulatory failure in children with associated heart defects. It seems necessary to discuss the modification of accepted programmes for leukemia for the treatment of children with Down Syndrome.

Adolescent↗

PubMed1995

Bibliographical note on behavioral aspects: on the margin of the 50th anniversary of the Minnesota Starvation-Nutritional Rehabilitation experiment.

The principal technical aim of this note is to bring together bibliographic information on the papers dealing with the behavioral aspects of the study and published both before and, in particular, after the appearance in print of the two-volume treatise on The Biology of Human Starvation by Keys, et al. in 1950, which provides a systematic, comprehensive account. The communications fall into three categories: methods, results, and overviews. The section on results is concerned primarily with the effects on personality.

Anniversaries and Special Events↗

PubMed1991

Contributions to the history of psychology: LXXXIII. J.E. Purkinje and Mathias Klotz: who first described "the phenomenon"?

In 1825 Purkinje described the effects of increasing ambient illumination at early dawn, beginning with darkness, on the perception of spectral colors. The blues were seen first. When reds became visible, they appeared less bright than the blues. The usually dependable Brockhaus Encyclopedia stated (1972) that the phenomenon was described in 1816 by Mathias Klotz and rediscovered ("erneut entdeckt") by Purkinje. As it turns out, Klotz correctly described the effects of low ambient illumination on the relative brightness but his report on visibility contradicts Purkinje's observations, amply confirmed by subsequent investigators and known, in fact, prior to Purkinje's report.

Color Perception↗

PubMed1990

Contributions to the history of psychology: LXXI. "Purkinje phenomenon": the genesis and the early uses of the term in French, German, and English.

In an earlier note (Brozek, 1989) regret was expressed that Zusne's valuable book Eponyms in Psychology (1987) did not provide information on persons who coined the eponyms as well as on the time and place in which they were introduced into the scientific literature. The present report provides such information for the term "Purkinje phenomenon." In French it was used by J. Macé de Lepinay and W. Nicati in 1882, in Germany by Ewald Hering in 1895, and in English by J. B. Haycraft in 1897.

Color Perception↗

PubMed1990

Psychological abstracts and German-language psychology.

The preparation of the present report was motivated by concern over the continuing reduction of the coverage of psychological materials published in German, and a complete cessation of the coverage in Psychological Abstracts (PA) in 1988. This report covers the following points: (1) The share of German Psychologists in the prehistory of PA; (2) Membership in the editorial board of PA; (3) Cessation of the coverage of books in PA; (4) German-language materials abstracted in PA; and (5) German-language materials in the database of the American Psychological Association in the years 1987-1989. Two addenda inform about citation of (6) German-language publications in early American journals and (7) the changing role of the German Journal of Psychology.

Germany↗

PubMed1989

Contributions to the history of psychology: LVI. J.E. Purkinje (1787-1869), "the phenomenon" and beyond.

Light-adaptation and dark-adaptation are complementary (not "identical") processes. Both came to be covered by the term "Purkinje phenomenon." While the phenomenology remains unaffected by the advances of science, our understanding of the histological details and the molecular events has increased dramatically. At the same time we are still in the dark as to who coined the term "Purkinje phenomenon" and what relevant observations preceded Purkinje's report of 1825. A comprehensive account of Purkinje's involvement in psychology and its significance is lacking.

Czechoslovakia↗

PubMed1982

Robert I. Watson and the development of the history of psychology: a symposium

Explore the source record for details and available documents.

Academies and Institutes↗

PubMed1982

Blood lipids in young men followed 32 years.

The relationship of baseline characteristics to serum cholesterol at baseline (CHL47) when aged 16-25 (mean 20.5) yr and at 32-yr follow-up (CHL79) was assessed in 162 men. Mean CHL rose over the follow-up period. CHL47 predicted CHL79 (r = 0.61, p less than 0.001) but not CHL79-CHL47. The mean (+/- SD) weight change (DW) was 12.0 kg (+/- 26.0 kg). DW was not significantly related to CHL47, but was independently related to CHL79-CHL47 (4 = 0.30, p less than 0.001). Age, height, DW, any of 7 measures of baseline obesity and CHL47 predicted CHL79 with R2 of 0.40 and CHL79-CHL47 with R2 of 0.37. Thus, weight change but not baseline relative weight was a determinant of serum cholesterol change from youth to middle age. There was strong tracking of serum cholesterol over this period.

Adult↗

PubMed1982

Indices of obesity and blood pressure in young men followed 32 years.

In order to assess the effects of baseline indices of obesity, lean body mass, blood pressure, and weight change on future blood pressure, 112 former college men were examined 20 and 32 years after initial examination at age 20.5 (+/- 2) yr. Baseline body weight, relative body weight, body mass index and body density all showed similar significant correlations with baseline systolic blood pressure (r = 0.35, 0.31, 0.30 - 0.31) but not baseline diastolic blood pressure (r = 0.13, 0.07, 0.10 - 0.11) or follow-up blood pressure. Changes in body weight, relative body weight, body mass index and sum of skinfolds were significantly correlated with change in both systolic and diastolic blood pressure. Baseline systolic blood pressure was the most powerful predictor of 20- and 32-yr follow-up systolic (r = 0.57, 0.42), but baseline diastolic was a much weaker correlate of follow-up diastolic blood pressure (r = 0.24, 0.18).

Adolescent↗

PubMed1981