Search PubMed⌕ Search

Biomedical subjects

J Brooking

Publications and source records attributed to J Brooking.

15 recordsLinked to original sources
PubMed2001

Transport of nanoparticles across the rat nasal mucosa.

The transport of 125I-radiolabelled latex nanoparticles across the nasal mucosa of rats was studied using a range of particle sizes and surface coatings. Translocation of the particles into the blood stream was examined by means of monitoring the radiolabel associated with the particles. Particles were detected in the blood after 5 minutes. The number of particles in the blood peaked at 60 minutes, and then remained constant for a further 2 hours. The smallest particles (20 nm) showed greater uptake than the largest particles investigated (1000 nm). The total maximum uptake seen for the smallest particles was in the order of 3.25% of administered dose. 100 nm particles coated with chitosan showed an increase in both the extent and rate of uptake, with the concentration in the blood peaking at 15 minutes rather than at 60 minutes. It is suggested that transport of the particles across the nasal membrane is due mainly to a transcellular transport mechanisms by the nasal associated lymphoid tissue (NALT), especially the M-cell like cells. However, some paracellular transport cannot totally be ruled out for the smallest particles, especially if coated with chitosan.

Analysis of Variance↗
PubMed1995

The community psychiatric nurse in primary care: an economic analysis.

Community psychiatric nurses (CPNs) in the United Kingdom are increasingly working in primary health care settings with less serious mental health problems. This paper describes an economic evaluation of their work using a randomized controlled trial in which 231 patients were assigned to continuing general practitioner care or one of two conditions of CPN intervention. This is only the third systematic economic analysis of community mental health nursing in the UK and the first carried out by mental health nurses. Various costs to patients, their families and the health care system were determined. Results showed that patients receiving CPN intervention experienced less absence from work and that this resulted in a net benefit. However, the cost per quality adjusted life year for intervening with this group of patients was probably several times more than for intervening with the seriously mentally ill. Therefore, if one considers both the clinical and economic results of the study, taken together with the recent results of the review of mental health nursing, there seems little justification for CPNs continuing to work in this area.

Absenteeism↗
PubMed1994

Community psychiatric nurses in primary health care.

BACKGROUND: Community psychiatric nurses (CPNs) are increasingly working in primary health care with non-psychotic patients. This study was designed to test the efficacy of this work. METHOD: The study was carried out in six health centres in north London with a total of 36 participating general practitioners (GPs) and 11 CPNs. Using a randomised controlled trial, 177 patients were referred by their GP and randomly allocated to continuing GP care, immediate community psychiatric nursing intervention, or placed on a 12-week waiting-list, after which time the patient was offered CPN intervention. A range of measures of symptoms and social function were used, and ratings were carried out at assessment and at 24 weeks. RESULTS: Patients improved on all measures over time (P < 0.001 for all measures). However, there was no difference between the group of patients receiving GP care and patients seen by the CPN. Improvements seemed to be independent of the amount of contact. Drop-out rates from CPN intervention were high (50%). CPN drop-outs were more disabled to start with, but did as well as CPN treatment completers. Patients were more likely to drop out with trained than untrained CPNs. There was no evidence that referral to a CPN saved GP time. CONCLUSIONS: The results add weight to the argument that CPNs should refocus their activity on people with serious mental health problems, and indicate that CPN education should focus on skill acquisition and interventions of proven effectiveness.

Adult↗
PubMed1985

Does marriage influence whether a facially disfigured person is considered physically unattractive?

Many recent studies have supported Dion, Berscheid, and Walster's (1972) viewpoint that "What is beautiful is good." In addition, several studies have found that an individual who is believed to be married to a facially attractive person will be perceived as attractive to other people. Few studies have examined how a disfigured or deformed face is perceived. The present study sought to determine whether perception of facial disfigurement is influenced by marriage to someone who has a normal face. Evidence to support this theory was found.

Association↗
PubMedDate not supplied

Family views of a paediatric outpatient nursing development unit.

This article reports on one aspect of the quinquennial evaluation of a King's Fund accredited nursing development unit (NDU) within a paediatric outpatient department of a large district general hospital during the period 1993-1998. The study draws upon descriptive data obtained through a parental satisfaction survey. Overall the results demonstrate a high degree of satisfaction with the outpatient visit family experience and suggest that the status of NDU has helped the children's outpatient department become more responsive to the needs of families.

Attitude to Health↗
PubMedDate not supplied

Multiprofessional perceptions of a paediatric nursing development unit.

This article describes the final component of the quinquennial evaluation of a King's Fund accredited nursing development unit (NDU) within a paediatric outpatient department of a large district general hospital during the period 1993-1998. The study draws upon descriptive data obtained through a questionnaire distributed to 83 members of staff associated with the outpatient department. Overall, the results demonstrate that NDU status has enabled staff to embrace the change process more readily than might have been possible otherwise. The basic premise that NDUs should promote nursing innovation is explored and critically evaluated.

Attitude of Health Personnel↗
PubMedDate not supplied

Health economics in psychiatric nursing.

The potential benefits to psychiatric nursing of the new science of health economics are explored in this article, which stems from more extensive research carried out by the authors. It is suggested that an analysis of the relationship between costs and clinical outcomes of community psychiatric nursing interventions will enable an objective ratification of the costs and benefits of treatment to emerge. The new discipline must be incorporated into evaluative research processes to allow psychiatric nursing to have an influence over future changes in health care provision.

Community Health Nursing↗
PubMedDate not supplied

Parasuicide.

Explore the source record for details and available documents.

Adolescent↗