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Biomedical subjects

J Brookfield

Publications and source records attributed to J Brookfield.

10 recordsLinked to original sources
PubMed1992

The effect of population subdivision on estimates of the likelihood ratio in criminal cases using single-locus DNA probes.

The interpretation of single-locus DNA profile evidence in criminal cases in normally performed using an assumption of independence of frequencies of alleles at different loci. The critical parameter is the probability of a suspect matching a criminal's DNA profile by change. Many authors have been concerned that the assumption of linkage equilibrium may be inaccurate and that the strength of evidence against suspects may be thereby exaggerated. Some have calculated the maximum size of this effect. What matters, however, is not the upper bound of what the true probability might be, but what the actual probability is in a subdivided population. By calculating this, one can show that the effect of population subdivision on the strength of DNA profile evidence is very minor.

Alleles↗
PubMed1991

Multiple paternity in wild common shrews (Sorex araneus) is confirmed by DNA-fingerprinting.

We have tested for the occurrence of multiple paternity in wild common shrews by karyotypic analysis and DNA-fingerprinting of five wild-caught females and their litters. Karyotypic data suggest that some litters were sired by more than one male, but provide no definitive evidence. By using DNA-fingerprinting, it was possible to establish that two males sired the litter of two females. The present report shows that multiple paternity is not a rare phenomenon in the common shrew and by using DNA-fingerprinting it is possible to assign individual offspring to different male parents even when none of the putative fathers are available for inspection.

Animals↗