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Biomedical subjects

J Brossmann

Publications and source records attributed to J Brossmann.

At least 73 records · Page 4Linked to original sources

Arthrographic effect induced by therapeutic ultrasound in magnetic resonance imaging of the wrist: a preliminary investigation.

OBJECTIVE: To evaluate the potential arthrographic effect of therapeutic ultrasound applied before magnetic resonance imaging (MRI) of the wrist. SUBJECTS AND METHODS: MRI of the wrist was performed in 6 asymptomatic volunteers before and after ultrasound therapy of the carpus. For each patient, ultrasound therapy was performed by a trained physiotherapist for 10 minutes, with doses titrated to the maximum tolerated without pain. The amount of fluid within the wrist joints before and after therapy was assessed subjectively by 2 reviewers, as well as objectively by digital analysis. RESULTS: Subjective appraisal of the images indicated that after ultrasound therapy there was an increase in joint fluid within the distal radioulnar joint in 4 volunteers, the midcarpal joint in 4 and the radiocarpal joint in 2. Computerized digital analysis of joint fluid confirmed an average volumetric increase in wrist joint fluid of 52.8% in 3 of the volunteers. The discomfort of the therapy was graded as 1/10 by 5 of the subjects and 4/10 by a single subject. CONCLUSIONS: Therapeutic ultrasound may be a useful adjuvant tool in the noninvasive induction of joint fluid before MRI of the wrist.

Adult↗

[Therapy of venous stenosis using wall stents].

OBJECTIVE: To evaluate the patency of Wallstents implanted for the treatment of venous stenoses in patients with benign or malignant disease. PATIENTS AND METHODS: 22 Wallstents (20 central venous; two peripheral) were implanted during a period of two years in 12 patients (nine men, three women; mean age 57.8 [26-76] years) with malignant venous stenoses (n = 9) or stenosed dialysis shunts (n = 3). Stent diameter ranged from 8-16 mm, length from 32-91 mm. Introduction of the stents were by percutaneous transfemoral catheterisation, in six patients with simultaneous wire placement from a cubital to the femoral vein. The superior vena cava was the involved vessel in six patients (in two each also the subclavian or brachiocephalic veins), in three only the subclavian vein, twice only the inferior vena cava and once the cephalic vein. RESULTS: The patency of the stents was checked after 4.7 +/- 3.6 (1-14) months, in seven patients clinically, by digital subtraction phlebography in three, by computed tomography in two. In nine patients there was no evidence of obstruction to flow or flow was normal. Stent occlusion had occurred in three patients, 4, 9 and 14 months after placement. There were no complications. Five patients died after a mean period of 4.8 +/- 3.6 (1-6.5) months from the underlying disease, without symptoms of obstruction to flow. CONCLUSION: Stent placement should be considered early, as it is a well-tolerated and effective palliative procedure for central venous stenoses associated with malignant disease or stenosis of dialysis shunts.

Adult↗

Influence of different fasting periods on P-31-MR-spectroscopy of the liver in normals and patients with liver metastases.

The purpose of this study was to determine the influence of different fasting periods on the in vivo P-31-MR spectroscopy of the healthy liver and patients with liver metastases. Image-guided localized P-31-MRS was performed in 24 patients with liver metastases and in 20 healthy volunteers. The spectra were obtained with a whole body scanner operating at 1.5 T using a surface coil. The P-31-MRS was performed after a fasting period of 3-5 h (group 1) and after overnight fasting (group 2). The PME/beta-NTP, PDE/beta-NTP and Pi/beta-NTP were calculated from P-31-MR spectra and were compared in relation to the nutrition status of the volunteers and patients. The PME/beta-NTP and PDE/beta-NTP were significantly increased in spectra of patients with metastases. There were no significant changes in the ratios of phosphorus metabolites in healthy liver tissue or in liver metastases after a fasting period of 3-5 h as compared with overnight fasting.

Adult↗

Osteoarthritis.

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Humans↗

[MR angiography in fibromuscular dysplasia of the cervical arteries].

PURPOSE: To determine 3-D time of flight MR angiography for evaluation of fibromuscular dysplasia in cervical vessels. MATERIAL AND METHODS: In 386 selective angiograms of cervical vessels fibromuscular dysplasia was revealed in 4 female patients in the age of 30-54 years. FMD was located in the carotid artery (n = 5) and in the vertebral artery (n = 2) with a total of 8 lesions. RESULTS: 6/8 of the lesions of the seven cervical vessels were located typically in the mid cervical portion of the vessels and 2/6 lesions were located in the atlas loop of the vertebral artery. 4 lesions showed moderate stenosis and 4 vessels showed only mild stenosis. These patterns which demonstrated the typical morphology of fibromuscular dysplasia with alternating irregular zones of widening and narrowing were evaluated well with MR angiography, the others were missed. CONCLUSION: MR angiography is suitable for detection of fibromuscular dysplasia when the characteristic pattern is combined with moderate stenosis of the vessel. Conventional angiography remains the standard of reference.

Adult↗

[Technical modification of the rheolytic thrombectomy].

A 48-year-old male patient with acute occlusion (5 cm) of a leg artery was treated with the rheolytic thrombectomy (RT). As recommended the catheter is applied via a single coaxial running guide wire, which is removed later. If an additional wire has been placed in the occluded vessel segment, the occlusion can be passed repeatedly. A 30 degrees bent catheter tip improves the removal of wall-adherent thrombotic material. The occluded segment was successfully recanalized with the RTC, 270 ml of heparinised saline had been injected. The blood examinations showed mild haemolysis.

Arterial Occlusive Diseases↗

[Results of percutaneous implantation of coated vascular prostheses in long-distance femoropopliteal occlusions].

PURPOSE: Evaluation of primary patency rate, complications and midterm follow-up after implantation of endoprostheses in femoropopliteal occlusions. MATERIAL AND METHODS: 25 patients suffering from femoropopliteal occlusion (average length 7 cm) underwent percutaneous femoropopliteal endoprosthesis treatment. A total of 34 endoprostheses were implanted. Clinical and Doppler follow-up was performed after 1, 3, 6 and 9 months. Mean follow-up is 6 months. RESULTS: Percutaneous placement of endoprostheses was successful primarily in 24/25 patients. In one patient an early occlusion of the endoprosthesis occurred, caused by an embolic complication. Primary patency was 64% after 6 months and secondary patency rate was 71%. Severe local pain at the application site and fever was observed in 40% of the patients. CONCLUSION: The occlusion rate of 36% after 6 months is high. Long-term follow-up must be awaited before a general recommendation can be made. The cause of the local pain and fever in the early postinterventional period remains unclear.

Adult↗

[Modified manual rt-PA pulse-spray lysis in occlusions of leg arteries and femoro-popliteal bypasses].

PURPOSE: The evaluation of local rt-PA pulse-spray-lysis (PSL) by the Katzen infusion wire for treatment of thrombosed leg arteries and bypass grafts. MATERIAL AND METHOD: 21 patients (mean age 64.4 years) with either occluded leg arteries (n = 19) or femorocrural bypass grafts (n = 2) were treated with PSL. Mean length of occlusion was 13.2 +/- 11.6 cm. Time of occlusion ranged from less than one week to 6 months. RESULTS: In 71.43% (15/21) the occlusions could be successfully recanalized with PSL. The mean rt-PA dose was 10.7 +/- 4.9 mg. Remaining stenoses were handled with PTA (n = 9) and additional stent implantation (n = 3). Additional long-time-lysis with 17.5 mg rt-PA was necessary in two cases, the success rate increased to 81% (17/21). The anlde-brachial-index increased from 0.38 +/- 0.29 to 0.83 +/- 0.32 within 24 hours after intervention. In 4 cases bleeding complications occurred. 5 patients showed reocclusions during 6 months follow-up. CONCLUSIONS: Local fibrinolysis with rt-PA in PSL technique using the Katzen infusion wire is a feasible and promising treatment of thrombosed leg arteries and grafts. Even careful and dosage-minimized rt-PA application cannot prevent bleeding complications.

Adult↗

Effect of intraarticular pressure on patellar position. Computed tomography study in cadaveric specimens.

RATIONALE AND OBJECTIVES: The purpose of the study was to evaluate the effect of articular fluid distention on patellar position at different degrees of knee angulation. METHODS: Patellar position in 10 cadaveric knee specimens was determined with 30, 100, and 200 mm Hg joint distention at 45, 20, and 5 degrees of knee flexion using computed tomography. Patellar tilting and lateromedial and anteroposterior displacement of the patellar position were analyzed. RESULTS: Lateral tilting increased with greater articular distention and decreasing knee flexion. At 5 degrees of flexion and 200 mm Hg of distention, change in lateral tilting ranged from -7 to +5 degrees. At 45 degrees of flexion and increased distention, the patellar shift ranged from 6 mm medialization to 1 mm lateralization for 200 mm Hg, but the patellar position was more variable at 5 degrees of flexion with increasing intraarticular pressure (range 7 mm medialization to 8 mm lateralization). With increasing articular pressure the patellae were increasingly displaced anteriorly with the most pressure-dependent changes at 45 and 20 degrees of knee flexion. CONCLUSIONS: Fluid distentions of the knee joint have unpredictable and varying effects on the patellar position and vary considerably among persons. When judging patellar position during arthroscopy and in patients with large joint effusions, the arthroscopist and radiologist should be aware of these effects.

Aged↗

Coralline hydroxyapatite bone graft substitutes. Evaluation of bone density with dual energy x-ray absorptiometry.

RATIONALE AND OBJECTIVES: The authors evaluate whether dual-energy x-ray absorptiometry (DXA) is a reliable method to determine the density of natural coralline hydroxyapatite (HA) blocks used as bone graft substitutes. METHODS: To evaluate the basic density of HA blocks from the same coral heads with and without titanium meshes, densitometry of 12 HA-500 blocks (genus Goniopora) and 12 HA-200 blocks (genus Porites) was performed. In addition, density measurements of 30 HA blocks (HA-500, n = 15; HA-200, n = 15) from different coral heads were obtained to assess if the originating coral head influences the basic density of blocks within one coral genera. To assess standard deviation serial measurements on eight coralline HA blocks, four with titanium meshes and four without were performed. In the ex vivo study, densitometry of 12 HA blocks (HA-500, n = 4; HA-200, n = 8) used as bone graft substitutes in the mandibles and craniums of adult mongrel dogs was performed. Densities were measured after bone ingrowth for 2 and 4 months, respectively. All measurements were obtained with a Lunar DPX with scan mode "slow 750" in the spine program with the regions-of-interests selected manually. Bone ingrowth was assessed by computer-assisted histomorphometry, which was considered the gold standard. Statistical analysis was performed to correlate the densities of plain HA blocks with and without meshes to the specific weights of the blocks. RESULTS: Significant positive correlation was found between the density of each HA block (both coral species) with and without meshes and the calculated specific weights. Densitometry values showed no significant differences depending on the originating coral heads. Standard deviation ranged between +/- 3.8% and +/- 4.1% (HA-500) and between +/- 3.0% and +/- 3.8% (HA-200). Hydroxyapatite-500 blocks showed marked increased densities between 15% and 34% after 4 months in three specimens in which bone ingrowth between 16.9% and 21.1% was revealed by histomorphometry; no increase of density was observed in one specimen, which presented only minimal bone ingrowth and signs of infection. Despite bone invasion between 12% and 25.8%, no increased densities were observed for HA-200 implants. CONCLUSIONS: Dual-energy x-ray absorptiometry is an accurate and reproducible modality to assess the densities of plain coralline HA blocks and to monitor bone ingrowth into coralline HA-500 but not into HA-200 block implants.

Absorptiometry, Photon↗

Sternoclavicular joint: MR imaging--anatomic correlation.

PURPOSE: To correlate magnetic resonance (MR) images of the sternoclavicular joint with anatomic sections. MATERIALS AND METHODS: MR imaging was performed on 14 sternoclavicular joints in seven specimens from cadavers (three men and four women 64-94 years of age at death; mean, 84 years). MR arthrography was performed in four specimens (eight joints), after injection of gadopentetate dimeglumine. After imaging, the specimens were frozen and cut into 3-mm-thick slices along the MR imaging planes. Images were correlated with the anatomic slices. RESULTS: MR imaging depicted the anatomy of the sternoclavicular joint and surrounding soft tissue. T2-weighted and proton-density-weighted images were superior to T1-weighted images in depiction of the intraarticular disk. MR arthrography depicted best the intraarticular disk and four of five perforations and delineated the joint capsule. All perforations also were depicted on T2-weighted images. CONCLUSION: MR imaging allows delineation of all structures of the sternoclavicular joint. MR arthrography allows delineation of perforations of the intraarticular disk.

Aged↗

Enlargement of the third intercondylar tubercle of Parsons as a sign of osteoarthritis of the knee: a paleopathologic and radiographic study.

PURPOSE: To correlate presence and size of the third intercondylar tubercle of Parsons (TITP) with occurrence and severity of osteoarthritis of the knee. MATERIALS AND METHODS: In 100 paleopathologic tibial specimens and on 160 clinical knee radiographs, size of the TITP was correlated with osteoarthritis of medical and lateral femorotibial joints (FTJ) and with prominence of tibial spines. RESULTS: TITP size correlated significantly with osteoarthritis of the tibial plateau in the paleopathologic specimens (P<.0001). TITP size correlated significantly with osteoarthritis of medial FTJ and tibial spines on radiographs (P<.0001). Of 85 patients without osteoarthritis of the medial FTJ, 49 (58%) had no TITP, 33 (39%) had small TITPs, and three (4%) had medium or large TITPs. TITPs were found in 15 (88%) of 17 patients with pronounced osteoarthritis. CONCLUSION: Frequency and prominence of TITPs are increased in patients with osteoarthritis of the medial FTJ and prominent tibial spines. Prominent TITP is a secondary sign of osteoarthritis. At histologic examination, increasing size of TITPs represents osteophytosis or enthesopathy of the TITP.

Adolescent↗

Tarsometatarsal joint: anatomic details on MR images.

PURPOSE: To evaluate the diagnostic capabilities of magnetic resonance (MR) imaging in the tarsometatarsal ([TMT] Lisfranc) joint with close anatomic correlation. MATERIALS AND METHODS: Six normal cadaveric feet were imaged by using T1-weighted spin-echo (oblique axial) and three-dimensional spoiled gradient-recalled acquisition in the steady state ([SPGR] coronal, sagittal) sequences. Subsequently, gadolinium-enhanced arthrography was performed in three specimens followed by T1-weighted spin-echo and SPGR MR imaging. Specimens were sectioned in all three planes followed by correlation of the MR imaging results with gross anatomic findings. RESULTS: In all specimens, the oblique axial and, less effectively, the coronal and sagittal planes allowed visualization of the Lisfranc ligament. Intermetatarsal ligaments were seen almost exclusively on the coronal images, and TMT ligaments on the sagittal images. Bone alignment could be assessed on the oblique axial images. CONCLUSION: MR imaging reliably depicts the anatomy of the TMT joint including ligamentous and osseous structures.

Cadaver↗

Dacron-covered stent-grafts for the percutaneous treatment of carotid aneurysms: effectiveness and biocompatibility--experimental study in swine.

PURPOSE: To evaluate the short-term effectiveness and biocompatibility of Dacron-covered stent-grafts for percutaneous treatment of carotid aneurysms. MATERIALS AND METHODS: In eight swine, nine aneurysms were created surgically in the common carotid artery. Percutaneous treatment was performed with Dacron-covered stent-grafts. Seven of eight swine underwent follow-up angiography at 2, 3, 4, and 5 weeks after stent implantation. Histologic examinations of tissue from the site of stent implantation were performed at the same intervals. RESULTS: Initial closing off of the aneurysm was possible in all swine. Angiographic follow-up revealed patency of only one Dacron-covered stent-graft after 2 weeks. In six of seven swine, the stent was occluded on the follow-up angiogram. One of the swine died of unclear cause after 1 week. The stent-graft of this swine was not occluded. In all Dacron-covered stent-grafts, inflammatory reaction with granulocyte infiltration was found next to the Dacron material. CONCLUSION: Primary treatment of carotid aneurysms with Dacron-covered stent-grafts is effective. However, the short-term patency rate is poor, which probably can be attributed to the limited biocompatibility of the Dacron cover. An acute inflammatory reaction against Dacron seems responsible for the poor patency rate.

Angiography, Digital Subtraction↗

Imaging of osseous and cartilaginous intraarticular bodies in the knee: comparison of MR imaging and MR arthrography with CT and CT arthrography in cadavers.

PURPOSE: To compare magnetic resonance (MR) imaging and MR arthrography with computed tomography (CT) and CT arthrography in the detection of intraarticular bodies in the knee. MATERIALS AND METHODS: Cuboid (3- or 6-mm-long sides) osseous and cartilaginous bodies were implanted in 16 cadaveric knee specimens. MR imaging was performed with T1-weighted spin-echo (SE), T2-weighted SE, proton-density-weighted SE, gradient recalled acquisition in the steady state (GRASS), and spoiled GRASS sequences. MR arthrography was performed in two phases with saline and 2 mmol/L gadopentetate dimeglumine. CT and CT arthrography were performed in the transaxial plane. RESULTS: MR arthrography yielded the highest accuracy for the detection of osseous and cartilaginous bodies combined (92%) and was significantly (P < .01) better than MR imaging (57%-70%), CT arthrography (80%), and CT (74%). Accuracy of CT arthrography was significantly better than that of MR imaging and that of CT. Accuracy of saline-enhanced MR arthrography was significantly inferior (P < .001) to that of gadolinium-enhanced MR arthrography. CONCLUSION: MR arthrography is the best imaging technique for detection of individual intraarticular bodies. CT arthrography is the second most accurate method. Spoiled GRASS and T2-weighted SE sequences are the most accurate at MR imaging. The presence of intraarticular fluid and performance of saline-enhanced MR arthrography improve detectability of intraarticular bodies.

Arthrography↗

MR imaging of the tarsometatarsal joint: analysis of injuries in 11 patients.

OBJECTIVE: We evaluated how well MR imaging revealed ligamentous and bony abnormalities in patients with injuries of Lisfranc's joint. SUBJECTS AND METHODS: We evaluated the studies of 11 patients with plantar hyperflexion injuries of the foot who underwent MR imaging in all three planes using spinecho T1-weighted, fast spin-echo T2-weighted, and short inversion time inversion recovery sequences. In four of the 11 patients, a three-dimensional spoiled gradient-recalled acquisition in the steady-state volume sequence was performed in the coronal plane. For five of the 11 patients, radiographs were available for evaluation. RESULTS: Radiographs revealed tarsometatarsal joint malalignment in all five patients for whom plain films were available, metatarsal fractures in four of these patients, and tarsal fractures in the same four patients. MR imaging showed joint malalignment in all 11 patients and disruption of the Lisfranc's ligament in eight of the 11 patients. In the remaining three patients, normal Lisfranc's ligaments were associated with avulsion fractures of the second metatarsal bases or the medial cuneiform bones. On MR imaging, fractures of the metatarsal bases were evident in 10 of 11 patients. Fractures of the tarsal bones were seen in the same 10 patients. CONCLUSION: MR imaging allows the detection of disruption of the Lisfranc's ligament as well as tarsal and metatarsal fractures and therefore may be a valuable technique in assessing patients after trauma to the tarsometatarsal joints when results of routine radiographs are not conclusive.

Adult↗