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Biomedical subjects

J Brooks

Publications and source records attributed to J Brooks.

168 records · Page 10Linked to original sources
PubMedDate not supplied

Venous leg ulcers: the role of the GP and district nurse.

AIM: To identify the healing rates for patients with venous leg ulcers (VLUs) who are nursed by district nurses. METHOD: The researchers performed a retrospective chart review of patients treated for VLU disease by district nurses to determine the healing rate, time to heal and variables associated with diagnosis. Forty random charts were abstracted from seven surgeries in Oxfordshire. RESULTS: Forty per cent of patients healed in less than 12 weeks and a further 42.5 per cent healed in 6.5 months. Some trusts and GPs lack understanding of what the district nursing service can offer patients with VLUs. CONCLUSION: If district nurses work collaboratively with GPs, either in the home or in a weekly clinic, they can provide good care to patients with VLUs.

Aged↗
PubMedDate not supplied

A pilot study with long term follow up of hyperbaric oxygen pretreatment in patients with locally advanced breast cancer undergoing neo-adjuvant chemotherapy.

Work in an animal cancer model suggests that pretreatment with hyperbaric oxygen can improve tumor vascularity rendering chemotherapy more effective. Accordingly 32 subjects with locally advanced breast carcinoma (>5cm diameter) entered into a randomized clinical trial where a course was administered of six intravenous pulses of cyclophosphamide 1000mg/m2 i.v., doxorubicin 50mg/m2 i.v. and vincristine 1.5mg/m2 i.v. In the case group this was preceded by ten, once daily, sessions of hyperbaric oxygen therapy (HBO2) administered either at 2.4 or 2.0 atmospheres absolute. Eleven out of 15 subjects tolerated a full course of HBO2 and chemotherapy. All 17 control subjects tolerated a full course of chemotherapy. Tumor extravascular extracellular or edema fluid was reduced after HBO2 but there was no reduction in tumor cell volume and no indication of increased vascularity on MRI. Clinical and pathological responses to chemotherapy were the same in both groups and there was no evidence of neovascularisation. Five year survival in those who tolerated the trial regime was 73% and did not differ between the groups. This mortality was cancer related.

Adult↗