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Biomedical subjects

J Bovet

Publications and source records attributed to J Bovet.

32 records · Page 2Linked to original sources
PubMed1984

[1st juvenile case of complex neurolipidosis and neuroaxonal dystrophy involving the central nervous system].

What is apparently the first reported case of neuroaxonal dystrophy associated with juvenile neurolipidosis is described. Details of the clinical evolution and the macroscopic, microscopic, histochemical and ultrastructural anatomo-pathology are given. The topographical distributions are given of the two characteristic lesions: swelling of neuronal cell bodies and swelling of axons. Biochemical and histochemical analyses were made but since the specimen had been preserved in acetone it was not possible to identify which lipids were present in excess. The case is compared to 5 somewhat similar cases in the literature.

Adolescent↗
PubMed1984

Bromazepam ('Lexotanil') compared with placebo: a double-blind, crossover study.

A double-blind, crossover study was carried out in 126 out-patients, most of them neurotics, to compare the efficacy and tolerance of bromazepam and placebo. Patients received either 6 mg bromazepam or placebo daily for 3 weeks and were then crossed over to the alternative treatment for a further 3 weeks. Treatment sequence was randomized. Clinical ratings of the severity of individual symptoms and the Hamilton Anxiety Rating Scale were used to measure response to treatment at the end of each period. During the first period, both bromazepam and placebo produced improvement and there was no statistically significant difference between the two groups. During the second period after crossover, however, significantly better results were achieved in patients on bromazepam than those on placebo. The incidence of side-effects, mainly drowsiness, was similar with bromazepam and placebo.

Adolescent↗
PubMed1980

Evaluation of psychotherapies and Osgood's Semantic Differential. A tentative approach.

Setting up a semantic differential according to Osgood for evaluating analytical psychotherapies: a selection of scales and inducive words plus a factor analysis based on answers obtained from two test groups--the one composed of ambulatory psychiatric patients, the other composed of normal individuals. Preliminary validity tests of the results for applicability in clinical situations: examples of individual semantic configurations reflecting in a plausible manner certain clinical characteristics; comparison of the configurations of a group of neurotics with those of a group of schizophrenics; example of the evolution of one configuration during the period of psychoanalytical treatment. These first tests led us to believe that the semantic differential could contribute effectively to the evaluation of psychotherapies.

Humans↗
PubMed1979

[The future of suicidal patients admitted to a general hospital. Comparative study of 2 methods of prevention recurrence and of suicides].

This is a comparative study of two groups of suicide attempters admitted in a general hospital, who were treated in different ways. The 143 attempters of the "systematically treated group (STG)" were proposed the classical therapeutic measures (supportive psychotherapy, psychiatric hospitalization, crisis interventions within couples or families, mixed interventions with the above treatments, psychoanalytically oriented psychotherapy, etc.), plus ambulatory controls (a few days after discharge from the general hospital, after one month, three months, six months, a year, and two years). The 145 attempters of the "reference group (RG)" were proposed the classical measures only. All the attempters of both groups had a follow-up after two years. The results suggest the controls to be probably responsible for the difference of relapses and committed suicides between the two groups. More indirectly, this study facilitated a further analysis of the relational problems between suicide attempters and staff, and among staff members themselves. The consequences were a modification of some attitudes of the staff toward the attempters and their significant others, and a new collaboration for an interdisciplinary clinical research.

Adolescent↗
PubMedDate not supplied

[Diffusion of O2 in the normal and the ischemic retina of miniature pigs].

Transretinal PO2 profiles were recorded during normoxia and hyperoxia in normal and ischemic retinal territories in anesthetized miniature pigs using double barrelled recess type microelectrodes. In normoxia and hyperoxia the PO2 in the normal territory decreased from the inner retina and the choroid towards the mid-retina, indicating that the choroid cannot supply O2 to the whole normal retina. Preretinal and transretinal PO2 measurements in ischemic territories following a laser occlusion of a retinal branch vein demonstrated that in normoxia the direction of PO2 gradients prevents O2 diffusing from the choroid to reach the inner retina. This explains why the ischemic territories are hypoxic. In the contrary, during hyperoxia the intraretinal PO2 gradient indicates an O2 flux from the choroid to the inner retina resulting to marked preretinal PO2 increase at the affected territories. We proposed the hypothesis that in the ischemic retinas the hyperoxia does not induce a rise of the O2 consumption of the outer retina. Hence hyperoxia could be a useful tool to restore the oxygenation of the inner hypoxic retinal layers.

Animals↗
PubMedDate not supplied

[Subjective perception of the effect of neuroleptics by outpatient schizophrenic patients: a cross-sectional study].

UNLABELLED: Subjective response to neuroleptics is essential to long term observance of treatment and quality of life of patients. Numerous factors (pharmacological, relational and psychopathological) are responsible of this subjective response. Objectives of this study are: (a) to examine psychometric features of the french version of the Drug Attitude Inventory (DAI-30) [13] and (b) to explore pharmacological, relational and psychopathological factors related to this subjective response. SUBJECTS AND METHODS: 78 subjects were rated (self rated response rate 61% (n = 48)) for (a) subjective response to neuroleptics, (b) compliance, (c) therapeutic alliance, (d) symptoms (e) severity of disorder. RESULTS: Factor analysis yielded 2 main clinically relevant factors, similar to the original version: (I) global subjective response and (II) specific subjective response. Internal consistency is high. Correspondance analysis showed two important dimensions in the treatment of schizophrenic patients: (I) Recovery--aggravation, (II) Therapeutic ambition--positive or negative symptoms. CONCLUSION: French version of DAI-30 seems to have a similar structure and psychometric features as the original version. It shows concordance with the degree of compliance. Pharmacological factors are not the only factors implicated in subjective response, but are still to be identified. Limitations of our study are: (a) nonhomogenous indication for treatment, (b) small rate and degree of non compliance in our sample. Relationships between therapeutic ambition, type of symptoms and treatment outcome should be further studied.

Adult↗