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Biomedical subjects

J Bond

Publications and source records attributed to J Bond.

At least 127 records · Page 7Linked to original sources
PubMed1982

Effects of feeding level on growth, composition of gain, carcass quality and mature body size in steers at ages up to six years.

Tissue gain and efficiency and carcass characteristics of seventy-eight Angus steers were compared on three feed intake regimens and serially slaughtered at 6 months to 6 years. The regimens were: (A) continuous ad ad libitum feeding, (B) restricted to gain about 0.45 kg daily and (C) restricted as in B until 6 months before slaughter then fed ad libitum. Steers, regardless of feeding regimen, made their greatest gains up to 12 months of age and became less efficient after that time. Steers fed ad libitum had the highest percentage of fat but the lowest percentage of lean and bone when compared with steers fed for restricted gain. Carcasses of the steers fed ad libitum contained more lean and fat at each slaughter age. Average daily gain, feed efficiency and percentage of lean and bone decreased with age; and feed intake, slaughter grade, dressing percent, taste panel desirability and percent of fat tended to increase with age. All steers reached their maximum growth in height at withers, depth of chest and length of body at about 3 years. Steers that were restricted up to 6 months before slaughter showed compensatory growth during their ad libitum feeding period and during the first 12 months of the study; protein and fat were produced most efficiently by this growth. It would appear that it is possible to modify fat deposition by changing feed intake level.

Adipose Tissue↗
PubMed1981

In vitro effect of some mutagens/carcinogens on cultured fish cells.

Fibroblast cells derived from juvenile bluegill sunfish were tested for their response the effects of known mutagens/carcinogens. The cells grew well and cloned in Eagle's minimal essential medium which contained fetal bovine serum. Growth rate was temperature dependent and increased steadily as temperature was raised from 15 to 33 degrees C. Direct mutagens and promutagens were toxic to the cells, and fluorescence spectroscopy revealed the capability of metabolizing at least one promutagen, benzo(a)pyrene, to water-soluble intermediates. Ouabain resistant mutants were produced by exposing the cells to N-methyl-N-nitro-nitrosoguanidine (MNNG) or to benzo(a)pyrene (B(a)P). The mutant clones were resistant to 100-fold increases in concentration of the selective agent ouabain, over that which was lethal to wild type cells. Spontaneous mutation frequency to ouabain in mass cultures averaged 1.2 X 10(-6) for all experiments. A fluctuation test confirmed an expected random occurrence of spontaneous mutations. Visible crystals formed within the cells when high concentrations of B(a)P (greater than 5 micrograms/ml were added to the tissue culture medium. Crystal formation resulted in no apparent cell damage but did reduce the growth rate of the cultures. The crystals were rhombic, resembling those described for pure native B(a)P, and gradually disappeared when the cells were exposed to mutagen-free medium which contained serum.

Animals↗
PubMed1980

Observations on the muscle abnormality of the human sigmoid colon in diverticular disease.

1 Pharmacological experiments were performed on circular and longitudinal muscle strips of sigmoid colon from diverticular disease specimens, and their responses compared with those of similar muscle strips from sigmoid colon resected from carcinoma (control). 2 The longitudinal muscle strips from diverticular disease specimens were significantly less responsive to acetylcholine, histamine or noradrenaline than control longitudinal muscle strips. 3 The responses of the diverticular circular muscle strips showed a small decrease to acetylcholine, a small increase to noradrenaline and no change to histamine when compared to control strips.

Acetylcholine↗
PubMed1980

The reliability of a Survey Psychiatric Assessment Schedule for the elderly.

The Survey Psychiatric Assessment Schedule (SPAS) was used in a survey of elderly people living at home and in institutions to examine its reliability in determining mental state. A psychiatrist assessed the same subjects using the Geriatric Mental State Schedule (GMSS) and classified psychiatric disorder into three broad groups: organic disorders, schizophrenia and paranoid disorders, and affective disorders and psychoneuroses. The agreement between the psychiatrist's classification of mental state and the classification derived from SPAS was found to be satisfactory for organic disorders and less satisfactory for functional disorders. The limitations of this method of identifying psychiatric illness are examined.

Aged↗
PubMed1978

Cimetidine and gastric blood flow.

The influence of cimetidine on blood flow to the gastric corpus and antrum of the dog was studied using the double isotope microsphere distribution technique. This H2 receptor antagonist caused no changes in blood flow to any portion of the stomach nor did it alter systemic circulatory parameters. The therapeutic effects of cimetidine in diffuse gastric mucosal bleeding depend on some factor other than microcirculatory changes.

Animals↗
PubMed1977

Chronic synovitis with early cartilage destruction in sickle cell disease.

Two patients with sickle cell disease presented with joint pain and early x-ray evidence of articular cartilage loss. Both later developed increasingly destructive arthritis with chronic synovitis identified in synovial biopsies. One patient developed demonstrable aseptic necrosis. Destructive arthropathy is much less common than the frequent transient effusions in sickle cell disease.

Adult↗
PubMed1975

Effects of organic phosphate systemic insecticides on bovine embryonic survival and development.

Experiments were conducted to determine effects of 2 organic phosphate systemic insecticides on embryonic survival and possible teratogenesis in cattle. A total of 726 heifers at 3 locations were treated with either crufomate (4-tert-butyl-2-chlorophenyl methyl methylphos-phoramidate) or coumaphos (O,O-diethyl O-(3-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl) phosphorothioate). The compounds were administered to pregnant bovine females at various stages of gestation by pouring along the dorsal midline. None of the treatments, including those at recommended one-time doses, one-time doses at double or triple the recommended dose levels, or doses at recommended one-time dose levels repeated each day for 10 days, gave evidence of increasing embryonic death rates or of teratogenic effects. In one experiment, the crufomate compound had apparent erratic effects on serum ace5ylcholinesterase activities, but no effects on electrocardiographic patterns, heart rate, or respiration rate. Rectal palpation for pregnancy determination during the 35- to 44-day stages of pregnancy is discussed as a possible, but unsubstantiated, cause of congenital malformation of the caudal portion of the intestinal tract in 1 calf born during these studies and in other calves previously observed.

Abnormalities, Drug-Induced↗