Search PubMed⌕ Search

Biomedical subjects

J Black

Publications and source records attributed to J Black.

At least 307 records · Page 17Linked to original sources
PubMed1985

Lung abscesses in children: diagnostic and therapeutic needle aspiration.

Three children aged 17 months to 17 years developed right-sided peripheral lung abscesses. Clinical signs were fever and cough. Laboratory cultures were negative, and the patients did not respond to appropriate antibiotic coverage. Under fluoroscopic guidance, purulent material was removed from the abscesses by needle aspiration. The patients became afebrile within 24 hours; none suffered complications of bleeding or pneumothorax. Cultures of the aspirate were positive for microorganisms sensitive to the prescribed treatments. A simple aspiration technique is described and proposed as useful for selected patients when surgical drainage is recommended. There was no morbidity in our cases, and recovery from a typically prolonged course was shortened by the procedure.

Adolescent↗
PubMed1985

When do patients given intrathecal morphine need postoperative systemic opiates?

A prospective, randomised study has compared the requirements for intramuscular papaveretum after cholecystectomy in patients given either 0.8 mg intrathecal morphine preoperatively or intravenous papaveretum peroperatively. Patients given intrathecal morphine required significantly less papaveretum during the first 48 hours after operation, but no significant difference in analgesic requirements was observed by 72 hours due to a continuing demand for papaveretum by these patients.

Adult↗
PubMed1985

Electrical stimulation of hard and soft tissues in animal models.

Studies in animals have clearly established that various forms of electrical stimulation positively affect the growth, repair, and remodeling of hard and soft tissue. Although the various electrical stimulation modalities (faradic, capacitive, and inductive) are different in their physics and biochemistry, each produces a variety of biological responses in a wide range of animal models. The level of interest in animal studies of electrical stimulation is rising rapidly, and new understanding, in parallel with studies in vitro and in the clinic, will continue to be gained. The future holds the promise of a wide range of hard and soft tissue conditions being routinely treated by electrical stimulation, based in part on progress in studies in animals.

Animals↗
PubMed1984

Relaxation and contraction responses to histamine in the human lung parenchymal strip.

The action of histamine on the human lung parenchymal strip preparation was investigated. Histamine produced relaxation at low concentrations and contraction at higher concentrations. Mepyramine, an H1-receptor antagonist partially inhibited both relaxation and contraction responses. The H2-receptor antagonists, cimetidine and metiamide were without significant effect. Propranolol, disodium cromoglycate (DSCG) and atropine did not alter histamine responses. Indomethacin, in some experiments, potentiated the contractile responses to histamine.

Cimetidine↗
PubMed1984

Ruptured aortic aneurysms: postoperative complications and their aetiology.

A review of 198 ruptured aortic aneurysms has been undertaken, this being 36.3 per cent of all the aneurysms treated during the period 1960-81. The overall mortality rate was 42.9 per cent. The peroperative mortality was 6.6 per cent and the mortality of the patients who survived the operation was 38.9 per cent. Factors which influenced postoperative mortality were the age of the patient, the distance travelled to hospital, the presence of an intraperitoneal bleed, the duration of the operative procedure and the volume of blood transfused, but only the amount of blood transfused had a statistically significant influence on mortality. However, as the highest mortality associated with any of these risk factors was 54.9 per cent, no single factor alone can be considered a contra-indication to operation. As there are no reliable predictive factors, we believe that all cases with clinically ruptured aortic aneurysms should have a laparotomy and resection. The most common postoperative complications were varying degrees of renal and respiratory insufficiency and the occurrence of these was significantly associated with the volume of blood transfused.

Acute Kidney Injury↗
PubMed1984

Acute gastrointestinal complications of infrarenal aortic aneurysm repair.

Acute gastrointestinal complications developed in 31 of 472 patients following aortic aneurysmectomy (6.6 per cent). In order of frequency these were: ischaemic intestine in nine patients, mechanical or paralytic ileus in eight patients, peptic ulceration in seven patients, undiagnosed gastrointestinal bleeding in five patients and paraprosthetic fistula in two patients. The risk of developing peptic ulcer complications was not significantly increased in patients with a previous history of peptic ulcer disease. The risk of developing an ischaemic intestine was increased if the distal limb of a prosthesis was anastomosed directly to the external iliac artery. The associated mortality was high and 21 (67.7 per cent) patients died. 33.3 per cent of the mortality occurring with elective aneurysm resection was associated with gastrointestinal complications.

Acute Disease↗
PubMed1984

Isolation of serum protein organometallic corrosion products from 316LSS and HS-21 in vitro and in vivo.

An investigation into blood-borne organometallic compounds that arise from the corrosion of metals used in orthopedic prosthetic devices was conducted using an in vivo rat model with an implantation time of 10 days and an in vitro human serum model with an incubation time of 5 days. Both models involved 316LSS and HS-21 in the spherical powder form of 55 +/- 5 microns microns in diameter at three different surface areas to body weight ratios. Gel chromatography on cross-linked dextran (G-200) was used to fractionate the serum proteins which bound the metal ions (chromium, cobalt, and nickel) released and identify them. Atomic absorption-spectrophotometry analysis measured the concentration of the metal ions in each serum protein peak as well as whole serum from both models, and red cell and tissue from the in vivo model. Within the serum proteins, the metal ions were bound to two of the principal serum protein peaks. Similar distributions of the metals among the serum protein peaks were not noted.

Alloys↗
PubMed1984

Systemic effects of biomaterials.

Evaluation of the host response to implanted biomaterials usually focuses on the implant site tissue response. This may lead to erroneous conclusions in the same way that examination of battles outside of their historic context does. A broader view discloses a variety of possible and actual systemic effects of carcinogenic, metabolic, immunological and bacteriological nature. Recognition of these effects in patients is hampered by a lack of epidemiological studies.

Animals↗
PubMed1984

Alpha thalassaemia in pregnancy.

Alpha thalassaemia as a cause of hypochromic, microcytic anaemia in pregnancy is described. The problems associated with accurate diagnosis of this condition and prediction of fetal outcome is now made much easier by use of recombinant DNA techniques such as gene mapping. Two Greek Cypriot families with alpha thalassaemia have been studied by DNA mapping. Definitive assessment of alpha thalassaemia genotype in these cases enabled confident genetic counselling.

Adult↗
PubMed1984

Isoelectric focusing in agarose gel for detection and identification of hemoglobin variants.

The use of isoelectric focusing in agarose gel was examined to test its usefulness for screening of cord blood hemoglobins and for the identification of hemoglobin variants in general. Advantages of agarose include: short running times, ease of preparation, and nontoxicity. In cord blood samples identification of Hb S, Hb C, and Hb Bart's was achieved. Separation of 16 hemoglobin variants, including six of clinical and geographical importance, was shown.

Electrophoresis, Agar Gel↗