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Biomedical subjects

J Bret

Publications and source records attributed to J Bret.

At least 19 recordsLinked to original sources
PubMed2006

Clinical and densitometric efficacy of the association of interferon alpha and pamidronate in the treatment of osteoporosis in patients with systemic mastocytosis.

Osteoporosis accompanying severe mastocytosis leads to numerous compressed vertebrae. We treated four patients (mean age 52 years) with severe osteoporosis and mastocytosis proven by bone marrow biopsy (more than 40 mast cells/mm3), according to the following protocol: interferon alpha (IFN) 3 million units (MU) three times a week, reduced to 1.5 MU three times a week in the event of intolerance, and pamidronate (Pam) 90 mg/month in infusion. This treatment was given for 2 years. It was followed by Pam alone at a dose of 90 mg/month. After 3 or 4 years of treatment, no patient presented new vertebral or extravertebral fractures. The mean increase in bone mineral density (BMD) with IFN and Pam was 16.05+/-6.12% at the spine, 5+/-2.24% at the femoral neck, and 4.12+/-3.03% for the whole body; the increase or loss of BMD with Pam alone was +0.2+/-2.13% at the spine, -2.25+/-2.78% at the femoral neck, and -0.1+/-3.35% for the whole body. In one patient, the IFN dose was halved because of a flu-like syndrome, and in another IFN was discontinued at one year for the same reason. The association of IFN and Pam led to a major increase in bone marrow density in osteoporosis with concomitant mastocytosis and this gain was then maintained by monthly infusions of Pam.

Adult↗
PubMed1989

[Clinical aspects and therapy of adult hydrocephalus associated with stenosis of the aqueduct of Sylvius].

The author describes 11 cases of adult hydrocephalus based on stenosis of the aqueduct of Sylvius. She describes clinical manifestations and diagnostic possibilities. CT examination and positive VG are most useful for the diagnosis. Clinical signs of rising intracranial pressure, considerable narrowing of or absence of the filling of the aqueduct and hydrocephalus are in the author's opinion the most important criteria of operation. Recanalization of the aqueduct of Sylvius by a drainage tube according to Bret is the optimal surgical approach.

Adult↗
PubMed1988

[Sophrology].

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Consciousness↗
PubMed1987

Diagnostic-therapeutic ventriculocystostomy.

Simple diagnostic-therapeutic ventriculocystostomy is described. Arachnoid, intracerebral, or intraventricular cysts are permanently connected with the ventricles by a Kifa red catheter with spirally situated holes. The pressure balance and the connection with a physiological space for resorption is maintained in this simple way. Twenty patients have been operated on over a 2-year period with good results.

Arachnoid↗
PubMed1985

Septal aneurysm with associated anomalies.

A 15-year-old boy had a history of a functional systolic murmur with systolic and diastolic murmurs and radiological evidence of left ventricular hypertrophy. The angiocardiogram demonstrated an aneurysm of the membranous septum, bicuspid aortic valve, dilatation of the left subclavian artery and left common carotid artery. Echocardiography showed a holosystolic prolapse of the mitral valve with mitral insufficiency and a bicuspid aortic valve with insignificant incompetence of the aortic valve. Classical TM mode echocardiography did not show an aneurysm of the membranous septum.

Adolescent↗
PubMed1981

Recanalization of Sylvian aqueduct.

Disorders of the free passage of the C.S.F. through the Sylvian aqueduct are among the common causes of intracranial hypertension. After the partial or complete obstruction of the aqueduct, the intracranial hypertension may be produced by three different mechanisms - a) by hypertensive hydrocephalus of the third and lateral ventricles, b) by the combination of hydrocephalus and the space-occupying lesion or c) by the acute obstruction of the aqueduct with acute dilatation of the third and lateral ventricles. The supratentorial hypertension may be, in some cases, transferred to the posterior fossa via the incisura tentorii. For many years, neurosurgeons have been trying to restore the free passage of C.S.F by different surgical techniques which could make possible free outflow of supratentorial hypertension. The number of procedures suggested has proved the importance of the obstruction of the Sylvian aqueduct and difficulties in its treatment (5, 6, 14, 15, 16, 17, 18, 19). Since 1972, the selective ventriculography of the third and fourth ventricles with Conray 60 (1, 2, 3, 4, 7, 8, 9, 10, 11, 12, 13, 20, 21) was performed by the author in 1005 patients and pathological findings were proved in 602. Our of 602 patients with pathological findings, the aqueductal stenosis was proved in 39 and complete obstruction of aqueduct in 168 patients, i.e. in 28 per cent of all pathological findings. The new techniques of interventriculostomy (third to fourth ventricle shunt) using Seldinger's technique is described, presented and documented by x-ray pictures. This technique has been used on 5 patients successfully treated upto now.

Brain Neoplasms↗