Three biologically active peptides, [9-beta-(1-naphthyl)alanine]-ACTH-(1-19), [9-Ni-formyltryptophanl-ACTH-1(1-19), and (8-lysine,9-phenylalaninel-ACTH-1(1-9), have been synthesized by the solid-phase method. All of the synthetic peptides showed diminished biological activity compared to ACTH-(1-19). It was also shown that the steroidogenic and lipolytic activities of ACTH-(1-19) were not inhibited by [8-lysine,.-phenylalanine]-ACTH-(1-19).

Adipose Tissue↗

PubMed1975

The synthesis and biological activity of (165, 182, 189-S-carbamidomethylcysteine)-human growth hormone-(140-191).

The peptide [165, 182, 189-S-carbamidomethylcysteine]-human growth hormone-(140-191) has been synthesized by the solid-phase method. The complement fixation, lactogenic and growth-promoting activities of the synthetic peptide were comparable to that of [165, 182, 189-S-carbamidomethylcysteine]-human growth hormone-(141-191) that was derived from the native hormone.

Amino Acid Sequence↗

PubMed1975

Observer error in histological assessment of marrow hypocellularity.

Observer error in the assessment of marrow hypocellularity was studied by examining histological sections from 37 mice having normal or reduced marrow cellularity and comparing the estimated cellularity with a previously measured value. For marrows or mild or moderately reduced cellularity the subjective estimate of cellularity was almost valueless both in terms of accuracy and reproducibility. Only severely hypocellular marrows, having a cellularity of less than 17% of normal, could be recognized as being abnormal with some degree of accuracy and reproducibility.

Animals↗

PubMed1975

The best way to beat high taxes.

Explore the source record for details and available documents.

Income Tax↗

PubMed1975

Ocular aspects of internal carotid stenosis.

Because extracranial atheromatous disease of the carotid arterial system is a common cause of 'stroke', ophthalmologists may be the first to see patients at risk who present with early signs of this condition. I. The history of previous observations of these signs and the anatomy and physiology of the structures involved are described. The physical and subjective signs and the significance of transient ischaemic attacks are discussed. Methods of diagnosis are reviewed with special reference to ophthalmodynamometry. II. A series of patients personally investigated and treated is analysed: (1)Endarterectomy was performed in seventy cases of internal carotid artery stenosis during a 15-year period (1959-73). (2) 36 cases from the years 1970-73 were studied in detail. (3) 50 per cent. of these presented with ocular symptoms, which were the only complaint in 22 per cent. (4) 95 per cent. of all patients with ocular symptoms experienced recurrent transient visual loss. (5) 61 per cent. of all patients with ocular symptoms showed significant fundus changes. (6) ODM enabled the haemodynamics of the carotid arterial systems to be evaluated in 79 per cent. of the patients studied. (7) The results of surgery suggest that patients who present with ocular symptoms have a better prognosis than those who present with neurological symptoms only.

Adult↗

PubMed1975