[Treatment of dermatomycoses].
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Anti-Infective Agents, Local↗
Biomedical subjects
J Brasch
Publications and source records attributed to J Brasch.
Dominance of memory over naive T cells in contact dermatitis is due to differential tissue immigration.
CD4+ T cells include a naive (CD4-, CD45RO-, CD29-, CD45RA+) as well as a memory subpopulation (CD4+, CD45RO+, CD29+, CD45RA-). These subpopulations represent different stages in T-cell development and function. Recently, it has been shown that inflammatory and neoplastic CD4+ T-cell infiltrates are dominated by the memory subpopulation, whereas both subpopulations are about the same size in the peripheral blood. This was thought to be the result of in situ maturation of naive into memory T cells. We analysed early positive patch-test reactions 1-2 days after antigen challenge and found that most of the CD4+ T cells that had freshly immigrated into the tissue carried the memory phenotype. Their preferential migration may be mediated by at least five adhesion molecules expressed on their cell surface. This observation has important pathogenetic implications, since memory T cells can be rapidly activated by antigens and secrete a wide variety of pro-inflammatory cytokines.
Antigens, CD↗
[Pathogens and pathogenesis of dermatophytoses].
The principles of taxonomic and systematic classification of dermatophytes are described with an emphasis on the relevance of teleomorphic forms. Special attention is given to their relation to dimorphic fungi and the formation of arthroconidia as a parasitic growth form. The main factors contributing to pathogenicity of dermatophytes are explained, including enzymes (especially keratinases), allergens and leukotaxins. Genetic predisposition and the unspecific (serum factors, polymorphoneutrophilic granulocytes) and specific immunological mechanisms of host defence are differentiated and critically evaluated.
Arthrodermataceae↗
Microsporum canis with polymorphous macroconidia.
An atypical strain of Microsporum canis was isolated in our laboratory, which was characterized by a variety of polymorphous macroconidia. These are demonstrated by illustrations. Based on our observation and literature, the relationship between Microsporum canis and Microsporum distortum is discussed. Epidemiologic aspects are mentioned.
Animals↗
Ribosomal RNA gene amplification: a selective advantage in tissue culture.
A CCRF-CEM (human T-cell leukemia) line, initially made resistant to methotrexate by a four-step increase in drug concentration, revealed a large marker of one chromosome #14 in all cells after a 6-month period of culture in the absence of drug. The marker is the result of a triple duplication of both the satellite and stalk. In situ hybridization with 3H-cRNA and NOR banding proved that ribosomal DNA had been amplified and was actively transcribed. Flow cytometric analysis showed a significant increase of RNA versus DNA in G1 cells compared with those of the original drug-resistant parent. The abnormal chromosome appeared after the removal of methotrexate from culture and may be related to the faster doubling time of this line compared with the parent line.
Chromosome Banding↗
[An unusual strain of Trichophyton rubrum from Schleswig-Holstein].
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Bacteriological Techniques↗
[Porokeratosis plantaris, palmaris et disseminata].
A 74-year-old patient has been affected for about 40 years by hardly discomforting keratotic lesions of the trunk and extremities, especially on the palms and soles. Some of his children and grandchildren have shown similar lesions. Histologically the diagnosis of porokeratosis was established by demonstration of a cornoid lamella. Clinically it appeared to be the rare form of porokeratosis plantaris, palmaris et disseminata, in which mainly the palms and soles are affected by hyperkeratotic papules, but nearly the whole body may be involved. It is discussed how this genodermatosis can be differentiated from other forms of porokeratosis. The family tree of our patient is compatible with autosomal dominant inheritance.
Aged↗
Large retroperitoneal cysts in children and adolescents.
Retroperitoneal cysts may be divided into those of urogenital origin: pronephric, mesonephric, metanephric and müllerian; mesocolic; teratoma; lymphatic; parasitic, and traumatic blood cysts. Müllerian cysts are thought to originate from the specialized mesothelial cells of the genital ridge and present as fimbrial cysts or broad ligament wolffian cysts. Symptoms may be absent, or the result of pressure or displacement of an organ. Diagnosis is made by x-ray studies, sonographic evaluation and, frequently, at operation. We report a case of a 14-pound cyst arising from the right broad ligament and partially obstructing the right ureter that was removed surgically.
Adolescent↗
Revascularization after 3 hours of coronary arterial occlusion: effects on regional cardiac metabolic function and infarct size.
Two experimental series of closed chest dogs were compared: Group A (five dogs with 7 days of continuous occlusion of the proximal left anterior descending coronary artery); and Group B (six dogs with 7 days of reperfusion after 3 hours of acute occlusion of the same artery). Hemodynamic measurements, ventricular wall motion, coronary sinus blood flow and regional metabolism in both coronary occluded and nonoccluded segments of the left ventricle were measured sequentially. The infarct size was characterized by detailed histopathologic analysis. In the control dogs (Group A), mechanical and metabolic function remained severely depressed after 7 days of occlusion, and mean infarct size was 31.6 percent. In Group B, significant mechanical and metabolic dysfunction developed during 3 hours of occlusion and did not improve during the 1st hour of reperfusion. However, after 7 days of reperfusion, function returned to near preocclusion level. Mean infarct size was 14.2 percent, but in two of the six dogs infarct size was 43 percent and 23 percent, respectively. The study confirmed the unstable character of the early phase of reperfusion, attributed to cell swelling, edema and hemorrhages that resulted in inadequate coronary reflow, arrhythmias and functional derangements. Prolonged reperfusion for 7 days reduced mean infarct size and improved cardiac function.
Animals↗
Consequences of coronary arterial occlusion on remote myocardium: effects of occlusion and reperfusion.
Focal necrosis (microinfarcts) and regional lactate derangements were observed in closed chest dogs in the nonoccluded (remote) posterior segments of the left and right ventricles after acute occlusion of the proximal left anterior descending coronary artery. Focal infarcts in the remote areas were observed in five of the six dogs with 7 days of occlusion of the left anterior descending artery and in six of seven dogs with 7 days of reperfusion after 3 hours of occlusion. There was a good correlation between the finding of microinfarcts and myocardial lactate derangements in the corresponding remote myocardium. No significant lactate derangements or microinfarcts were found in sham experiments. These findings suggest that ischemia of the remote myocardium frequently accompanies an acute coronary occlusion and may result in irreversible focal lesions.
Animals↗
[Endogenous methemoglobinemia caused by polyresistant E. coli].
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Aged↗
A simple method for the autoradiography of soluble isotopes. Autoradiography of soluble materials.
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Autoradiography↗
H 3-thymidine distribution in the chromosomes of mammalian bone marrow cells after administration of various radioprotectors.
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Animals↗
The action of a radioprotector (AET) on the distribution of H-3-thymidine in bone marrow chromosomes of the rat. AET-action on the uptake of labelled thymidine by chromosomes.
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Animals↗