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Biomedical subjects

J Blahos

Publications and source records attributed to J Blahos.

At least 91 records · Page 5Linked to original sources
PubMed1978

Effects of low calcium and low phosphorus diets on the duodenal absorption of calcium in betamethasone-treated chicks.

The effect of oral administration of betamethasone (25 microgram kg-1 day-1) on the duodenal absorption of calcium has been studied in chicks using the ligated loop technique in vivo. The chicks were fed normal calcium, normal phosphorus (NCaNP), low calcium, normal phosphorus (LCaNP) or normal calcium, low phosphorus (NCaLP) diets. Daily oral administration of betamethasone for 2-3 weeks markedly reduced the absorption of calcium in chicks fed the NCaNP diet, but did not significantly affect the adaptation in absorption when the NCaLP or LCaNP diets were fed for the same period of time. In one group of chicks, betamethasone was administered daily for 10 days before the birds were transferred to the NCaLP or LCaNP diets. Adaptation was again unaffected by betamethasone treatment. Administration of betamethasone caused a marked retardation in growth-rate, hypercalcaemia and an increased percentage of ash in the tibiae.

Animals↗
PubMed1976

The effect of calcitonin on glucose metabolism.

The authors have studied the effect of calcitonin on glucose metabolism. Ten healthy volunteers were investigated. Calcitonin administered intramuscularly in one single dose inhibited the physiological decrease of blood glucose levels during the forenoon fast. Salmon calcitonin administered in an intravenous infusion in the dose of 0.15 U MRC/kg of body weight impaired the glucose tolerance test with the increase of blood glucose levels. The greatest difference was in the 120th minute after the administration of 100 gm of glucose. Calcitonin failed to produce any significant inhibition of immunoreactive insulin release following the glucose stimulus. However, further studies will be necessary to show whether this lack of the inhibitory beta cytotropic action of calcitonin was due to the low dose of calcitonin.

Adult↗
PubMed1976

Effect of calcitonin on fracture healing in rats.

The influence of calcitonin on the healing of a fracture of tibial diaphysis in young rats has been studied with the aid of 85Sr investigations. The animals were subdivided into four groups (with facture + calcitonin, with fracture and no calcitonin, without fracture but with calcitonin treatment and intact controls). During the experimental period up to the day 38, repeated applications of calcitonin and 85Sr along with measurements of different parameters followed. These parameters consisted of: total body weights, 85Sr contents in the fractured and opposite tibiae, total body radioactivity of 85Sr, the weights of dried bones dissected after the day 38, the weights of bone ashes and the specific activity of 85Sr in the ashes. Increased 85Sr-uptake was seen as a sign of increased mineralisation of the callus. Calcitonin suppressed the resorption of bone during the callus formation and enhanced the mineralisation of callus to some extent. The main influence of calcitonin was seen to reduce the whole-body metabolic response to a localized skeletal injury--the fracture. The possible importance of this finding for the clinical practice is discussed briefly.

Animals↗
PubMed1975

Calcitonin activity assessed by calcium tolerance test in patients with thyroid disorders.

The calcium tolerance test was performed in 34 healthy subjects and in 103 patients with simple goitre, thyrotoxicosis, hypothyroidism, subacute thyroiditis, medullary carcinoma and in patients after subtotal or total thyroidectomy and after radioiodine therapy. Calcium lowering activity which reflects mainly the activity of clacitonin, was significantly impaired in thyrotoxic and totally thyroidectomized patients. An abnormal calcium tolerance test in a patient with medullary carcinoma corresponded with large amounts of released calcitonin.

Calcitonin↗
PubMed1975

The role of age in the development of hypothyroidism after treatment with radoiodine.

The authors have studied the role of age in the development of posttherapeutic hypothyroidism in 141 patients treated with radioiodine for thyrotoxicosis. The minimum time of the follow up after treatment was 10 years. The patients were divided into two groups according to age at which the treatment was administered. The critical age was 55. The incidence of posttherapeutic hypothyroidism was significantly greater in the elderly patients. There was a gradual increase of incidence of posttherapeutic hypothyroidism during the 10 year follow up. The dangers of the thyroid treatment in the elderly hypothyroid patients with persisting cardiac involvement may be reduced by a concomitant administration of beta blocking agents.

Age Factors↗