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Biomedical subjects

J Bohl

Publications and source records attributed to J Bohl.

At least 91 records · Page 5Linked to original sources
PubMed1987

The nature of host tissue destruction in tumor invasion. An experimental investigation on carcinoma and sarcoma xenotransplants.

The nature of host tissue destruction in tumor invasion was investigated in experimentally induced carcinomas and sarcomas, xenografted into skeletal muscle. By means of light and electron microscopy it was shown that in both carcinomas and sarcomas the confrontation of host tissue with the invading tumor cells does not result in immediate destruction of host tissue but in a transitory state of coexistence which gradually proceeds to progressive host tissue atrophy. This process of progressive atrophy, which finally results in the total disappearance of the invaded host tissue, is considered to be caused mainly by the increasing pressure and competitive withdrawal of oxygen and nutrients by the invading and proliferating tumor cells. Morphological changes suggesting an active enzymatic breakdown of host tissue cells by tumor cells were not observed during any stage of tumor invasion.

Adenocarcinoma↗
PubMed1987

[MR tomography of benign brain tumors].

69 Patients with benign brain tumours were examined via MRI (30 meningiomas, 17 pituitary adenomas, 14 acoustic neuromas, and 8 craniopharyngiomas). Typical morphological characteristics and values of the MR tissue parameters (T1, T2, Rho) are presented. The combined analysis of tissue parameters and morphological details allows a satisfying differentiation between different pathohistological entities. Tumour capsule and displacement of neighbouring structures without signs of infiltrating growth are typical criteria of benign neoplasms.

Adenoma, Chromophobe↗
PubMed1987

Acute trimethyltin limbic-cerebellar syndrome.

An acute limbic-cerebellar syndrome was seen in six industrial workers who inhaled trimethyltin (TMT). Clinical features included hearing loss, disorientation, confabulation, amnesia, aggressiveness, hyperphagia, disturbed sexual behavior, complex partial and tonic-clonic seizures, nystagmus, ataxia, and mild sensory neuropathy. Severity paralleled maximal urinary organotin levels. One patient died and two remained seriously disabled.

Acute Disease↗
PubMed1987

[MR tomography in glioblastomas and cerebral metastases].

36 Patients with glioblastomas (17 cases) and cerebral metastases (19 cases) were investigated by MRI. The typical signal behavior at different acquisition parameters (T1-, T1/T2-, Rho- and Rho/T2-weighted) was analysed using an interlaced triple sequence. In most cases the NMR-tissue parameter T1, T2 and proton-density (Rho) were determined to evaluate the potentials for tissue characterisation. The results of unenhanced vs. enhanced scans (MRI plus Gd-DTPA, CT) were analysed.

Brain↗
PubMed1986

Esophageal motor function in patients with muscular dystrophy.

In a study designed to evaluate esophageal motor function in muscular dystrophy we examined 13 patients with myotonic dystrophy, 14 patients with "nonmyotonic" muscular dystrophy, and 8 healthy control subjects by manometric and radionuclide transit studies. Patients with myotonic dystrophy exhibited a marked weakness of esophageal contractions and upper esophageal sphincter pressure. Coordination of sphincter relaxation and peristaltic sequences remained unaltered. These changes led to delayed esophageal emptying in all patients with myotonic dystrophy. Although esophageal function was also impaired in the distal esophagus, on histologic studies, morphologic alterations were confined to esophageal striated muscle in a single patient with myotonic dystrophy. In contrast to the marked dysfunction of esophageal motility in patients with myotonia, no such alterations were observed in the "nonmyotonic" form of muscular dystrophy.

Adult↗
PubMed1985

Rare association of herpes simplex virus IgM-specific antibodies and Guillain-Barré syndrome successfully treated with plasma exchange and immunosuppression.

Herpes simplex virus (HSV) has been associated with various neurological disorders. In contrast, HSV infection is very rarely found in acute polyneuroradiculitis. In this report, a patient is described with a severe course of Guillain-Barr¿ syndrome (GBS). HSV IgM-specific antibodies and a rise of complement-fixation antibodies were detected. During the acute phase of neurologic syndrome, a nerve biopsy showed myelin damage and IgM deposits on the inner layer of the perineurium. Plasma exchange, in combination with immunosuppression, was successfully applied as a treatment in the relapsing course of GBS. Finally, after recovery, HSV-specific IgM antibodies disappeared.

Aged↗
PubMed1985

[Median nerve--compression syndrome caused by atypical palm muscle].

A compression syndrome of the median nerve was caused by an atypical M. flexor digiti indicis in the palmar area and carpal tunnel. Apart from its anomalous anatomy, this muscle showed an abnormal histological structure. A persistent median artery was also seen in the carpal canal.

Adolescent↗
PubMed1984

Reno-cerebral oxalosis induced by xylitol.

A 20-year-old man suffering from Crohn's disease developed coma and generalized seizures following ileocecal resection. During postoperative parenteral feeding he received xylitol in an unusually high concentration. CT examinations a few days before death showed intense hypodensity and swelling of brainstem and basal ganglia and increasing triventricular dilatation. Autopsy revealed, mainly in the brainstem and cerebellum, a destruction of intracerebral, intracerebellar and leptomeningeal vessel walls by birefringent crystals (probably calcium oxalate), an early inflammatory reaction and severe brain edema with final tonsillar herniation. The same crystalloid deposits were found in the kidneys.

Adult↗
PubMed1984

Transrenal ureteral occlusion using a detachable balloon.

Percutaneous transrenal ureteral occlusion using a detachable balloon filled with silicone was performed in 20 patients. The main indications were palliation of large urinary fistulas and as a treatment of last resort for severe dysuria in patients with advanced pelvic malignancies. In 6 patients the contralateral kidney was rendered nonfunctional to obviate the need for bilateral nephrostomy. Due to frequent obstruction of the tube, ureteral blockage in 3 became insufficient. Two dislocated balloons were extracted percutaneously and replaced. In order to achieve effective interruption of urinary flow down the ureter, well-functioning external nephrostomy drainage is necessary.

Adult↗
PubMed1983

Hypokalemic rhabdomyolysis associated with Bartter's syndrome.

Severe potassium deficiency is an uncommon cause of rhabdomyolysis. We recently treated a 45-year-old patient with myalgia, serious generalized weakness, increased serum creatine kinase and myoglobin level as well as excessive hypokalemia. Histological examination of deltoid muscle biopsy showed rhabdomyolysis. After complete recovery of muscle damage by potassium substitution Bartter's syndrome proved to be the cause of initial and persistent hypokalemia.

Bartter Syndrome↗
PubMed1983

Lung metastasis of a meningioma.

UNLABELLED: Case report of a 35-year-old male patient. 1976: operation for a falx-meningioma. 1981: meningioma recurrence and further intracranial meningiomas. HISTOLOGY: 1976 and 1981 endotheliomatous meningioma: no signs of malignancy. Prior to the 2nd operation in 1981 a lung tumor was diagnosed for the first time. HISTOLOGY of the lung tumor: endotheliomatous meningioma, same histology as in cerebral meningiomas.

Adult↗
PubMed1983

Senile amyloidosis: principles of localization in a heterogeneous form of amyloidosis.

In order to identify amyloid deposits in patients over 60 years of age (so-called senile amyloid), the following five tissues were investigated under the light and electron microscope: 1. pituitary gland, 2. pancreatic islets of Langerhans, 3. heart, 4. aorta, and 5. brain. In all an increasing incidence of amyloid deposits was found with increasing age, and in the brain a significant quantitative increase in amyloid deposits with increasing age was observed. Despite the biochemical heterogeneity of amyloid found in old age, all the deposits seen in tissues examined were morphologically similar. Typical amyloid fibrils were always found (diameter 60-100 A), and these were invariably deposited extracellularly and primarily on basement membranes. The amyloid-binding basement membranes were in most cases those of myocytic, but were also those of endothelial or epithelial cells. The almost invariable involvement of blood vessels, indicates the importance of these structures in the genesis of the various forms of senile amyloid.

Age Factors↗
PubMed1982

[Imaging adrenergic tumours with 131J-meta-benzylguanidine].

Pheochromocytoma scanning using 131J-meta-benzylguanidine was done in one patient with metastasizing paraganglioma, one patient with multiple endocrine neoplasia type IIb. No activity of tumour tissue could be demonstrated in the patient with metastasizing paraganglioma, whereas the pheochromocytoma could be clearly defined in the patient with multiple endocrine neoplasia type IIa. The female with multiple endocrine neoplasia type IIb showed a suspect space-occupying lesion of the left adrenal using computed tomography. Pheochromocytoma could be excluded by 131J-benzylguanidine scanning, selective estimation of catecholamines in adrenal venous blood as well as the glucagon stimulation and clonidine suppression.

Adrenal Gland Neoplasms↗
PubMed1982

[Massive retroperitoneal haemorrhage in the Bourneville-Pringle syndrome (author's transl)].

Case-report of a 54 year-old patient who was admitted with the clinical picture of an acute abdomen on the basis of intraabdominal haemorrhage. X-ray investigation discounted the diagnosis of ruptured aortic aneurysm, the CAT scan showed a suspected acute haemorrhagic necrotising pancreatitis. At laparotomy, a fatty, bleeding kidney tumour was found growing into the retroperitoneal tissue. The histological frozen-section showed a leimyo liposarcoma of the kidney. Bourneville-Pringle's disease was only afterwards known to be the basic illness of the patient, as was verified at postmortem examination. From the knowledge of these new facts, both the CAT-scan and the intra-operative and histological findings could be correctly interpreted.

Acute Disease↗
PubMed1981

CT studies of brain abscesses in cats.

Cerebral abscesses were produced in 56 cats by introducing staphylococcus aureus into the white matter of one cerebral hemisphere, using a stereotaxic apparatus. The cats were treated with antibiotics and/or steroids. The size and density of the inflammatory process and the abscess ring were measured on postcontrast CT scans. Differences were found depending on the stage of the abscess, but the deviation of values were too great for determining the age of the abscess from one measurement, to be able to apply proper treatment. The size and density of the abscesses were the same on CT whether the animals were treated or not. This was contrary to the clinical picture, the measurements of edema, and the histopathological studies.

Animals↗
PubMed1981

Central nervous system involvement in Whipple's disease.

A case of Whipple's disease is presented manifesting itself predominantly with neurological and mental symptoms but without gastrointestinal complaints. Although the first cranial CT in the fourth year of the disease was normal, the second, 1.5 years later, revealed intensive hypodensity of the white matter and cortical enhancement. CT findings are compared with autopsy results and a review of the pertinent literature is given.

Adult↗