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Biomedical subjects

J Boyle

Publications and source records attributed to J Boyle.

At least 91 records · Page 5Linked to original sources
PubMed1986

A microcomputer program of pulmonary and tissue gas exchange.

A microcomputer program written in BASIC for the IBM-PC and compatibles has been developed to analyze the effects of many parameters on the gas exchange and transport phenomena in the lungs and the tissues. The program is designed for use by medical students and residents concerned with gas exchange (anesthesiology, pulmonary diseases, critical care, etc.) to study the steady state effects on blood and tissue oxygen and carbon dioxide levels. The present program consists of two main subroutines: Pulmonary Gas Exchange and Tissue Gas Exchange. Steady state gas exchange at the lungs can be studied using either a three-compartment model or V/Q relationships. The V/Q subroutine uses single or multiple populations of V/Q distributions to determine gas exchange using a log-normal distribution of V/Q ratios. Other variables can be adjusted which determine the arterial and mixed-venous blood gases. These values are then fed into the second part of the program to analyze factors which determine tissue O2 tension. The Tissue Oxygen Tension subroutine is also subdivided into a modified Krogh-Erlang model, which provides a three-dimensional plot of theoretical capillary and tissue O2 tensions, and a Piiper model which includes the effect of diffusion shunt on O2 tensions and treats the tissue as a well-stirred compartment. Minimal and maximal tissue O2 tensions are calculated using the Piiper model since the intercapillary distance is allowed to vary depending on the O2 delivery by diffusion. Estimates of blood and tissue O2 tensions, diffusion/perfusion coefficients, amount of O2 delivered and the size of the active capillary bed are summarized in a table.

Computers↗
PubMed1986

Hydroquinone concentrations in skin lightening creams.

Forty-one over-the-counter skin lightening creams were analysed for hydroquinone content, and the accuracy of tables of contents supplied with these products was assessed. Eight of the 41 were found to contain more than 2% hydroquinone, the maximum concentration permitted by the U.K. Cosmetic Products Regulations. Eighteen of these preparations failed to comply with labelling requirements. A list is given of those products containing less than 2% hydroquinone which are adequately labelled.

Consumer Product Safety↗
PubMed1985

Knee rehabilitation following arthroscopic meniscectomy.

Guidelines for knee rehabilitation after conventional open meniscectomy are generally well known. Less agreement exists on rehabilitation following arthroscopic meniscectomy. The program is sometimes arbitrary. Rehabilitation should follow a logical progression regardless of the type of surgery performed. Rehabilitation following knee surgery can be divided into four phases: immediate post-operative period, early healing phase, late healing phase, and conditioning for return to preinjury activity. Following arthroscopic surgery, the overall recovery time can be significantly shortened compared to conventional arthrotomy, primarily by decreasing the length of the early postoperative phases. A smaller incision causes less soft-tissue injury to skin, capsule, synovium, and other periarticular structures, resulting in less quadriceps inhibition and a more rapid recovery. The rate of tissue healing is not altered, however, and the knee must still heal completely before the patient can return to a full functional level. Not all patients are rehabilitated uniformly, and a great deal of variability exists following arthroscopic surgery. Factors that affect the speed of rehabilitation and return to normal function are the extent of meniscectomy performed, the coexistence of additional intra- or extra-articular pathology, and individual patient differences. Therefore, an arbitrary time frame for rehabilitation following arthroscopic meniscectomy is not recommended. Rather, each patient should progress from one stage of rehabilitation to the next, based on objective knee findings.

Arthroscopy↗