Effective prevention of preterm birth: the French experience measured at Haguenau.
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Biomedical subjects
Publications and source records attributed to J Bouyer.
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Between 1971 and 1985, at the Haguenau Maternity Hospital, a 20% decrease was observed in the rate of small-for-gestational-age infants (birthweight less than 10th centile using figures from all the study births) among 20,101 births between 28 and 42 weeks. This decrease could not be explained by simultaneous changes in socio-demographic and anthropometric characteristics of the pregnant women, nor a recruitment bias. The earliness of prenatal care at the Maternity Hospital may have played a role in the downward trend. Further research is needed to confirm the influence of prenatal care on the rate of small-for-gestational-age babies.
A preterm birth prevention program was instituted in France in the early 1970s. Its effectiveness has been assessed through a perinatal study in Haguenau. A relationship between prenatal care improvement and preterm birth rate decrease was noted, but a causal interpretation cannot be derived from such an observational study. However, some arguments do support this interpretation: no satisfactory alternative explanation (such as biases in pregnancy duration measurement, change in the composition of the population of pregnant women, or secular trend), a plausible causal pattern, and a dose-response relationship between prenatal care and preterm birth rate. The Haguenau study results can be applied to other French regions, but extrapolation to other countries would depend on their social, medical and cultural contexts.
A major modification in French national perinatal policy was proposed in 1970. Its primary aim was to reduce preterm births, and a specific program has been progressively applied to all pregnant women in France since 1971. Because the policy was introduced at a national level, it was possible to use a district hospital in Haguenau (northeastern France) as an observation site for measuring the effects of the change. A longitudinal study was begun in 1971 and continued for 12 years, during which time a total of 16,004 singleton pregnancies were followed. This article focuses on acceptance by the pregnant women in Haguenau in response to the new prenatal care proposals. A major reduction in preterm births is demonstrated, and the relationship between acceptance and observed changes in preterm birth is discussed. Certain time-related patterns were observed: it took time for the policy modification to be measurable; while the outcomes showed general improvement, results were closely related to the patient's social status; there were significant time-lag differences between social class groups with regard to acceptance of specific interventions.
Analysis of 8972 pregnancies and 5089 interpregnancy intervals, computer-registered over 12 years at the Haguenau Hospital Maternity Department, showed that the length of interpregnancy interval may be considered as a risk factor in spontaneous abortion; this was still true after other important known risk factors, i.e. maternal age, parity, previous spontaneous abortion and contraceptive practice, had been taken into account. However, separate analysis of pregnancies according to whether they occur more or less than 1 year after contraception (if used) had been stopped showed that the relationship between a long interval and spontaneous abortion was only significant for subfertile women who took longer than 1 year to conceive. This supports the hypothesis that the same mechanism is involved in the aetiologies of spontaneous abortion and of difficulty in conceiving.
A group of 8303 women was studied to determine the timing of cervical ripening. It was confirmed that these signs of cervical change can be observed several weeks before preterm births. The precocious signs of external ripening can be recognized during a vaginal examination and may be useful in predicting preterm labor.
A prospective study was conducted on 7937 pregnancies, 4430 of which had prenatal visits before 37 weeks of gestation. Induced preterm deliveries were excluded (N = 40). Then the data was incorporated from the visits (cervix status, uterine contractions) as well as some common indicators of risk for preterm birth (mother's age, social status, obstetric antecedents, bleeding) into a predictive scoring system for spontaneous preterm labor. Different scores were computed according to both parity and to the timing during pregnancy when the signs were observed. It was found that approximatively 25% of the total preterm births were connected with the presence of at least one of three maturation signs of the uterine cervix (dilation of the internal os to 1 cm, cervical length less than 1 cm, and presence of painful uterine contractions).
A reduction in preterm births has been observed in Haguenau (Eastern France) during a 12-year intervention study with a program for prevention of preterm deliveries. The Perinatal Study of Haguenau was an observation tool used in a stable population, and it allowed measurement of the way women have progressively responded to the new proposals in prenatal care. It also allowed measurement of the results of the interventions: low birth weight (less than 2,500 g) and preterm birth rates (less than 37 weeks of gestation) among single live births. The total duration of the study was divided into three periods of four years (1971 through 1974, 1975 through 1978, and 1979 through 1982), for which the numbers of single live births are 5,763, 4,957, and 5,919, respectively. For the same periods, the low-birth-weight rates, 4.6%, 4.0%, and 3.8%, respectively, showed a significant decrease (P less than .001). Following a similar pattern, the rates of preterm birth were 5.4%, 4.1%, and 3.7% (a significant reduction with P less than .001). These improvements in pregnancy outcome do not disappear after standardization of mother's age, high blood pressure, or social class distribution. These findings, which concur with the results of others, enhance the hypothesis of a direct relationship between a prevention program and a reduction in preterm birth rates.
All children born between 1971 and 1974 at the Haguenau maternity center (Lower-Rhine department, N.E. France) and attending school in Haguenau were examined by school doctors. The paper shows that there were differences in development of the 3 groups studied: 54 children born before term, 62 born small-for-dates and 1,188 controls. The rapid growth rate observed in the preterm children enabled them to catch up with the controls in physical growth criteria, in contrast to those in the small-for-dates group. Overall, those in the preterm group seemed to enjoy better health than those in the small-for-dates group, but their adaptation to school life was poorer.
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A reduction in preterm births has been observed in Haguenau, eastern France, during a 12-year intervention study on prevention of preterm deliveries. Between 1971 and 1982 there was also an increase in the proportion of women who attended the prenatal clinic in the first trimester, and an increase in the mean number of visits in the first 6 months of pregnancy. These changes were observed in women of all educational levels. This investigation illustrates the use of time-trend studies in the field of health technology assessment.
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