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Biomedical subjects

J Brodehl

Publications and source records attributed to J Brodehl.

At least 163 records · Page 9Linked to original sources
PubMed1977

[The changing meaning of the term nephrosis since Noeggerath (author's transl)].

The term nephrosis has changed its meaning considerably since it was coined by Friedrich v. Müller. At the time of Noeggerath, whose 100 anniversary just has passed, nephrosis was defined by morphological terms describing various histological alterations of the renal tubuli which were considered to be degenerative. Today nephrosis is a clinical diagnosis, and usually called nephrotic syndrome. It is characterized by heavy proteinuria and hypoalbuminemia, and can be produced by various etiological causes. In pediatrics the most frequent type is lipoid nephrosis which is characterized by minimal glomerular lesions, negative immunofluorescence and steroid responsiveness. Patients with frequent relapses of lipoid nephrosis are difficult to handle by the physician, therefore the "International Study of Kidney Diseases in Children" and the "Arbeitsgemeinschaft für Pädiatrische Nephrologie" are conducting cooperative therapeutic trials, which results are mentioned briefly.

Child↗
PubMed1975

[Acute renal failure after intracranial injury in three children: analysis of possible causes (author's transl)].

In three children (aged 6-8 years)acute renal failure developed three to five days after head injury. After emergency treatment and measures to prevent cerebral oedema, two of the children were given simultaneously dextran, cefalotin, gentaminic and beta-aescin. The dosage of these drugs was much higher than the usual upper limbs, beta-aescin in doses as high as 10 to 20 fold above recommended maximum. There was no proven connection between the drugs and their dosage and renal failure, because many factors were involved. However, in intensive treatment for children an exact control of drug dosage essential because toxic side effects of different drugs can be potentiated. All three children were haemodialysed, renal function recovered and all were discharged without organic sequelae.

Acute Kidney Injury↗