Search PubMed⌕ Search

Biomedical subjects

J Bodalski

Publications and source records attributed to J Bodalski.

At least 37 records · Page 2Linked to original sources
PubMed1998

[Cytoprotective effect of amifostine in children during induction therapy according to BFM-83: report on cases].

Amifostine is the agent of proved cytoprotective activity against alkylating drugs and rubidomycine. Its protective effect against other cytotoxic drugs is doubtful. BFM-83 induction therapy for ANLL (ARA-C + RUB + VP-16) which is applied to children with acute non-lymphoblastic leukemia (ANLL) commonly contributes to severe adverse reactions. We administered amifostine to three children: 2 boys with ANLL (7 and 11 yrs) and 1 girl with MDS (3 yrs) during etoposide and rubidomycine induction therapy in order to decrease chemotherapy-related adverse reactions. Doses of amifostine were 740 mg/m2, 910 mg/m2 and 910 mg/m2 respectively. Efficacy of the therapy was evaluated on the base of blast decline in the bone marrow, efficacy of the cytoprotection by myelo and nephrotoxicity symptoms analysis. Chemotherapy-related adverse effects in the children protected by amifostine were less severe and observed by the shorter periods as compared with the historical control group of 20 patients treated according to BFM-83 without cytoprotection. These cases show the potential beneficial effect of amifostine during BFM-83 induction therapy for ANLL. The further randomised clinical study of the proposed cytoprotection should be performed to establish its value.

Amifostine↗
PubMed1998

[The use of hematopoietic growth factors G-CSF/GM-CSF in the treatment of neutropenia in children with acute lymphoblastic leukemia and non-Hodgkin's lymphomas].

Maximal intensification of antineoplastic therapy is currently a predominant trend in the treatment regimens for acute leukemias and lymphomas. However, by such approach myelosuppression and counteracting its sequelae become paramount problems. Hematopoietic growth factors G-CSF/GM-CSF play a great role in this aspect of the therapy. Effects of 35 courses of G-CSF/GM-CSF were evaluated in 19 children with ALL and NHL and compared with 21 episodes of neutropenia in 15 historical controls. In the treatment group time of neutropenia was approx. 3 times shorter as compared with a control group. Fever accompanying neutropenia occurred less frequently and lasted shorter in the treatment group. Also, symptoms of infection subsided faster. Subjective life quality was better in children receiving growth factors.

Adolescent↗
PubMed1998

[Central venous lines in children with cancers].

Authors analyzed clinical aspects of central venous lines in children with cancer. In 25 patients central venous catheters with subcutaneous ports and in 34 patients lines with external ending were inserted. Catheters were left in place respectively 62-836 days and 4-365 days. During that time 10 catheters were removed due to occlusion, leakage, local infection or sepsis. The causes of these complications were analyzed in discussion.

Adolescent↗
PubMed1998

[The case of neurofibromatosis type ! in a 5-year-old boy].

In the work we present the case of a 5-year-old boy who was admitted to the clinic because of the tumour in mediastinum. According to the results of the investigation the diagnosis of Recklinghausen disease was made. The tumour was situated in the region of pharynx, neck and mediastinum. The diagnosis was based on the characteristic features in the physical examination (café-au-laît spots, freckles in armpits and grains) and accessory investigations (x-ray, CT, NMR and histopathology). In the boy's family this disease was not noticed, although in his mother we observed café-au-laît spots on the skin of abdomen. Despite the fact that the diagnosed disease is known as a mild one (from the histopathological point of view) in the case of our patient it turned out to be much more clinically malignant because of the localization of the tumour. This situation forced us to the application of much more aggressive treatment (chemotherapy, operation).

Cafe-au-Lait Spots↗
PubMed1998

[Severe hypoglycemia in diabetic children and adolescents: frequency and circumstances of occurrence].

In 103 children and adolescents aged 13.6+/-5.5 years with type I diabetes lasting for 5.9+/-3.1 years, we have retrospectively studied the frequency and circumstances of severe hypoglycemic episodes (coma and/or convulsions). There were 71 severe hypoglycemia during the 5 year follow-up period. One third of patients had one or more severe hypoglycemia during the 5 years, therefore 6.4% of patients had at least one severe hypoglycemia every year. 8.7% of patients had 3 or more hypoglycemia within 5 years. Both glycated hemoglobin and insulin dose were comparable in patients with, or without severe hypoglycemia. Only in one third of the hypoglycemic episodes an apparent cause was found. We conclude that, most often, severe hypoglycemia occur in diabetic children without an identifiable cause and without any direct relationship with the level of glycated hemoglobin (HbA1c).

English Abstract↗
PubMed1998

[Effect of recombinant human growth hormone treatment on glucose metabolism].

Deciding to administer human growth hormone (hGH, somatotrophin) physicians often consider the possibility of adverse reactions of such a treatment, and among the others, they have regard to its effects on glucose metabolism. The problem is particularly important in patients treated with higher than physiological doses of hGH (children with constitutional short stature, girls with Turner's syndrome). Recent studies suggest, that although the effect of hGH on glucose metabolism is undeniable, replacement doses of this hormone practically do not threaten with diabetes development, but its higher than physiological doses can impair insulin secretion and, in exceptional cases, cause transient diabetes.

English Abstract↗
PubMed1998

CTLA-4 gene polymorphism is associated with predisposition to IDDM in a population from central Poland.

Susceptibility to insulin-dependent diabetes mellitus (IDDM) is strongly associated with particular HLA class II alleles. However, non-HLA genetic factors are likely to be required for the development of the disease. The candidate genes include the cytoxic T-lymphocyte associated-4 (CTLA-4) gene located on chromosome 2q33, which encodes a cell surface molecule providing a negative signal for T-cell activation. We investigated CTLA-4 exon 1 polymorphism (position 49 A/G) in 192 IDDM children and 136 healthy controls from Central Poland, using allele-specific hybridisation. The CTLA-4/G allele was found on 56.0% of chromosomes in IDDM patients as compared to 43.4% in controls (p = 0.002), mostly in homozygous form (31.2% in patients vs 15.4% in controls, p = 0.002). This difference was even more pronounced in non-DRB1*03/non-DRB1*04 IDDM patients (G/G genotype frequency: 35.0% of IDDM patients vs 12.3% of controls, p = 0.04). Our data indicate that CTLA-4 exon 1 position 49 A/G dimorphism was significantly associated with predisposition to IDDM in our Central Poland population, particularly in patients lacking the strongly predisposing DRB1 alleles.

Adolescent↗
PubMed1997

Arylamine N-acetyltransferase (NAT2) gene mutations in children with allergic diseases.

The overrepresentation of phenotypically slow acetylators among patients with atopic allergy has been reported in previous studies. The N-acetyltransferase coding gene has not yet been investigated in allergic diseases. This study was designed to determine the differences in the distribution of mutation frequency and genotypes that encode normal and defective activity of N-acetyltransferase in children with atopic allergies compared with healthy children. In 56 children with documented inhalational, food, or mixed allergies and in 100 healthy control children with no clinical or laboratory signs of allergy, the genotype coding for N-acetyltransferase was identified by means of the polymerase chain reaction followed by analysis of restriction fragment length polymorphism. Nucleotide transitions in the following positions were investigated: 481 C-->T, 590 G-->A, 803 A-->G, and 857 G-->A, which enabled the identification of six genotypes, including the wild-type (wt) allele, and 16 genotypes, including mutated alleles (homozygotic and herterozygotic). The statistical analysis showed significant differences in the distribution of the frequency of the occurrence of mutated alleles and genotypes between the two groups of children. In 51 children (91%) with allergy, genotypes that encode acetylation defect were found; genotypes that code for normal N-acetyltransferase were observed in only five allergic children (9%). In the control group the distribution of genotypes coding for normal and defective N-acetyltransferase activity is 38% and 62%, respectively. Thus study enabled the conclusion that the slow acetylation genotype is a genetic marker of predisposition to atopy.

Adolescent↗
PubMed1996

[Morphological, microstereological and immunohistoenzymological studies of the jejuni of infants with recurrent constructive bronchitis and chronic diarrhea due to cow's milk protein allergy].

Morphological, microstereological and immunohistoenzymatic technique were used to assess jejunal biopsy samples obtained from 17 infants suffering from chronic diarrhoea and bronchitis spastica (the study group), and 5 infants with chronic diarrhoea and weight deficiency (group G). In the first group, histopathological studies revealed a small degree of villous atrophy (II degree) in 12/17 of cases, and in 5/17, a moderate atrophy (III degree). The microstereological technique disclosed infiltration of the submucosa which was significantly more marked in the study group as compared with group G (p < 0.05). Positive immunohistoenzymatic reactions in mononuclear cells of the submucosa infiltration were observed in all cases, but was more distinct in the first group. The results of the study show jejunal biopsy to be helpful in confirming the allergic etiology of the disease in the study group.

Animals↗
PubMed1996

[Diagnostic value of immunoglobulin E in serum of infants with spastic bronchitis and cow milk protein allergy depending on the method of examination].

We examined 83 infants suffering from spastic bronchitis and cow milk protein allergy and analyzed the diagnostic value of two allergic tests (Mancini, FAST) commonly used for measuring total IgE (t-IgE) level in serum. The aim of the study was to establish the sensitivity of these two methods. Our statistical analysis proved FAST test to be more sensitive than Mancini one (p < 0.01).

Bronchial Spasm↗
PubMed1995

Functional studies of intestinal mast cells in children with food intolerance.

The aim of this study was to characterize some functional properties of intestine mast cells taken from children with food intolerance. The cells were obtained from tissue specimens by the use of the enzymatic method and the sensitivity of mast cells to anti-IgE, substance P (SP) and vasoactive intestinal peptide (VIP) was studied in vitro. We have noticed that (1) mast cells were sensitive to the action of anti-IgE, but there was no correlation with total IgE level, (2) although mast cells were challenged with SP and VIP histamine release was low.

Child↗